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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes Disease related genes Human disease related genes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q23.3
Chromosome location (bp)
116835751 - 116837622
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Metabolic proteins MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Human disease related genes Cardiovascular diseases Vascular diseases Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540[amyloid-beta binding] GO:0001932[regulation of protein phosphorylation] GO:0001935[endothelial cell proliferation] GO:0002719[negative regulation of cytokine production involved in immune response] GO:0005102[signaling receptor binding] GO:0005319[lipid transporter activity] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005769[early endosome] GO:0005788[endoplasmic reticulum lumen] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006644[phospholipid metabolic process] GO:0006656[phosphatidylcholine biosynthetic process] GO:0006695[cholesterol biosynthetic process] GO:0006869[lipid transport] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0008035[high-density lipoprotein particle binding] GO:0008202[steroid metabolic process] GO:0008203[cholesterol metabolic process] GO:0008211[glucocorticoid metabolic process] GO:0008289[lipid binding] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0010875[positive regulation of cholesterol efflux] GO:0010898[positive regulation of triglyceride catabolic process] GO:0010903[negative regulation of very-low-density lipoprotein particle remodeling] GO:0015485[cholesterol binding] GO:0018158[protein oxidation] GO:0018206[peptidyl-methionine modification] GO:0019899[enzyme binding] GO:0019915[lipid storage] GO:0030139[endocytic vesicle] GO:0030300[regulation of intestinal cholesterol absorption] GO:0030301[cholesterol transport] GO:0030325[adrenal gland development] GO:0031072[heat shock protein binding] GO:0031210[phosphatidylcholine binding] GO:0031410[cytoplasmic vesicle] GO:0032489[regulation of Cdc42 protein signal transduction] GO:0032691[negative regulation of interleukin-1 beta production] GO:0033344[cholesterol efflux] GO:0033700[phospholipid efflux] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0034190[apolipoprotein receptor binding] GO:0034191[apolipoprotein A-I receptor binding] GO:0034361[very-low-density lipoprotein particle] GO:0034364[high-density lipoprotein particle] GO:0034366[spherical high-density lipoprotein particle] GO:0034372[very-low-density lipoprotein particle remodeling] GO:0034375[high-density lipoprotein particle remodeling] GO:0034380[high-density lipoprotein particle assembly] GO:0034384[high-density lipoprotein particle clearance] GO:0034774[secretory granule lumen] GO:0035025[positive regulation of Rho protein signal transduction] GO:0042157[lipoprotein metabolic process] GO:0042158[lipoprotein biosynthetic process] GO:0042627[chylomicron] GO:0042632[cholesterol homeostasis] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043534[blood vessel endothelial cell migration] GO:0043691[reverse cholesterol transport] GO:0045499[chemorepellent activity] GO:0045723[positive regulation of fatty acid biosynthetic process] GO:0046470[phosphatidylcholine metabolic process] GO:0046889[positive regulation of lipid biosynthetic process] GO:0050728[negative regulation of inflammatory response] GO:0050766[positive regulation of phagocytosis] GO:0050821[protein stabilization] GO:0050919[negative chemotaxis] GO:0051006[positive regulation of lipoprotein lipase activity] GO:0051180[vitamin transport] GO:0051345[positive regulation of hydrolase activity] GO:0051346[negative regulation of hydrolase activity] GO:0051496[positive regulation of stress fiber assembly] GO:0055091[phospholipid homeostasis] GO:0060228[phosphatidylcholine-sterol O-acyltransferase activator activity] GO:0060354[negative regulation of cell adhesion molecule production] GO:0060761[negative regulation of response to cytokine stimulus] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070328[triglyceride homeostasis] GO:0070508[cholesterol import] GO:0070653[high-density lipoprotein particle receptor binding] GO:0071682[endocytic vesicle lumen] GO:0071813[lipoprotein particle binding] GO:0072562[blood microparticle] GO:0090205[positive regulation of cholesterol metabolic process] GO:0120009[intermembrane lipid transfer] GO:0120020[cholesterol transfer activity] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1902995[positive regulation of phospholipid efflux] GO:1903561[extracellular vesicle] GO:1905920[positive regulation of CoA-transferase activity]
Metabolic proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
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