GENERAL INFORMATIONi
Gene namei MDK
Synonyms FLJ27379, MK, NEGF2
Gene descriptioni Midkine
Protein classi Cancer-related genes
Predicted locationi Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 11
Cytoband p11.2
Chromosome location (bp) 46380756 - 46383837
Number of transcriptsi 8
Ensembl ENSG00000110492 (version 109)
Entrez gene 4192
HGNC HGNC:6972
UniProt P21741 (UniProt - Evidence at protein level)
neXtProt NX_P21741
GeneCards MDK
Antibodypedia MDK antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors 1, 2, 3, 4, 5, 6, 7, 8. Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups 9, 10. Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration 11, 12, 13, 14, 15, 16, 17, 18, 19. Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression 20, 21. This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively 22. Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation 23. Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival 24. Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion 25, 26. Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 27. Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth 28, 29. Binds LRP1; promotes neuronal survival 30. Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation 31. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation 32. Promotes epithelial to mesenchymal transition through interaction with NOTCH2 33. During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity). show less
Molecular function (UniProt)i Developmental protein, Growth factor, Heparin-binding, Mitogen
Biological process (UniProt)i Differentiation
Gene summary (Entrez)i This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
MDK-201
ENSP00000352852
ENST00000359803
P21741
[Direct mapping] Midkine
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002232 [leukocyte chemotaxis involved in inflammatory response]
GO:0002286 [T cell activation involved in immune response]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007010 [cytoskeleton organization]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0009611 [response to wounding]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0010976 [positive regulation of neuron projection development]
GO:0010996 [response to auditory stimulus]
GO:0030154 [cell differentiation]
GO:0030279 [negative regulation of ossification]
GO:0030325 [adrenal gland development]
GO:0030335 [positive regulation of cell migration]
GO:0032330 [regulation of chondrocyte differentiation]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0035374 [chondroitin sulfate binding]
GO:0042246 [tissue regeneration]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044849 [estrous cycle]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045590 [negative regulation of regulatory T cell differentiation]
GO:0045785 [positive regulation of cell adhesion]
GO:0046850 [regulation of bone remodeling]
GO:0048477 [oogenesis]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050896 [response to stimulus]
GO:0051781 [positive regulation of cell division]
GO:0061036 [positive regulation of cartilage development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0071673 [positive regulation of smooth muscle cell chemotaxis]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0106015 [negative regulation of inflammatory response to wounding]
GO:0106016 [positive regulation of inflammatory response to wounding]
GO:0106091 [glial cell projection elongation]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903039 [positive regulation of leukocyte cell-cell adhesion]
GO:1904036 [negative regulation of epithelial cell apoptotic process]
GO:1904399 [heparan sulfate binding]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:1905555 [positive regulation of blood vessel branching]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:1905653 [positive regulation of artery morphogenesis]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2001224 [positive regulation of neuron migration]
Show all
 143 aa
15.6 kDa 		Yes 0
MDK-202
ENSP00000378932
ENST00000395565
P21741
[Direct mapping] Midkine
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002232 [leukocyte chemotaxis involved in inflammatory response]
GO:0002286 [T cell activation involved in immune response]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007010 [cytoskeleton organization]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0009611 [response to wounding]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0010976 [positive regulation of neuron projection development]
GO:0010996 [response to auditory stimulus]
GO:0030154 [cell differentiation]
GO:0030279 [negative regulation of ossification]
GO:0030325 [adrenal gland development]
GO:0030335 [positive regulation of cell migration]
GO:0032330 [regulation of chondrocyte differentiation]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0035374 [chondroitin sulfate binding]
GO:0042246 [tissue regeneration]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044849 [estrous cycle]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045590 [negative regulation of regulatory T cell differentiation]
GO:0045785 [positive regulation of cell adhesion]
GO:0046850 [regulation of bone remodeling]
GO:0048477 [oogenesis]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050896 [response to stimulus]
GO:0051781 [positive regulation of cell division]
GO:0061036 [positive regulation of cartilage development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0071673 [positive regulation of smooth muscle cell chemotaxis]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0106015 [negative regulation of inflammatory response to wounding]
