Brain tissue expression of CAMKK2 - Mouse brain

MOUSE BRAIN TISSUE

Gene description	Calcium/calmodulin dependent protein kinase kinase 2
Mouse gene	ENSMUSG00000029471 (version 10)
Annotation summary	CAMKK2 RNA is quite widespread across various human organs but is highly enriched in the CNS. In the mouse, both RNA and protein are highly expressed throughout the brain, with the protein localised in neuronal nuclei, cytoplasm and neurites, exhibiting lower levels in midbrain and medulla, compared to telencephalic and diencephalic regions.
Positive cells and structuresⁱ Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain.	Soma, nucleus, dendrite, axon and synapse in neurons.

FRONT BACK

Olfactory bulb

Midbrain

Pons/medulla

Hippocampal formation

	Protein
	Relative fluorescence intensityⁱ Protein expression in mouse brain using immunofluorescence is reported as mean fluorescence intensity .
Mouse brain region	255 0
Cerebral cortex
Frontal association cortex (fra)
Motor cortex (m)
Cingulate cortex (cg)
Piriform cortex, L1 (pirl1)
Piriform cortex, L2 (pirl2)
Piriform cortex, L3 (pirl3)
Insular cortex (i)
Somatosensory cortex (s)
Retrosplenial granular cortex (rsg)
Parietal association cortex (p)
Entorhinal cortex (ent)
Visual cortex (v)
Olfactory bulb
Anterior olfactory nucleus (aon)
Granule cell layer (gro)
Internal plexiform layer (ipl)
Mitral cell layer (mi)
Glomerular layer (gl)
Rostral migratory stream (rms)
External plexiform layer (epl)
External plexiform layer of the accessory OB (epla)
Granule cell layer of the accessory OB (gra)
Glomerular layer of the accessory OB (gla)
Hippocampus
Polymorph layer of the dentate gyrus (podg)
Molecular layer of the dentate gyrus (modg)
Granular dentate gyrus (grdg)
CA1 - oriens layer (ca1or)
CA1 - pyramidal layer (ca1py)
CA1 - radiatum layer (ca1ra)
CA2 - oriens layer (ca2or)
CA2 - pyramidal layer (ca2py)
CA2 - radiatum layer (ca2ra)
CA3 - oriens layer (ca3or)
CA3 - pyramidal layer (ca3py)
CA3 - radiatum layer (ca3ra)
Stratum lucidum (slu)
Lacunosum moleculare (lmol)
Subiculum (sub)
Amygdala
Nucleus of the lateral olfactory tract (lot)
Basal medial amygdaloid nucleus (bma)
Basal lateral amygdala* (*bla)	N/A
Basal lateral amygdaloid nucleus (bla)
Cortical amygdala (aco)
Central amygdala (ce)
Medial amygdaloid nucleus (mea)
Thalamus
Medial geniculate nucleus (mg)
Parafascicular thalamic nucleus (pf)
Pregeniculate nucleus (pg)
Stria terminalis (st)
Zona incerta (zi)
Anterodorsal thalamic nucleus (ad)
Reticular thalamic nucleus (rt)
Vental anterior thalamic nucleus (va)	N/A
Medial habenular nucleus (mhb)
Laterodorsal thalamic area (ld)
Paraventricular thalamic nucleus (pv)
Central medial thalamic area (cm)
Ventral lateral thalamic area (vl)	N/A
Ventral medial thalamic area (vm)
Lateral habenulal nucleus (lhb)
Ventral posterior thalamus (vpt)
Anterior pretactal nucleus (apt)
Retromammillary nucleus (rm)
Hypothalamus
Dorsal tuberomammillary nucleus (dtm)
Mammillary nucleus (mn)
Periventricular hypothalamic nucleus (pe)
Supraoptic nucleus (so)
Tuberal nucleus (tu)
Ventral tuberomammillary nucleus (vtm)
Lateral preoptic area (lpo)
Medial preoptic area (mpo)
Suprachiasmatic nucleus (sch)
Paraventricular hypothalamic nucleus (pa)
Anterior hypothalamic area, central (ahc)
Ventral medial hypothalamic nucleus (vmh)
Ventral medial hypothalamic nucleus* (*vmh)	N/A
Arcuate nucleus (arc)
Arcuate nucleus* (*arc)	N/A
Peduncular part of lateral hypothalmus (plh)
Dorsal medial hypothalamic nucleus (dm)
Stria terminalis* (*st)	N/A
Cerebellum
Vestibulocerebellar nucleus (vecb)	N/A
Moleuclar layer of the cerebellum (cemol)
Purkinje layer of the cerebellum (cepur)
Granular layer of the cerebellum (cegr)
Pons
Barrington's nucleus (bar)	N/A
Koelliker-fuse nucleus (kf)	N/A
Motor tregiminal nucleus (5n)
Parabrachial nucleus (pbp)
Principle sensory trigeminal nucleus (pr5)
Locus coeruleus (lc)
Pontine nucleus (pn)
Vestibular nucleus (ve)
Pontine reticular nucleus, oral (pno)
Lateral lemniscus (ll)
Superior paraolivary nucleus (spo)
Circumventricular organs
Subcommissural organ (sco)
Subfornical organ (sfo)
Median eminence (me)
Medulla (ap)	N/A

Antibodies in assayⁱ The internal antibody ID for the antibody/antibodies available for this specific target, click link for more antibody information.
HPA063713