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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p22.3
Chromosome location (bp)
24774931 - 24786099
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) 1,2,3,4. It is degraded during the mitotic phase of the cell cycle 5,6,7. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle 8,9,10. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing 11. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control 12....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA replication inhibitor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003682[chromatin binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006275[regulation of DNA replication] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008156[negative regulation of DNA replication] GO:0009887[animal organ morphogenesis] GO:0017053[transcription repressor complex] GO:0030174[regulation of DNA-templated DNA replication initiation] GO:0035563[positive regulation of chromatin binding] GO:0042826[histone deacetylase binding] GO:0045786[negative regulation of cell cycle] GO:0045892[negative regulation of DNA-templated transcription] GO:0065003[protein-containing complex assembly] GO:0071163[DNA replication preinitiation complex assembly] GO:0140297[DNA-binding transcription factor binding] GO:0140678[molecular function inhibitor activity] GO:2000104[negative regulation of DNA-templated DNA replication]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003682[chromatin binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006275[regulation of DNA replication] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008156[negative regulation of DNA replication] GO:0017053[transcription repressor complex] GO:0030174[regulation of DNA-templated DNA replication initiation] GO:0035563[positive regulation of chromatin binding] GO:0042826[histone deacetylase binding] GO:0045786[negative regulation of cell cycle] GO:0045892[negative regulation of DNA-templated transcription] GO:0071163[DNA replication preinitiation complex assembly] GO:0140678[molecular function inhibitor activity] GO:2000104[negative regulation of DNA-templated DNA replication]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682[chromatin binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006275[regulation of DNA replication] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008156[negative regulation of DNA replication] GO:0017053[transcription repressor complex] GO:0030174[regulation of DNA-templated DNA replication initiation] GO:0035563[positive regulation of chromatin binding] GO:0042826[histone deacetylase binding] GO:0045786[negative regulation of cell cycle] GO:0045892[negative regulation of DNA-templated transcription] GO:0071163[DNA replication preinitiation complex assembly] GO:0140678[molecular function inhibitor activity] GO:2000104[negative regulation of DNA-templated DNA replication]
The Human Protein Atlas project is funded
