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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q27
Chromosome location (bp)
170554302 - 170572870
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription 1. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) 2,3,4,5,6. The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 7,8. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C 9. TBP forms the TFIID-A module together with TAF3 and TAF5 10. TBP is a general transcription factor that functions at the core of the TFIID complex 11,12,13,14,15,16. During assembly of the core PIC on the promoter, as part of TFIID, TBP binds to and also bends promoter DNA, irrespective of whether the promoter contains a TATA box 17. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III 18. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC during RNA polymerase I-dependent transcription 19. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter 20. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA 21....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Sheet binding to DNA Disease related genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0001046[core promoter sequence-specific DNA binding] GO:0001091[RNA polymerase II general transcription initiation factor binding] GO:0001093[TFIIB-class transcription factor binding] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005669[transcription factor TFIID complex] GO:0005672[transcription factor TFIIA complex] GO:0006352[DNA-templated transcription initiation] GO:0006366[transcription by RNA polymerase II] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006383[transcription by RNA polymerase III] GO:0006468[protein phosphorylation] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0017162[aryl hydrocarbon receptor binding] GO:0019899[enzyme binding] GO:0032991[protein-containing complex] GO:0042789[mRNA transcription by RNA polymerase II] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0097550[transcription preinitiation complex] GO:0140223[general transcription initiation factor activity] GO:0140297[DNA-binding transcription factor binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Sheet binding to DNA Disease related genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0001046[core promoter sequence-specific DNA binding] GO:0001091[RNA polymerase II general transcription initiation factor binding] GO:0001093[TFIIB-class transcription factor binding] GO:0001673[male germ cell nucleus] GO:0001674[female germ cell nucleus] GO:0001939[female pronucleus] GO:0001940[male pronucleus] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005668[RNA polymerase transcription factor SL1 complex] GO:0005669[transcription factor TFIID complex] GO:0005672[transcription factor TFIIA complex] GO:0005737[cytoplasm] GO:0006352[DNA-templated transcription initiation] GO:0006366[transcription by RNA polymerase II] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006383[transcription by RNA polymerase III] GO:0006468[protein phosphorylation] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0017162[aryl hydrocarbon receptor binding] GO:0019899[enzyme binding] GO:0032991[protein-containing complex] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045120[pronucleus] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0097550[transcription preinitiation complex] GO:0140223[general transcription initiation factor activity] GO:0140297[DNA-binding transcription factor binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors beta-Sheet binding to DNA Disease related genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000995[RNA polymerase III general transcription initiation factor activity] GO:0001046[core promoter sequence-specific DNA binding] GO:0001091[RNA polymerase II general transcription initiation factor binding] GO:0001093[TFIIB-class transcription factor binding] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005669[transcription factor TFIID complex] GO:0005672[transcription factor TFIIA complex] GO:0006352[DNA-templated transcription initiation] GO:0006366[transcription by RNA polymerase II] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006383[transcription by RNA polymerase III] GO:0006468[protein phosphorylation] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0017162[aryl hydrocarbon receptor binding] GO:0019899[enzyme binding] GO:0032991[protein-containing complex] GO:0042789[mRNA transcription by RNA polymerase II] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0097550[transcription preinitiation complex] GO:0140223[general transcription initiation factor activity] GO:0140297[DNA-binding transcription factor binding]
The Human Protein Atlas project is funded
