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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q27
Chromosome location (bp)
168441151 - 168673445
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9H3U7 [Direct mapping] SPARC-related modular calcium-binding protein 2
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Human disease related genes Digestive system diseases Mouth and dental diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005604[basement membrane] GO:0005615[extracellular space] GO:0008201[heparin binding] GO:0010595[positive regulation of endothelial cell migration] GO:0030198[extracellular matrix organization] GO:0035470[positive regulation of vascular wound healing] GO:0045743[positive regulation of fibroblast growth factor receptor signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045931[positive regulation of mitotic cell cycle] GO:0046872[metal ion binding] GO:0050840[extracellular matrix binding] GO:0062023[collagen-containing extracellular matrix] GO:0071944[cell periphery] GO:1900748[positive regulation of vascular endothelial growth factor signaling pathway] GO:2000573[positive regulation of DNA biosynthetic process] GO:2001028[positive regulation of endothelial cell chemotaxis]
Q9H3U7 [Direct mapping] SPARC-related modular calcium-binding protein 2
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Human disease related genes Digestive system diseases Mouth and dental diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005604[basement membrane] GO:0005615[extracellular space] GO:0008201[heparin binding] GO:0010595[positive regulation of endothelial cell migration] GO:0030198[extracellular matrix organization] GO:0035470[positive regulation of vascular wound healing] GO:0045743[positive regulation of fibroblast growth factor receptor signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045931[positive regulation of mitotic cell cycle] GO:0046872[metal ion binding] GO:0050840[extracellular matrix binding] GO:0062023[collagen-containing extracellular matrix] GO:0071944[cell periphery] GO:1900748[positive regulation of vascular endothelial growth factor signaling pathway] GO:2000573[positive regulation of DNA biosynthetic process] GO:2001028[positive regulation of endothelial cell chemotaxis]
H0Y5I1 [Direct mapping] SPARC-related modular calcium-binding protein 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Digestive system diseases Mouth and dental diseases Protein evidence (Ezkurdia et al 2014)
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