GENERAL INFORMATIONi
Gene namei HES1
Synonyms bHLHb39, FLJ20408, HES-1, HRY
Gene descriptioni Hes family bHLH transcription factor 1
Protein classi Plasma proteins
Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 3
Cytoband q29
Chromosome location (bp) 194136148 - 194138732
Number of transcriptsi 1
Ensembl ENSG00000114315 (version 109)
Entrez gene 3280
HGNC HGNC:5192
UniProt Q14469 (UniProt - Evidence at protein level)
neXtProt NX_Q14469
GeneCards HES1
Antibodypedia HES1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'- CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. show less
Molecular function (UniProt)i DNA-binding, Repressor
Biological process (UniProt)i Transcription, Transcription regulation
Gene summary (Entrez)i This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
HES1-201
ENSP00000232424
ENST00000232424
Q14469
[Direct mapping] Transcription factor HES-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001217 [DNA-binding transcription repressor activity]
GO:0001222 [transcription corepressor binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001701 [in utero embryonic development]
GO:0001709 [cell fate determination]
GO:0001889 [liver development]
GO:0002085 [inhibition of neuroepithelial cell differentiation]
GO:0003143 [embryonic heart tube morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003266 [regulation of secondary heart field cardioblast proliferation]
GO:0003281 [ventricular septum development]
GO:0003310 [pancreatic A cell differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007155 [cell adhesion]
GO:0007219 [Notch signaling pathway]
GO:0007224 [smoothened signaling pathway]
GO:0007389 [pattern specification process]
GO:0007399 [nervous system development]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008432 [JUN kinase binding]
GO:0009952 [anterior/posterior pattern specification]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010977 [negative regulation of neuron projection development]
GO:0014070 [response to organic cyclic compound]
GO:0016363 [nuclear matrix]
GO:0016477 [cell migration]
GO:0021537 [telencephalon development]
GO:0021555 [midbrain-hindbrain boundary morphogenesis]
GO:0021557 [oculomotor nerve development]
GO:0021558 [trochlear nerve development]
GO:0021575 [hindbrain morphogenesis]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021870 [Cajal-Retzius cell differentiation]
GO:0021915 [neural tube development]
GO:0021983 [pituitary gland development]
GO:0021984 [adenohypophysis development]
GO:0030182 [neuron differentiation]
GO:0030324 [lung development]
GO:0030509 [BMP signaling pathway]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0030901 [midbrain development]
GO:0031016 [pancreas development]
GO:0032991 [protein-containing complex]
GO:0035019 [somatic stem cell population maintenance]
GO:0035315 [hair cell differentiation]
GO:0035881 [amacrine cell differentiation]
GO:0035883 [enteroendocrine cell differentiation]
GO:0035909 [aorta morphogenesis]
GO:0035910 [ascending aorta morphogenesis]
GO:0042098 [T cell proliferation]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042491 [inner ear auditory receptor cell differentiation]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043254 [regulation of protein-containing complex assembly]
GO:0043279 [response to alkaloid]
GO:0043388 [positive regulation of DNA binding]
GO:0043398 [HLH domain binding]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0044877 [protein-containing complex binding]
GO:0045165 [cell fate commitment]
GO:0045596 [negative regulation of cell differentiation]
GO:0045598 [regulation of fat cell differentiation]
GO:0045608 [negative regulation of inner ear auditory receptor cell differentiation]
GO:0045664 [regulation of neuron differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045687 [positive regulation of glial cell differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045977 [positive regulation of mitotic cell cycle, embryonic]
GO:0046331 [lateral inhibition]
GO:0046425 [regulation of receptor signaling pathway via JAK-STAT]
GO:0046427 [positive regulation of receptor signaling pathway via JAK-STAT]
GO:0046983 [protein dimerization activity]
GO:0048469 [cell maturation]
GO:0048505 [regulation of timing of cell differentiation]
GO:0048538 [thymus development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0048715 [negative regulation of oligodendrocyte differentiation]
GO:0048844 [artery morphogenesis]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0050768 [negative regulation of neurogenesis]
GO:0051087 [chaperone binding]
GO:0060122 [inner ear receptor cell stereocilium organization]
GO:0060164 [regulation of timing of neuron differentiation]
GO:0060253 [negative regulation of glial cell proliferation]
GO:0060412 [ventricular septum morphogenesis]
GO:0060675 [ureteric bud morphogenesis]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061009 [common bile duct development]
GO:0061101 [neuroendocrine cell differentiation]
GO:0061102 [stomach neuroendocrine cell differentiation]
GO:0061106 [negative regulation of stomach neuroendocrine cell differentiation]
GO:0061309 [cardiac neural crest cell development involved in outflow tract morphogenesis]
GO:0061626 [pharyngeal arch artery morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0065003 [protein-containing complex assembly]
GO:0070888 [E-box binding]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071398 [cellular response to fatty acid]
GO:0071820 [N-box binding]
GO:0072012 [glomerulus vasculature development]
GO:0072049 [comma-shaped body morphogenesis]
GO:0072050 [S-shaped body morphogenesis]
GO:0072141 [renal interstitial fibroblast development]
GO:0072282 [metanephric nephron tubule morphogenesis]
GO:0090102 [cochlea development]
GO:0090162 [establishment of epithelial cell polarity]
GO:0090281 [negative regulation of calcium ion import]
GO:0097066 [response to thyroid hormone]
GO:0097084 [vascular associated smooth muscle cell development]
GO:0097150 [neuronal stem cell population maintenance]
GO:1902870 [negative regulation of amacrine cell differentiation]
GO:1905934 [negative regulation of cell fate determination]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000227 [negative regulation of pancreatic A cell differentiation]
GO:2000737 [negative regulation of stem cell differentiation]
GO:2000974 [negative regulation of pro-B cell differentiation]
GO:2000978 [negative regulation of forebrain neuron differentiation]
GO:2000981 [negative regulation of inner ear receptor cell differentiation]
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 280 aa
29.5 kDa 		No 0

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