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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q31.1
Chromosome location (bp)
132673986 - 132682678
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses 1,2. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1 3. Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes 4. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (By similarity). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells 5,6,7. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine, Growth factor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
B-cell activation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001774[microglial cell activation] GO:0002227[innate immune response in mucosa] GO:0002230[positive regulation of defense response to virus by host] GO:0002674[negative regulation of acute inflammatory response] GO:0002677[negative regulation of chronic inflammatory response] GO:0005125[cytokine activity] GO:0005126[cytokine receptor binding] GO:0005136[interleukin-4 receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006955[immune response] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008203[cholesterol metabolic process] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010633[negative regulation of epithelial cell migration] GO:0016239[positive regulation of macroautophagy] GO:0030183[B cell differentiation] GO:0030335[positive regulation of cell migration] GO:0030890[positive regulation of B cell proliferation] GO:0031296[B cell costimulation] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032733[positive regulation of interleukin-10 production] GO:0032736[positive regulation of interleukin-13 production] GO:0042092[type 2 immune response] GO:0042102[positive regulation of T cell proliferation] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042116[macrophage activation] GO:0042325[regulation of phosphorylation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042976[activation of Janus kinase activity] GO:0043011[myeloid dendritic cell differentiation] GO:0043031[negative regulation of macrophage activation] GO:0043066[negative regulation of apoptotic process] GO:0043306[positive regulation of mast cell degranulation] GO:0045064[T-helper 2 cell differentiation] GO:0045191[regulation of isotype switching] GO:0045348[positive regulation of MHC class II biosynthetic process] GO:0045582[positive regulation of T cell differentiation] GO:0045671[negative regulation of osteoclast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048260[positive regulation of receptor-mediated endocytosis] GO:0048295[positive regulation of isotype switching to IgE isotypes] GO:0048304[positive regulation of isotype switching to IgG isotypes] GO:0050728[negative regulation of inflammatory response] GO:0050776[regulation of immune response] GO:0071677[positive regulation of mononuclear cell migration] GO:0097028[dendritic cell differentiation] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0120162[positive regulation of cold-induced thermogenesis] GO:0150076[neuroinflammatory response] GO:0150079[negative regulation of neuroinflammatory response] GO:1900223[positive regulation of amyloid-beta clearance] GO:1901741[positive regulation of myoblast fusion] GO:1901857[positive regulation of cellular respiration] GO:1903660[negative regulation of complement-dependent cytotoxicity] GO:1903845[negative regulation of cellular response to transforming growth factor beta stimulus] GO:2000320[negative regulation of T-helper 17 cell differentiation] GO:2000352[negative regulation of endothelial cell apoptotic process] GO:2000424[positive regulation of eosinophil chemotaxis] GO:2000553[positive regulation of T-helper 2 cell cytokine production] GO:2001171[positive regulation of ATP biosynthetic process] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001774[microglial cell activation] GO:0002227[innate immune response in mucosa] GO:0002230[positive regulation of defense response to virus by host] GO:0002674[negative regulation of acute inflammatory response] GO:0002677[negative regulation of chronic inflammatory response] GO:0005125[cytokine activity] GO:0005126[cytokine receptor binding] GO:0005136[interleukin-4 receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006955[immune response] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008203[cholesterol metabolic process] GO:0008284[positive regulation of cell population proliferation] GO:0010628[positive regulation of gene expression] GO:0010633[negative regulation of epithelial cell migration] GO:0016239[positive regulation of macroautophagy] GO:0030183[B cell differentiation] GO:0030335[positive regulation of cell migration] GO:0030890[positive regulation of B cell proliferation] GO:0031296[B cell costimulation] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032733[positive regulation of interleukin-10 production] GO:0032736[positive regulation of interleukin-13 production] GO:0042092[type 2 immune response] GO:0042102[positive regulation of T cell proliferation] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042116[macrophage activation] GO:0042325[regulation of phosphorylation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042976[activation of Janus kinase activity] GO:0043011[myeloid dendritic cell differentiation] GO:0043031[negative regulation of macrophage activation] GO:0043066[negative regulation of apoptotic process] GO:0043306[positive regulation of mast cell degranulation] GO:0045064[T-helper 2 cell differentiation] GO:0045191[regulation of isotype switching] GO:0045348[positive regulation of MHC class II biosynthetic process] GO:0045582[positive regulation of T cell differentiation] GO:0045671[negative regulation of osteoclast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048260[positive regulation of receptor-mediated endocytosis] GO:0048295[positive regulation of isotype switching to IgE isotypes] GO:0048304[positive regulation of isotype switching to IgG isotypes] GO:0050728[negative regulation of inflammatory response] GO:0050776[regulation of immune response] GO:0071677[positive regulation of mononuclear cell migration] GO:0097028[dendritic cell differentiation] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:0120162[positive regulation of cold-induced thermogenesis] GO:0150076[neuroinflammatory response] GO:0150079[negative regulation of neuroinflammatory response] GO:1900223[positive regulation of amyloid-beta clearance] GO:1901741[positive regulation of myoblast fusion] GO:1901857[positive regulation of cellular respiration] GO:1903660[negative regulation of complement-dependent cytotoxicity] GO:1903845[negative regulation of cellular response to transforming growth factor beta stimulus] GO:2000320[negative regulation of T-helper 17 cell differentiation] GO:2000352[negative regulation of endothelial cell apoptotic process] GO:2000424[positive regulation of eosinophil chemotaxis] GO:2000553[positive regulation of T-helper 2 cell cytokine production] GO:2001171[positive regulation of ATP biosynthetic process] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
