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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p15.4
Chromosome location (bp)
5596109 - 5612958
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway 1,2. In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response 3. Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhanced RIGI-mediated innate antiviral immune response 4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9C030 [Direct mapping] Tripartite motif-containing protein 6
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000209[protein polyubiquitination] GO:0002230[positive regulation of defense response to virus by host] GO:0002720[positive regulation of cytokine production involved in immune response] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010508[positive regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030674[protein-macromolecule adaptor activity] GO:0032496[response to lipopolysaccharide] GO:0032880[regulation of protein localization] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035458[cellular response to interferon-beta] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0046596[regulation of viral entry into host cell] GO:0046872[metal ion binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060340[positive regulation of type I interferon-mediated signaling pathway] GO:0061630[ubiquitin protein ligase activity] GO:1990782[protein tyrosine kinase binding] GO:2000679[positive regulation of transcription regulatory region DNA binding]
Q9C030 [Direct mapping] Tripartite motif-containing protein 6
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000209[protein polyubiquitination] GO:0002230[positive regulation of defense response to virus by host] GO:0002720[positive regulation of cytokine production involved in immune response] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010508[positive regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030674[protein-macromolecule adaptor activity] GO:0032496[response to lipopolysaccharide] GO:0032880[regulation of protein localization] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035458[cellular response to interferon-beta] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0045892[negative regulation of DNA-templated transcription] GO:0046596[regulation of viral entry into host cell] GO:0046872[metal ion binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060340[positive regulation of type I interferon-mediated signaling pathway] GO:0061630[ubiquitin protein ligase activity] GO:0098586[cellular response to virus] GO:0140297[DNA-binding transcription factor binding] GO:1990782[protein tyrosine kinase binding] GO:2000679[positive regulation of transcription regulatory region DNA binding] GO:2000737[negative regulation of stem cell differentiation]
Q9C030 [Direct mapping] Tripartite motif-containing protein 6
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000209[protein polyubiquitination] GO:0002230[positive regulation of defense response to virus by host] GO:0002720[positive regulation of cytokine production involved in immune response] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010508[positive regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030674[protein-macromolecule adaptor activity] GO:0032496[response to lipopolysaccharide] GO:0032880[regulation of protein localization] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035458[cellular response to interferon-beta] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0046596[regulation of viral entry into host cell] GO:0046872[metal ion binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060340[positive regulation of type I interferon-mediated signaling pathway] GO:0061630[ubiquitin protein ligase activity] GO:1990782[protein tyrosine kinase binding] GO:2000679[positive regulation of transcription regulatory region DNA binding]
Q9C030 [Direct mapping] Tripartite motif-containing protein 6
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000209[protein polyubiquitination] GO:0002230[positive regulation of defense response to virus by host] GO:0002720[positive regulation of cytokine production involved in immune response] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010508[positive regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030674[protein-macromolecule adaptor activity] GO:0032496[response to lipopolysaccharide] GO:0032880[regulation of protein localization] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035458[cellular response to interferon-beta] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0046596[regulation of viral entry into host cell] GO:0046872[metal ion binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060340[positive regulation of type I interferon-mediated signaling pathway] GO:0061630[ubiquitin protein ligase activity] GO:1990782[protein tyrosine kinase binding] GO:2000679[positive regulation of transcription regulatory region DNA binding]
Q9C030 [Direct mapping] Tripartite motif-containing protein 6
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000209[protein polyubiquitination] GO:0002230[positive regulation of defense response to virus by host] GO:0002720[positive regulation of cytokine production involved in immune response] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010508[positive regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030674[protein-macromolecule adaptor activity] GO:0032496[response to lipopolysaccharide] GO:0032880[regulation of protein localization] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035458[cellular response to interferon-beta] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0046596[regulation of viral entry into host cell] GO:0046872[metal ion binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060340[positive regulation of type I interferon-mediated signaling pathway] GO:0061630[ubiquitin protein ligase activity] GO:1990782[protein tyrosine kinase binding] GO:2000679[positive regulation of transcription regulatory region DNA binding]
Q9C030 [Direct mapping] Tripartite motif-containing protein 6
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000209[protein polyubiquitination] GO:0002230[positive regulation of defense response to virus by host] GO:0002720[positive regulation of cytokine production involved in immune response] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0008270[zinc ion binding] GO:0010468[regulation of gene expression] GO:0010508[positive regulation of autophagy] GO:0010629[negative regulation of gene expression] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019901[protein kinase binding] GO:0030674[protein-macromolecule adaptor activity] GO:0032496[response to lipopolysaccharide] GO:0032880[regulation of protein localization] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035458[cellular response to interferon-beta] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045087[innate immune response] GO:0046596[regulation of viral entry into host cell] GO:0046872[metal ion binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060340[positive regulation of type I interferon-mediated signaling pathway] GO:0061630[ubiquitin protein ligase activity] GO:1990782[protein tyrosine kinase binding] GO:2000679[positive regulation of transcription regulatory region DNA binding]
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