GO:0106016 [positive regulation of inflammatory response to wounding]
GO:0106091 [glial cell projection elongation]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903039 [positive regulation of leukocyte cell-cell adhesion]
GO:1904036 [negative regulation of epithelial cell apoptotic process]
GO:1904399 [heparan sulfate binding]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:1905555 [positive regulation of blood vessel branching]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:1905653 [positive regulation of artery morphogenesis]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2001224 [positive regulation of neuron migration]
Show all
 143 aa
15.6 kDa 		Yes 0
MDK-203
ENSP00000378933
ENST00000395566
P21741
[Direct mapping] Midkine
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001662 [behavioral fear response]
GO:0002232 [leukocyte chemotaxis involved in inflammatory response]
GO:0002286 [T cell activation involved in immune response]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0007010 [cytoskeleton organization]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007614 [short-term memory]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0009410 [response to xenobiotic stimulus]
GO:0009611 [response to wounding]
GO:0009725 [response to hormone]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0010976 [positive regulation of neuron projection development]
GO:0010996 [response to auditory stimulus]
GO:0016477 [cell migration]
GO:0021542 [dentate gyrus development]
GO:0021681 [cerebellar granular layer development]
GO:0021766 [hippocampus development]
GO:0021987 [cerebral cortex development]
GO:0030154 [cell differentiation]
GO:0030279 [negative regulation of ossification]
GO:0030325 [adrenal gland development]
GO:0030335 [positive regulation of cell migration]
GO:0030421 [defecation]
GO:0032330 [regulation of chondrocyte differentiation]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0035374 [chondroitin sulfate binding]
GO:0042246 [tissue regeneration]
GO:0042995 [cell projection]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044849 [estrous cycle]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045590 [negative regulation of regulatory T cell differentiation]
GO:0045785 [positive regulation of cell adhesion]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046850 [regulation of bone remodeling]
GO:0048477 [oogenesis]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050795 [regulation of behavior]
GO:0050896 [response to stimulus]
GO:0051384 [response to glucocorticoid]
GO:0051781 [positive regulation of cell division]
GO:0061036 [positive regulation of cartilage development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0071673 [positive regulation of smooth muscle cell chemotaxis]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0106015 [negative regulation of inflammatory response to wounding]
GO:0106016 [positive regulation of inflammatory response to wounding]
GO:0106091 [glial cell projection elongation]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1901215 [negative regulation of neuron death]
GO:1903039 [positive regulation of leukocyte cell-cell adhesion]
GO:1904036 [negative regulation of epithelial cell apoptotic process]
GO:1904399 [heparan sulfate binding]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:1905555 [positive regulation of blood vessel branching]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:1905653 [positive regulation of artery morphogenesis]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2001224 [positive regulation of neuron migration]
Show all
 143 aa
15.6 kDa 		Yes 0
MDK-204
ENSP00000378936
ENST00000395569
P21741
[Direct mapping] Midkine
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002232 [leukocyte chemotaxis involved in inflammatory response]
GO:0002286 [T cell activation involved in immune response]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007010 [cytoskeleton organization]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0009611 [response to wounding]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0010976 [positive regulation of neuron projection development]
GO:0010996 [response to auditory stimulus]
GO:0030154 [cell differentiation]
GO:0030279 [negative regulation of ossification]
GO:0030325 [adrenal gland development]
GO:0030335 [positive regulation of cell migration]
GO:0032330 [regulation of chondrocyte differentiation]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0035374 [chondroitin sulfate binding]
GO:0042246 [tissue regeneration]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044849 [estrous cycle]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045590 [negative regulation of regulatory T cell differentiation]
GO:0045785 [positive regulation of cell adhesion]
GO:0046850 [regulation of bone remodeling]
GO:0048477 [oogenesis]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050896 [response to stimulus]
GO:0051781 [positive regulation of cell division]
GO:0061036 [positive regulation of cartilage development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0071673 [positive regulation of smooth muscle cell chemotaxis]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0106015 [negative regulation of inflammatory response to wounding]
GO:0106016 [positive regulation of inflammatory response to wounding]
GO:0106091 [glial cell projection elongation]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903039 [positive regulation of leukocyte cell-cell adhesion]
GO:1904036 [negative regulation of epithelial cell apoptotic process]
