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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q35.2
Chromosome location (bp)
173314723 - 173328447
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Has an anti-hypocalcemic action on calcium and phosphate homeostasis....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hormone
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q6FHC9 [Target identity:100%; Query identity:100%] STC2 protein; Stanniocalcin 2, isoform CRA_a; cDNA FLJ14757 fis, clone NT2RP3003242, highly similar to Stanniocalcin-2; cDNA FLJ38572 fis, clone HCHON2006786, highly similar to Stanniocalcin-2; cDNA PSEC0097 fis, clone NT2RP2002139, highly similar to Stanniocalcin-2
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005179[hormone activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005794[Golgi apparatus] GO:0006874[cellular calcium ion homeostasis] GO:0006979[response to oxidative stress] GO:0007566[embryo implantation] GO:0010629[negative regulation of gene expression] GO:0019899[enzyme binding] GO:0020037[heme binding] GO:0030968[endoplasmic reticulum unfolded protein response] GO:0033280[response to vitamin D] GO:0034976[response to endoplasmic reticulum stress] GO:0040015[negative regulation of multicellular organism growth] GO:0042803[protein homodimerization activity] GO:0043434[response to peptide hormone] GO:0046697[decidualization] GO:0046885[regulation of hormone biosynthetic process] GO:0048471[perinuclear region of cytoplasm] GO:0055074[calcium ion homeostasis] GO:0071456[cellular response to hypoxia] GO:2001256[regulation of store-operated calcium entry]
The Human Protein Atlas project is funded
