Protein interactions for ACADM - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACADM
Gene descriptionⁱ Full gene name according to HGNC.	Acyl-CoA dehydrogenase medium chain
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry.
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mitochondria (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (liver, skeletal muscle, tongue)
Tau specificity score (RNA)ⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.38
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Mitochondria
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

INTERACTION SUMMARYⁱ In the Interaction summary a network plot of the gene's interaction partners is shown with nodes representing genes and edges representing the interaction type and the confidence (MI score) for the interaction. The type of interaction (direct interaction or physical association) is reflected by the colour of the edges, while the confidence of the interaction is reflected by the thickness of the edges. Scores larger than 0.6 (high confidence) have a thicker line than scores between 0.45 and 0.6 (medium confidence). The highlight bar in the top of the plot can be used to colour the nodes according to subcellular location (based on data in the Subcellular section), predicted location (based on signalpeptide and transmembrane region predictions), tissue specificity (based on RNA tissue expression profiles) or proteinclass. Nodes can also be highlighted using the top left Filter option in which a query of choice can be built to for example label all nodes that are tissue enriched in both human and mouse brain or those that belongs to a certain tissue expression cluster. The expression cluster for the gene is stated in the box Human Protein Atlas Information above the network plot. Click on Filter in the top left in the plot to find the query builder and some example queries.
ACADM has no defined protein interactions.

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene ACADM is associated with 106 reactions in 13 different subsystems, and present in the compartments: Cytosol, Mitochondria, Nucleus. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Fatty acid oxidation	Cytosol, Endoplasmic reticulum, Peroxisome, Mitochondria, Extracellular	69	373	41
Beta oxidation of even-chain fatty acids (mitochondrial)	Mitochondria	13	68	31
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)	Mitochondria	14	26	4
Beta oxidation of branched-chain fatty acids (mitochondrial)	Mitochondria	10	23	3
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)	Mitochondria	14	30	5
Purine metabolism	Cytosol, Extracellular, Lysosome, Mitochondria, Nucleus, Peroxisome	139	99	1
Omega-6 fatty acid metabolism	Cytosol, Mitochondria, Peroxisome	39	56	4
Beta oxidation of odd-chain fatty acids (mitochondrial)	Mitochondria	12	47	8
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)	Mitochondria	16	28	4
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	587	1603	2
Valine, leucine, and isoleucine metabolism	Mitochondria, Cytosol, Peroxisome	73	71	1
Butanoate metabolism	Mitochondria, Cytosol, Peroxisome	19	22	1
Propanoate metabolism	Cytosol, Mitochondria, Peroxisome	45	35	1