GENERAL INFORMATIONi
Gene namei FN1
Synonyms CIG, FINC, GFND2, LETS, MSF
Gene descriptioni Fibronectin 1
Protein classi Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Human disease related genes
Plasma proteins
Predicted locationi Secreted, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 2
Cytoband q35
Chromosome location (bp) 215360440 - 215436073
Number of transcriptsi 13
Ensembl ENSG00000115414 (version 109)
Entrez gene 2335
HGNC HGNC:3778
UniProt P02751 (UniProt - Evidence at protein level)
neXtProt NX_P02751
GeneCards FN1
Antibodypedia FN1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin 1, 2, 3, 4. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape 5, 6, 7, 8. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation 9. show less
Molecular function (UniProt)i Heparin-binding
Biological process (UniProt)i Acute phase, Angiogenesis, Cell adhesion, Cell shape
Gene summary (Entrez)i This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
FN1-201
ENSP00000323534
ENST00000323926
P02751
[Direct mapping] Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019899 [enzyme binding]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051087 [chaperone binding]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:0110165 [cellular anatomical entity]
GO:0150102 [negative regulation of monocyte activation]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
 2446 aa
268.9 kDa 		Yes 0
FN1-202
ENSP00000338200
ENST00000336916
P02751
[Direct mapping] Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019899 [enzyme binding]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051087 [chaperone binding]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:0110165 [cellular anatomical entity]
GO:0150102 [negative regulation of monocyte activation]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
 2355 aa
259.2 kDa 		Yes 0
FN1-203
ENSP00000346839
ENST00000354785
P02751
[Direct mapping] Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016324 [apical plasma membrane]
GO:0016504 [peptidase activator activity]
GO:0018149 [peptide cross-linking]
GO:0019899 [enzyme binding]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042060 [wound healing]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0045773 [positive regulation of axon extension]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051087 [chaperone binding]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:0110165 [cellular anatomical entity]
GO:0150102 [negative regulation of monocyte activation]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
 2477 aa
272.3 kDa 		Yes 0
FN1-204
ENSP00000348285
ENST00000356005
P02751
[Direct mapping] Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019899 [enzyme binding]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051087 [chaperone binding]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:0110165 [cellular anatomical entity]
GO:0150102 [negative regulation of monocyte activation]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
 2296 aa
252.8 kDa 		Yes 0
FN1-205
ENSP00000350534
ENST00000357867
P02751
[Direct mapping] Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019899 [enzyme binding]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051087 [chaperone binding]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:0110165 [cellular anatomical entity]
GO:0150102 [negative regulation of monocyte activation]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
 2176 aa
239.6 kDa 		Yes 0
FN1-206
ENSP00000352696
ENST00000359671
P02751
[Direct mapping] Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019899 [enzyme binding]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051087 [chaperone binding]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:0110165 [cellular anatomical entity]
GO:0150102 [negative regulation of monocyte activation]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
 2386 aa
262.6 kDa 		Yes 0
FN1-207
ENSP00000394423
ENST00000421182
P02751
[Direct mapping] Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019899 [enzyme binding]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051087 [chaperone binding]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:0110165 [cellular anatomical entity]
GO:0150102 [negative regulation of monocyte activation]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
 2240 aa
246.7 kDa 		Yes 0
FN1-208
ENSP00000398907
ENST00000426059
P02751
[Direct mapping] Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019899 [enzyme binding]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051087 [chaperone binding]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:0110165 [cellular anatomical entity]
GO:0150102 [negative regulation of monocyte activation]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
 657 aa
73.7 kDa 		Yes 0
FN1-209
ENSP00000399538
ENST00000432072
P02751
[Direct mapping] Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019899 [enzyme binding]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051087 [chaperone binding]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:0110165 [cellular anatomical entity]
GO:0150102 [negative regulation of monocyte activation]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
 2267 aa
249.3 kDa 		Yes 0
FN1-210
ENSP00000392565
ENST00000438981
H0Y4K8
[Direct mapping] Fibronectin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 241 aa
26.6 kDa 		No 0
FN1-211
ENSP00000415018
ENST00000443816
P02751
[Direct mapping] Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019899 [enzyme binding]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051087 [chaperone binding]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:0110165 [cellular anatomical entity]
GO:0150102 [negative regulation of monocyte activation]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
 2265 aa
249.4 kDa 		Yes 0
FN1-212
ENSP00000410422
ENST00000446046
P02751
[Direct mapping] Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019899 [enzyme binding]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051087 [chaperone binding]
GO:0051702 [biological process involved in interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:0110165 [cellular anatomical entity]
GO:0150102 [negative regulation of monocyte activation]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
 2330 aa
256.5 kDa 		Yes 0
FN1-213
ENSP00000416139
ENST00000456923
H0Y7Z1
[Direct mapping] Fibronectin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0008201 [heparin binding]
GO:0008360 [regulation of cell shape]
Show all
 1103 aa
120.8 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
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contact@proteinatlas.org