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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q21
Chromosome location (bp)
58519951 - 58629885
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)- containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Enables armadillo repeat domain binding activity; molecular adaptor activity; and nuclear receptor binding activity. Contributes to poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of gene expression. Located in P-body and cytosol. Part of CCR4-NOT complex. Implicated in holoprosencephaly. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000288[nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289[nuclear-transcribed mRNA poly(A) tail shortening] GO:0000932[P-body] GO:0001829[trophectodermal cell differentiation] GO:0003723[RNA binding] GO:0004535[poly(A)-specific ribonuclease activity] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006417[regulation of translation] GO:0010606[positive regulation of cytoplasmic mRNA processing body assembly] GO:0016020[membrane] GO:0017148[negative regulation of translation] GO:0019904[protein domain specific binding] GO:0030014[CCR4-NOT complex] GO:0030015[CCR4-NOT core complex] GO:0030331[nuclear estrogen receptor binding] GO:0031047[gene silencing by RNA] GO:0033147[negative regulation of intracellular estrogen receptor signaling pathway] GO:0035195[miRNA-mediated gene silencing] GO:0042974[nuclear retinoic acid receptor binding] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:0060090[molecular adaptor activity] GO:0060213[positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:0061014[positive regulation of mRNA catabolic process] GO:0070016[armadillo repeat domain binding] GO:0090503[RNA phosphodiester bond hydrolysis, exonucleolytic] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:2000036[regulation of stem cell population maintenance]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000288[nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289[nuclear-transcribed mRNA poly(A) tail shortening] GO:0000932[P-body] GO:0003723[RNA binding] GO:0004535[poly(A)-specific ribonuclease activity] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006417[regulation of translation] GO:0010606[positive regulation of cytoplasmic mRNA processing body assembly] GO:0016020[membrane] GO:0017148[negative regulation of translation] GO:0019904[protein domain specific binding] GO:0030014[CCR4-NOT complex] GO:0030015[CCR4-NOT core complex] GO:0030331[nuclear estrogen receptor binding] GO:0031047[gene silencing by RNA] GO:0033147[negative regulation of intracellular estrogen receptor signaling pathway] GO:0035195[miRNA-mediated gene silencing] GO:0042974[nuclear retinoic acid receptor binding] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:0060090[molecular adaptor activity] GO:0060213[positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:0061014[positive regulation of mRNA catabolic process] GO:0070016[armadillo repeat domain binding] GO:0090503[RNA phosphodiester bond hydrolysis, exonucleolytic] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:2000036[regulation of stem cell population maintenance]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
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GO:0017148[negative regulation of translation] GO:0030015[CCR4-NOT core complex]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
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GO:0017148[negative regulation of translation] GO:0030015[CCR4-NOT core complex]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
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GO:0017148[negative regulation of translation] GO:0030015[CCR4-NOT core complex]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000288[nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000289[nuclear-transcribed mRNA poly(A) tail shortening] GO:0000932[P-body] GO:0003723[RNA binding] GO:0004535[poly(A)-specific ribonuclease activity] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005778[peroxisomal membrane] GO:0005829[cytosol] GO:0006417[regulation of translation] GO:0010606[positive regulation of cytoplasmic mRNA processing body assembly] GO:0016020[membrane] GO:0017148[negative regulation of translation] GO:0019904[protein domain specific binding] GO:0030014[CCR4-NOT complex] GO:0030015[CCR4-NOT core complex] GO:0030331[nuclear estrogen receptor binding] GO:0031047[gene silencing by RNA] GO:0033147[negative regulation of intracellular estrogen receptor signaling pathway] GO:0035195[miRNA-mediated gene silencing] GO:0042974[nuclear retinoic acid receptor binding] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:0060090[molecular adaptor activity] GO:0060213[positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:0061014[positive regulation of mRNA catabolic process] GO:0070016[armadillo repeat domain binding] GO:0090503[RNA phosphodiester bond hydrolysis, exonucleolytic] GO:1900153[positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:2000036[regulation of stem cell population maintenance]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
Show all
GO:0017148[negative regulation of translation] GO:0030015[CCR4-NOT core complex]
The Human Protein Atlas project is funded
