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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q11.23
Chromosome location (bp)
38346482 - 38377013
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria 1,2. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide 3,4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Antibiotic, Antimicrobial
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity, Innate immunity, Lipid transport, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P18428 [Direct mapping] Lipopolysaccharide-binding protein
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Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001530[lipopolysaccharide binding] GO:0002232[leukocyte chemotaxis involved in inflammatory response] GO:0002281[macrophage activation involved in immune response] GO:0002376[immune system process] GO:0002752[cell surface pattern recognition receptor signaling pathway] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006869[lipid transport] GO:0006953[acute-phase response] GO:0006968[cellular defense response] GO:0008228[opsonization] GO:0008289[lipid binding] GO:0009986[cell surface] GO:0015026[coreceptor activity] GO:0015920[lipopolysaccharide transport] GO:0016020[membrane] GO:0030593[neutrophil chemotaxis] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0032490[detection of molecule of bacterial origin] GO:0032496[response to lipopolysaccharide] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032722[positive regulation of chemokine production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0034145[positive regulation of toll-like receptor 4 signaling pathway] GO:0042742[defense response to bacterium] GO:0043032[positive regulation of macrophage activation] GO:0045087[innate immune response] GO:0050829[defense response to Gram-negative bacterium] GO:0050830[defense response to Gram-positive bacterium] GO:0060265[positive regulation of respiratory burst involved in inflammatory response] GO:0070062[extracellular exosome] GO:0070891[lipoteichoic acid binding] GO:0071222[cellular response to lipopolysaccharide] GO:0071223[cellular response to lipoteichoic acid] GO:0071723[lipopeptide binding] GO:0090023[positive regulation of neutrophil chemotaxis]
The Human Protein Atlas project is funded
