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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes FDA approved drug targets Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q13.1
Chromosome location (bp)
64318121 - 64321811
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Antioxidant, Oxidoreductase, Peroxidase
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001016[RNA polymerase III transcription regulatory region sequence-specific DNA binding] GO:0004601[peroxidase activity] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005777[peroxisome] GO:0005782[peroxisomal matrix] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006979[response to oxidative stress] GO:0008379[thioredoxin peroxidase activity] GO:0016209[antioxidant activity] GO:0016480[negative regulation of transcription by RNA polymerase III] GO:0016491[oxidoreductase activity] GO:0031410[cytoplasmic vesicle] GO:0034599[cellular response to oxidative stress] GO:0034614[cellular response to reactive oxygen species] GO:0042744[hydrogen peroxide catabolic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0045454[cell redox homeostasis] GO:0048471[perinuclear region of cytoplasm] GO:0070062[extracellular exosome] GO:0098869[cellular oxidant detoxification] GO:0140824[thioredoxin-dependent peroxiredoxin activity]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001016[RNA polymerase III transcription regulatory region sequence-specific DNA binding] GO:0004601[peroxidase activity] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005777[peroxisome] GO:0005782[peroxisomal matrix] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006979[response to oxidative stress] GO:0008379[thioredoxin peroxidase activity] GO:0016209[antioxidant activity] GO:0016480[negative regulation of transcription by RNA polymerase III] GO:0016491[oxidoreductase activity] GO:0031410[cytoplasmic vesicle] GO:0034599[cellular response to oxidative stress] GO:0034614[cellular response to reactive oxygen species] GO:0042744[hydrogen peroxide catabolic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0045454[cell redox homeostasis] GO:0048471[perinuclear region of cytoplasm] GO:0070062[extracellular exosome] GO:0098869[cellular oxidant detoxification] GO:0140824[thioredoxin-dependent peroxiredoxin activity]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001016[RNA polymerase III transcription regulatory region sequence-specific DNA binding] GO:0004601[peroxidase activity] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005777[peroxisome] GO:0005782[peroxisomal matrix] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0006979[response to oxidative stress] GO:0008379[thioredoxin peroxidase activity] GO:0016209[antioxidant activity] GO:0016480[negative regulation of transcription by RNA polymerase III] GO:0016491[oxidoreductase activity] GO:0031410[cytoplasmic vesicle] GO:0034599[cellular response to oxidative stress] GO:0034614[cellular response to reactive oxygen species] GO:0042744[hydrogen peroxide catabolic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0045454[cell redox homeostasis] GO:0048471[perinuclear region of cytoplasm] GO:0070062[extracellular exosome] GO:0098869[cellular oxidant detoxification] GO:0140824[thioredoxin-dependent peroxiredoxin activity]
The Human Protein Atlas project is funded
