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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q22.2
Chromosome location (bp)
102347211 - 102378670
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q13490 [Direct mapping] Baculoviral IAP repeat-containing protein 2
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0001666[response to hypoxia] GO:0001741[XY body] GO:0001890[placenta development] GO:0003713[transcription coactivator activity] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007166[cell surface receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0008270[zinc ion binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0010243[response to organonitrogen compound] GO:0014070[response to organic cyclic compound] GO:0016740[transferase activity] GO:0031398[positive regulation of protein ubiquitination] GO:0032991[protein-containing complex] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034121[regulation of toll-like receptor signaling pathway] GO:0035631[CD40 receptor complex] GO:0038061[NIK/NF-kappaB signaling] GO:0039535[regulation of RIG-I signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130[ubiquitin binding] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0044877[protein-containing complex binding] GO:0045088[regulation of innate immune response] GO:0045121[membrane raft] GO:0045471[response to ethanol] GO:0045595[regulation of cell differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0047485[protein N-terminus binding] GO:0050727[regulation of inflammatory response] GO:0051087[chaperone binding] GO:0051591[response to cAMP] GO:0051726[regulation of cell cycle] GO:0052548[regulation of endopeptidase activity] GO:0060544[regulation of necroptotic process] GO:0060546[negative regulation of necroptotic process] GO:0061630[ubiquitin protein ligase activity] GO:0070266[necroptotic process] GO:0070424[regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:0071356[cellular response to tumor necrosis factor] GO:0098770[FBXO family protein binding] GO:1901222[regulation of NIK/NF-kappaB signaling] GO:1902443[negative regulation of ripoptosome assembly involved in necroptotic process] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1902524[positive regulation of protein K48-linked ubiquitination] GO:1902527[positive regulation of protein monoubiquitination] GO:1902916[positive regulation of protein polyubiquitination] GO:2000116[regulation of cysteine-type endopeptidase activity] GO:2000377[regulation of reactive oxygen species metabolic process]
Q13490 [Direct mapping] Baculoviral IAP repeat-containing protein 2
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0003713[transcription coactivator activity] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007166[cell surface receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0008270[zinc ion binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0016740[transferase activity] GO:0031398[positive regulation of protein ubiquitination] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034121[regulation of toll-like receptor signaling pathway] GO:0035631[CD40 receptor complex] GO:0038061[NIK/NF-kappaB signaling] GO:0039535[regulation of RIG-I signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130[ubiquitin binding] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045088[regulation of innate immune response] GO:0045595[regulation of cell differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0047485[protein N-terminus binding] GO:0050727[regulation of inflammatory response] GO:0051087[chaperone binding] GO:0051726[regulation of cell cycle] GO:0052548[regulation of endopeptidase activity] GO:0060544[regulation of necroptotic process] GO:0060546[negative regulation of necroptotic process] GO:0061630[ubiquitin protein ligase activity] GO:0070424[regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:0098770[FBXO family protein binding] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1902524[positive regulation of protein K48-linked ubiquitination] GO:1902527[positive regulation of protein monoubiquitination] GO:2000116[regulation of cysteine-type endopeptidase activity]
E9PI77 [Direct mapping] Baculoviral IAP repeat-containing protein 2
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0042981[regulation of apoptotic process] GO:0043067[regulation of programmed cell death] GO:0046872[metal ion binding]
Q13490 [Direct mapping] Baculoviral IAP repeat-containing protein 2
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209[protein polyubiquitination] GO:0003713[transcription coactivator activity] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0007166[cell surface receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0008270[zinc ion binding] GO:0009898[cytoplasmic side of plasma membrane] GO:0016740[transferase activity] GO:0031398[positive regulation of protein ubiquitination] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0034121[regulation of toll-like receptor signaling pathway] GO:0035631[CD40 receptor complex] GO:0038061[NIK/NF-kappaB signaling] GO:0039535[regulation of RIG-I signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130[ubiquitin binding] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045088[regulation of innate immune response] GO:0045595[regulation of cell differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0047485[protein N-terminus binding] GO:0050727[regulation of inflammatory response] GO:0051087[chaperone binding] GO:0051726[regulation of cell cycle] GO:0052548[regulation of endopeptidase activity] GO:0060544[regulation of necroptotic process] GO:0060546[negative regulation of necroptotic process] GO:0061630[ubiquitin protein ligase activity] GO:0070424[regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:0098770[FBXO family protein binding] GO:1902523[positive regulation of protein K63-linked ubiquitination] GO:1902524[positive regulation of protein K48-linked ubiquitination] GO:1902527[positive regulation of protein monoubiquitination] GO:2000116[regulation of cysteine-type endopeptidase activity]
The Human Protein Atlas project is funded
