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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q11.22
Chromosome location (bp)
35699272 - 35700984
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Antibiotic, Antimicrobial
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P60602 [Direct mapping] Reactive oxygen species modulator 1
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Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005744[TIM23 mitochondrial import inner membrane translocase complex] GO:0006886[intracellular protein transport] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0030150[protein import into mitochondrial matrix] GO:0031640[killing of cells of another organism] GO:0034614[cellular response to reactive oxygen species] GO:0042742[defense response to bacterium] GO:0045039[protein insertion into mitochondrial inner membrane] GO:0050829[defense response to Gram-negative bacterium] GO:0050830[defense response to Gram-positive bacterium] GO:0051838[cytolysis by host of symbiont cells] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0090399[replicative senescence] GO:2000379[positive regulation of reactive oxygen species metabolic process]
P60602 [Direct mapping] Reactive oxygen species modulator 1
Show all
Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005744[TIM23 mitochondrial import inner membrane translocase complex] GO:0006886[intracellular protein transport] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0030150[protein import into mitochondrial matrix] GO:0031640[killing of cells of another organism] GO:0034614[cellular response to reactive oxygen species] GO:0042742[defense response to bacterium] GO:0045039[protein insertion into mitochondrial inner membrane] GO:0050829[defense response to Gram-negative bacterium] GO:0050830[defense response to Gram-positive bacterium] GO:0051838[cytolysis by host of symbiont cells] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0090399[replicative senescence] GO:2000379[positive regulation of reactive oxygen species metabolic process]
P60602 [Direct mapping] Reactive oxygen species modulator 1
Show all
Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005744[TIM23 mitochondrial import inner membrane translocase complex] GO:0006886[intracellular protein transport] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0030150[protein import into mitochondrial matrix] GO:0031640[killing of cells of another organism] GO:0034614[cellular response to reactive oxygen species] GO:0042742[defense response to bacterium] GO:0045039[protein insertion into mitochondrial inner membrane] GO:0050829[defense response to Gram-negative bacterium] GO:0050830[defense response to Gram-positive bacterium] GO:0051838[cytolysis by host of symbiont cells] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0090399[replicative senescence] GO:2000379[positive regulation of reactive oxygen species metabolic process]
P60602 [Direct mapping] Reactive oxygen species modulator 1
Show all
Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005744[TIM23 mitochondrial import inner membrane translocase complex] GO:0006886[intracellular protein transport] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0030150[protein import into mitochondrial matrix] GO:0031640[killing of cells of another organism] GO:0034614[cellular response to reactive oxygen species] GO:0042742[defense response to bacterium] GO:0045039[protein insertion into mitochondrial inner membrane] GO:0050829[defense response to Gram-negative bacterium] GO:0050830[defense response to Gram-positive bacterium] GO:0051838[cytolysis by host of symbiont cells] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0090399[replicative senescence] GO:2000379[positive regulation of reactive oxygen species metabolic process]
P60602 [Direct mapping] Reactive oxygen species modulator 1
Show all
Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005739[mitochondrion] GO:0005743[mitochondrial inner membrane] GO:0005744[TIM23 mitochondrial import inner membrane translocase complex] GO:0006886[intracellular protein transport] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0030150[protein import into mitochondrial matrix] GO:0031640[killing of cells of another organism] GO:0034614[cellular response to reactive oxygen species] GO:0042742[defense response to bacterium] GO:0045039[protein insertion into mitochondrial inner membrane] GO:0050829[defense response to Gram-negative bacterium] GO:0050830[defense response to Gram-positive bacterium] GO:0051838[cytolysis by host of symbiont cells] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:0090399[replicative senescence] GO:2000379[positive regulation of reactive oxygen species metabolic process]
The Human Protein Atlas project is funded
