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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p21.31
Chromosome location (bp)
50226292 - 50259362
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transducer
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell cycle, Cell division
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P04899 [Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-2
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of endocrine organs Cardiovascular diseases Cardiac diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P04899 [Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-2
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of endocrine organs Cardiovascular diseases Cardiac diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001664[G protein-coupled receptor binding] GO:0001973[G protein-coupled adenosine receptor signaling pathway] GO:0003924[GTPase activity] GO:0005515[protein binding] GO:0005525[GTP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005834[heterotrimeric G-protein complex] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0007049[cell cycle] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007188[adenylate cyclase-modulating G protein-coupled receptor signaling pathway] GO:0007189[adenylate cyclase-activating G protein-coupled receptor signaling pathway] GO:0007193[adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway] GO:0007194[negative regulation of adenylate cyclase activity] GO:0007213[G protein-coupled acetylcholine receptor signaling pathway] GO:0007214[gamma-aminobutyric acid signaling pathway] GO:0007584[response to nutrient] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0019001[guanyl nucleotide binding] GO:0030335[positive regulation of cell migration] GO:0030425[dendrite] GO:0030496[midbody] GO:0031683[G-protein beta/gamma-subunit complex binding] GO:0032930[positive regulation of superoxide anion generation] GO:0033864[positive regulation of NAD(P)H oxidase activity] GO:0035810[positive regulation of urine volume] GO:0035815[positive regulation of renal sodium excretion] GO:0044297[cell body] GO:0045121[membrane raft] GO:0045202[synapse] GO:0045955[negative regulation of calcium ion-dependent exocytosis] GO:0046628[positive regulation of insulin receptor signaling pathway] GO:0046872[metal ion binding] GO:0050805[negative regulation of synaptic transmission] GO:0051301[cell division] GO:0051924[regulation of calcium ion transport] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0098992[neuronal dense core vesicle] GO:0140199[negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process] GO:1903561[extracellular vesicle] GO:1903614[negative regulation of protein tyrosine phosphatase activity] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:2000179[positive regulation of neural precursor cell proliferation] GO:2001234[negative regulation of apoptotic signaling pathway]
P04899 [Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-2
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of endocrine organs Cardiovascular diseases Cardiac diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P04899 [Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-2
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of endocrine organs Cardiovascular diseases Cardiac diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P04899 [Direct mapping] Guanine nucleotide-binding protein G(i) subunit alpha-2
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of endocrine organs Cardiovascular diseases Cardiac diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
