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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.3
Chromosome location (bp)
4815932 - 4831712
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis 1,2,3,4. Ligand binding to these receptors results in TRIF recruitment through its TIR domain 5,6,7. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively 8,9,10. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens 11. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q8IUC6 [Direct mapping] TIR domain-containing adapter molecule 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002281[macrophage activation involved in immune response] GO:0002376[immune system process] GO:0002735[positive regulation of myeloid dendritic cell cytokine production] GO:0002756[MyD88-independent toll-like receptor signaling pathway] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005776[autophagosome] GO:0005829[cytosol] GO:0006809[nitric oxide biosynthetic process] GO:0006915[apoptotic process] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0010008[endosome membrane] GO:0010508[positive regulation of autophagy] GO:0010628[positive regulation of gene expression] GO:0019901[protein kinase binding] GO:0030890[positive regulation of B cell proliferation] GO:0031398[positive regulation of protein ubiquitination] GO:0031410[cytoplasmic vesicle] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0032092[positive regulation of protein binding] GO:0032481[positive regulation of type I interferon production] GO:0032496[response to lipopolysaccharide] GO:0032722[positive regulation of chemokine production] GO:0032728[positive regulation of interferon-beta production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032816[positive regulation of natural killer cell activation] GO:0035666[TRIF-dependent toll-like receptor signaling pathway] GO:0042100[B cell proliferation] GO:0042113[B cell activation] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043254[regulation of protein-containing complex assembly] GO:0043330[response to exogenous dsRNA] GO:0045087[innate immune response] GO:0045429[positive regulation of nitric oxide biosynthetic process] GO:0050871[positive regulation of B cell activation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051607[defense response to virus] GO:0060907[positive regulation of macrophage cytokine production] GO:0071222[cellular response to lipopolysaccharide] GO:0097190[apoptotic signaling pathway] GO:0097342[ripoptosome] GO:0140052[cellular response to oxidised low-density lipoprotein particle stimulus] GO:1900017[positive regulation of cytokine production involved in inflammatory response]
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