GENERAL INFORMATIONi
Gene namei PTPN6
Synonyms HCP, HCPH, PTP-1C, SHP-1, SHP1
Gene descriptioni Protein tyrosine phosphatase non-receptor type 6
Protein classi Enzymes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 12
Cytoband p13.31
Chromosome location (bp) 6946468 - 6961316
Number of transcriptsi 7
Ensembl ENSG00000111679 (version 109)
Entrez gene 5777
HGNC HGNC:9658
UniProt P29350 (UniProt - Evidence at protein level)
neXtProt NX_P29350
GeneCards PTPN6
Antibodypedia PTPN6 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. show less
Molecular function (UniProt)i Hydrolase, Protein phosphatase
Gene summary (Entrez)i The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PTPN6-201
ENSP00000326010
ENST00000318974
P29350
[Direct mapping] Tyrosine-protein phosphatase non-receptor type 6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000278 [mitotic cell cycle]
GO:0001784 [phosphotyrosine residue binding]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0002924 [negative regulation of humoral immune response mediated by circulating immunoglobulin]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0006470 [protein dephosphorylation]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0017124 [SH3 domain binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030220 [platelet formation]
GO:0031295 [T cell costimulation]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032991 [protein-containing complex]
GO:0033007 [negative regulation of mast cell activation involved in immune response]
GO:0033277 [abortive mitotic cell cycle]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035580 [specific granule lumen]
GO:0035855 [megakaryocyte development]
GO:0042098 [T cell proliferation]
GO:0042105 [alpha-beta T cell receptor complex]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0042267 [natural killer cell mediated cytotoxicity]
GO:0042981 [regulation of apoptotic process]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043409 [negative regulation of MAPK cascade]
GO:0045577 [regulation of B cell differentiation]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050839 [cell adhesion molecule binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071310 [cellular response to organic substance]
GO:0140031 [phosphorylation-dependent protein binding]
GO:1904724 [tertiary granule lumen]
GO:1905867 [epididymis development]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
Show all
 595 aa
67.6 kDa 		No 0
PTPN6-202
ENSP00000382376
ENST00000399448
P29350
[Direct mapping] Tyrosine-protein phosphatase non-receptor type 6
Show all
Q53XS4
[Target identity:100%; Query identity:100%] Tyrosine-protein phosphatase non-receptor type
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0001784 [phosphotyrosine residue binding]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0031295 [T cell costimulation]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032991 [protein-containing complex]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035580 [specific granule lumen]
GO:0042981 [regulation of apoptotic process]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071310 [cellular response to organic substance]
GO:0140031 [phosphorylation-dependent protein binding]
GO:1904724 [tertiary granule lumen]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
Show all
 597 aa
67.7 kDa 		No 0
PTPN6-204
ENSP00000391592
ENST00000456013
P29350
[Direct mapping] Tyrosine-protein phosphatase non-receptor type 6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0001784 [phosphotyrosine residue binding]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0016791 [phosphatase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0031295 [T cell costimulation]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032991 [protein-containing complex]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035580 [specific granule lumen]
GO:0042981 [regulation of apoptotic process]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071310 [cellular response to organic substance]
GO:0140031 [phosphorylation-dependent protein binding]
GO:1904724 [tertiary granule lumen]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
Show all
 624 aa
70.1 kDa 		No 0
PTPN6-211
ENSP00000438740
ENST00000538715
F5H0N8
[Direct mapping] Tyrosine-protein phosphatase non-receptor type 6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 165 aa
18.5 kDa 		No 0
PTPN6-215
ENSP00000445646
ENST00000541698
F5H1Z8
[Direct mapping] Tyrosine-protein phosphatase non-receptor type 6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 150 aa
17 kDa 		No 0
PTPN6-217
ENSP00000440114
ENST00000542462
F5GY79
[Direct mapping] Tyrosine-protein phosphatase non-receptor type 6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
16.1 kDa 		No 0
PTPN6-220
ENSP00000443393
ENST00000543115
F5H5H9
[Direct mapping] Tyrosine-protein phosphatase non-receptor type 6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
 130 aa
14.6 kDa 		No 0

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