GENERAL INFORMATIONi
Gene namei VEGFA
Synonyms VEGF, VEGF-A, VPF
Gene descriptioni Vascular endothelial growth factor A
Protein classi Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Human disease related genes
Plasma proteins
RAS pathway related proteins
Predicted locationi Secreted, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 6
Cytoband p21.1
Chromosome location (bp) 43770184 - 43786487
Number of transcriptsi 20
Ensembl ENSG00000112715 (version 109)
Entrez gene 7422
HGNC HGNC:12680
UniProt P15692 (UniProt - Evidence at protein level)
neXtProt NX_P15692
GeneCards VEGFA
Antibodypedia VEGFA antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor 1. show less
Molecular function (UniProt)i Developmental protein, Growth factor, Heparin-binding, Mitogen
Biological process (UniProt)i Angiogenesis, Differentiation
Gene summary (Entrez)i This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. [provided by RefSeq, Jun 2020] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
VEGFA-201
ENSP00000230480
ENST00000230480
A2A2V4
[Direct mapping] Vascular endothelial growth factor A
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0048018 [receptor ligand activity]
GO:0051781 [positive regulation of cell division]
Show all
 163 aa
19 kDa 		No 0
VEGFA-202
ENSP00000317598
ENST00000324450
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
A0A0A0MR43
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 317 aa
34.4 kDa 		No 0
VEGFA-203
ENSP00000361125
ENST00000372055
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
J3KPA4
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 412 aa
45.5 kDa 		No 0
VEGFA-204
ENSP00000361134
ENST00000372064
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
A0A0A0MRQ4
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 327 aa
35.6 kDa 		No 0
VEGFA-205
ENSP00000361137
ENST00000372067
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
H3BLW8
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 371 aa
40.7 kDa 		No 0
VEGFA-206
ENSP00000361148
ENST00000372077
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 147 aa
17.2 kDa 		Yes 0
VEGFA-207
ENSP00000389864
ENST00000413642
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
A0A0A0MSI7
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 389 aa
42.8 kDa 		No 0
VEGFA-208
ENSP00000388663
ENST00000417285
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
A0A0A0MSH7
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 354 aa
38.6 kDa 		No 0
VEGFA-209
ENSP00000388465
ENST00000425836
A0A0A0MSH5
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0048018 [receptor ligand activity]
GO:0051781 [positive regulation of cell division]
Show all
 393 aa
42.9 kDa 		No 0
VEGFA-210
ENSP00000409911
ENST00000457104
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 137 aa
16 kDa 		Yes 0
VEGFA-213
ENSP00000421561
ENST00000482630
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
A0A0A0MTB2
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 371 aa
40.7 kDa 		No 0
VEGFA-218
ENSP00000430829
ENST00000518689
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 209 aa
24.4 kDa 		Yes 0
VEGFA-219
ENSP00000430002
ENST00000518824
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 191 aa
22.3 kDa 		Yes 0
VEGFA-220
ENSP00000430594
ENST00000519767
H0YBZ0
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell population proliferation]
GO:0016020 [membrane]
GO:0048018 [receptor ligand activity]
GO:0051781 [positive regulation of cell division]
Show all
 323 aa
35.3 kDa 		No 0
VEGFA-221
ENSP00000429592
ENST00000520265
H0YBI8
[Direct mapping] Vascular endothelial growth factor A
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0048018 [receptor ligand activity]
GO:0051781 [positive regulation of cell division]
Show all
 111 aa
12.8 kDa 		No 0
VEGFA-222
ENSP00000428321
ENST00000520948
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
A0A024RD37
[Target identity:100%; Query identity:100%] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 215 aa
25.2 kDa 		Yes 0
VEGFA-223
ENSP00000429008
ENST00000523125
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 174 aa
20.2 kDa 		Yes 0
VEGFA-224
ENSP00000430479
ENST00000523873
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
A0A024RD33
[Target identity:100%; Query identity:100%] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
Show all
 232 aa
27 kDa 		Yes 0
VEGFA-225
ENSP00000429643
ENST00000523950
P15692
[Direct mapping] Vascular endothelial growth factor A
Show all
A0A0Y0IMM4
[Target identity:100%; Query identity:100%] Vascular endothelial growth factor A
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002575 [basophil chemotaxis]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038089 [positive regulation of cell migration by vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0038191 [neuropilin binding]
GO:0042056 [chemoattractant activity]
GO:0042327 [positive regulation of phosphorylation]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905278 [positive regulation of epithelial tube formation]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
GO:2000573 [positive regulation of DNA biosynthetic process]
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 191 aa
22.3 kDa 		Yes 0
VEGFA-226
ENSP00000500082
ENST00000672860
P15692
[Direct mapping] Vascular endothelial growth factor A
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A0A5F9ZH41
[Direct mapping] Vascular endothelial growth factor A
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Musculoskeletal diseases
   Skeletal diseases
   Nervous system diseases
   Eye disease
   Other nervous and sensory system diseases
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001822 [kidney development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001968 [fibronectin binding]
GO:0002040 [sprouting angiogenesis]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002092 [positive regulation of receptor internalization]
GO:0002687 [positive regulation of leukocyte migration]
GO:0003007 [heart morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003169 [coronary vein morphogenesis]
GO:0005125 [cytokine activity]
GO:0005161 [platelet-derived growth factor receptor binding]
GO:0005172 [vascular endothelial growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005912 [adherens junction]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0007595 [lactation]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010749 [regulation of nitric oxide mediated signal transduction]
GO:0016020 [membrane]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030224 [monocyte differentiation]
GO:0030225 [macrophage differentiation]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0031077 [post-embryonic camera-type eye development]
GO:0031093 [platelet alpha granule lumen]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032147 [activation of protein kinase activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035148 [tube formation]
GO:0035767 [endothelial cell chemotaxis]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036303 [lymph vessel morphogenesis]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0038084 [vascular endothelial growth factor signaling pathway]
GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway]
GO:0038190 [VEGF-activated neuropilin signaling pathway]
GO:0042056 [chemoattractant activity]
GO:0042462 [eye photoreceptor cell development]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0043129 [surfactant homeostasis]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043183 [vascular endothelial growth factor receptor 1 binding]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048018 [receptor ligand activity]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0048844 [artery morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050840 [extracellular matrix binding]
GO:0050918 [positive chemotaxis]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0055013 [cardiac muscle cell development]
GO:0060319 [primitive erythrocyte differentiation]
GO:0060749 [mammary gland alveolus development]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060982 [coronary artery morphogenesis]
GO:0061042 [vascular wound healing]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071679 [commissural neuron axon guidance]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0090259 [regulation of retinal ganglion cell axon guidance]
GO:0097475 [motor neuron migration]
GO:0097533 [cellular stress response to acid chemical]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902336 [positive regulation of retinal ganglion cell axon guidance]
GO:1903141 [negative regulation of establishment of endothelial barrier]
GO:1903392 [negative regulation of adherens junction organization]
GO:1903572 [positive regulation of protein kinase D signaling]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1905604 [negative regulation of blood-brain barrier permeability]
GO:1990150 [VEGF-A complex]
GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
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 395 aa
43.6 kDa 		No 0

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