GO:1904399 [heparan sulfate binding]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:1905555 [positive regulation of blood vessel branching]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:1905653 [positive regulation of artery morphogenesis]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2001224 [positive regulation of neuron migration]
Show all
 87 aa
9.5 kDa 		Yes 0
MDK-205
ENSP00000385451
ENST00000405308
P21741
[Direct mapping] Midkine
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002232 [leukocyte chemotaxis involved in inflammatory response]
GO:0002286 [T cell activation involved in immune response]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007010 [cytoskeleton organization]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0009611 [response to wounding]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0010976 [positive regulation of neuron projection development]
GO:0010996 [response to auditory stimulus]
GO:0030154 [cell differentiation]
GO:0030279 [negative regulation of ossification]
GO:0030325 [adrenal gland development]
GO:0030335 [positive regulation of cell migration]
GO:0032330 [regulation of chondrocyte differentiation]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0035374 [chondroitin sulfate binding]
GO:0042246 [tissue regeneration]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044849 [estrous cycle]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045590 [negative regulation of regulatory T cell differentiation]
GO:0045785 [positive regulation of cell adhesion]
GO:0046850 [regulation of bone remodeling]
GO:0048477 [oogenesis]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050896 [response to stimulus]
GO:0051781 [positive regulation of cell division]
GO:0061036 [positive regulation of cartilage development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0071673 [positive regulation of smooth muscle cell chemotaxis]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0106015 [negative regulation of inflammatory response to wounding]
GO:0106016 [positive regulation of inflammatory response to wounding]
GO:0106091 [glial cell projection elongation]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903039 [positive regulation of leukocyte cell-cell adhesion]
GO:1904036 [negative regulation of epithelial cell apoptotic process]
GO:1904399 [heparan sulfate binding]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:1905555 [positive regulation of blood vessel branching]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:1905653 [positive regulation of artery morphogenesis]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2001224 [positive regulation of neuron migration]
Show all
 143 aa
15.6 kDa 		Yes 0
MDK-206
ENSP00000384034
ENST00000407067
P21741
[Direct mapping] Midkine
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002232 [leukocyte chemotaxis involved in inflammatory response]
GO:0002286 [T cell activation involved in immune response]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007010 [cytoskeleton organization]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0009611 [response to wounding]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0010976 [positive regulation of neuron projection development]
GO:0010996 [response to auditory stimulus]
GO:0030154 [cell differentiation]
GO:0030279 [negative regulation of ossification]
GO:0030325 [adrenal gland development]
GO:0030335 [positive regulation of cell migration]
GO:0032330 [regulation of chondrocyte differentiation]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0035374 [chondroitin sulfate binding]
GO:0042246 [tissue regeneration]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044849 [estrous cycle]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045590 [negative regulation of regulatory T cell differentiation]
GO:0045785 [positive regulation of cell adhesion]
GO:0046850 [regulation of bone remodeling]
GO:0048477 [oogenesis]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050896 [response to stimulus]
GO:0051781 [positive regulation of cell division]
GO:0061036 [positive regulation of cartilage development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0071673 [positive regulation of smooth muscle cell chemotaxis]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0106015 [negative regulation of inflammatory response to wounding]
GO:0106016 [positive regulation of inflammatory response to wounding]
GO:0106091 [glial cell projection elongation]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1903039 [positive regulation of leukocyte cell-cell adhesion]
GO:1904036 [negative regulation of epithelial cell apoptotic process]
GO:1904399 [heparan sulfate binding]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:1905555 [positive regulation of blood vessel branching]
GO:1905564 [positive regulation of vascular endothelial cell proliferation]
GO:1905653 [positive regulation of artery morphogenesis]
GO:2000179 [positive regulation of neural precursor cell proliferation]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000391 [positive regulation of neutrophil extravasation]
GO:2001224 [positive regulation of neuron migration]
Show all
 143 aa
15.6 kDa 		Yes 0
MDK-207
ENSP00000416241
ENST00000441869
C9JHA4
[Direct mapping] Midkine
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
Show all
 49 aa
5.2 kDa 		Yes 0
MDK-212
ENSP00000432649
ENST00000533952
E9PPJ5
[Direct mapping] Midkine
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0050896 [response to stimulus]
GO:0051781 [positive regulation of cell division]
Show all
 131 aa
14.4 kDa 		Yes 0

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