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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
CD markers
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
p13.31
Chromosome location (bp)
8123617 - 8138607
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner 1. Involved in regulating immune reactivity 2,3. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 4,5. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production 6. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation 7....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Lectin, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9UMR7 [Direct mapping] C-type lectin domain family 4 member A
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CD markers Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0001818[negative regulation of cytokine production] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002470[plasmacytoid dendritic cell antigen processing and presentation] GO:0004888[transmembrane signaling receptor activity] GO:0005509[calcium ion binding] GO:0005537[mannose binding] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0007155[cell adhesion] GO:0007166[cell surface receptor signaling pathway] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0030246[carbohydrate binding] GO:0032720[negative regulation of tumor necrosis factor production] GO:0036037[CD8-positive, alpha-beta T cell activation] GO:0042590[antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0045087[innate immune response] GO:0046872[metal ion binding] GO:0061760[antifungal innate immune response]
Q9UMR7 [Direct mapping] C-type lectin domain family 4 member A
Show all
CD markers Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0001818[negative regulation of cytokine production] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002470[plasmacytoid dendritic cell antigen processing and presentation] GO:0004888[transmembrane signaling receptor activity] GO:0005509[calcium ion binding] GO:0005537[mannose binding] GO:0005886[plasma membrane] GO:0006955[immune response] GO:0007155[cell adhesion] GO:0007166[cell surface receptor signaling pathway] GO:0009897[external side of plasma membrane] GO:0016020[membrane] GO:0030246[carbohydrate binding] GO:0032720[negative regulation of tumor necrosis factor production] GO:0036037[CD8-positive, alpha-beta T cell activation] GO:0042590[antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0045087[innate immune response] GO:0046872[metal ion binding] GO:0061760[antifungal innate immune response]
The Human Protein Atlas project is funded
