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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.2
Chromosome location (bp)
10960932 - 11079426
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
A7E2E1 [Target identity:100%; Query identity:100%] SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_a; cDNA FLJ77531, highly similar to Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), mRNA
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
A7E2E1 [Target identity:100%; Query identity:100%] SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_a; cDNA FLJ77531, highly similar to Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), mRNA
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
Q9HBD4 [Direct mapping] SMARCA4 isoform 2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_c; Transcription activator BRG1
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000776[kinetochore] GO:0000785[chromatin] GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001221[transcription coregulator binding] GO:0001650[fibrillar center] GO:0002039[p53 binding] GO:0003407[neural retina development] GO:0003677[DNA binding] GO:0003713[transcription coactivator activity] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0004386[helicase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006325[chromatin organization] GO:0006337[nucleosome disassembly] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007399[nervous system development] GO:0008094[ATP-dependent activity, acting on DNA] GO:0008284[positive regulation of cell population proliferation] GO:0016020[membrane] GO:0016363[nuclear matrix] GO:0016514[SWI/SNF complex] GO:0016586[RSC-type complex] GO:0016787[hydrolase activity] GO:0016887[ATP hydrolysis activity] GO:0030071[regulation of mitotic metaphase/anaphase transition] GO:0030177[positive regulation of Wnt signaling pathway] GO:0030308[negative regulation of cell growth] GO:0030957[Tat protein binding] GO:0031492[nucleosomal DNA binding] GO:0032991[protein-containing complex] GO:0042393[histone binding] GO:0043923[positive regulation by host of viral transcription] GO:0045582[positive regulation of T cell differentiation] GO:0045596[negative regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0047485[protein N-terminus binding] GO:0050681[nuclear androgen receptor binding] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070182[DNA polymerase binding] GO:0070316[regulation of G0 to G1 transition] GO:0070577[lysine-acetylated histone binding] GO:0070603[SWI/SNF superfamily-type complex] GO:0071564[npBAF complex] GO:0071565[nBAF complex] GO:0140092[bBAF complex] GO:0140288[GBAF complex] GO:0140658[ATP-dependent chromatin remodeler activity] GO:1901838[positive regulation of transcription of nucleolar large rRNA by RNA polymerase I] GO:1902459[positive regulation of stem cell population maintenance] GO:1902661[positive regulation of glucose mediated signaling pathway] GO:1902895[positive regulation of miRNA transcription] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000781[positive regulation of double-strand break repair] GO:2000819[regulation of nucleotide-excision repair]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Other congenital malformations Other diseases Mental and behavioural disorders Others Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
