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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q22.3
Chromosome location (bp)
55124110 - 55145423
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
IgE-binding protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Lectin
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001772[immunological synapse] GO:0002376[immune system process] GO:0002548[monocyte chemotaxis] GO:0003723[RNA binding] GO:0004864[protein phosphatase inhibitor activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005681[spliceosomal complex] GO:0005737[cytoplasm] GO:0005743[mitochondrial inner membrane] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006397[mRNA processing] GO:0008380[RNA splicing] GO:0009986[cell surface] GO:0016020[membrane] GO:0019863[IgE binding] GO:0019903[protein phosphatase binding] GO:0030154[cell differentiation] GO:0030246[carbohydrate binding] GO:0030593[neutrophil chemotaxis] GO:0030667[secretory granule membrane] GO:0030855[epithelial cell differentiation] GO:0031334[positive regulation of protein-containing complex assembly] GO:0042056[chemoattractant activity] GO:0042129[regulation of T cell proliferation] GO:0043236[laminin binding] GO:0045087[innate immune response] GO:0045806[negative regulation of endocytosis] GO:0048245[eosinophil chemotaxis] GO:0048246[macrophage chemotaxis] GO:0050860[negative regulation of T cell receptor signaling pathway] GO:0050918[positive chemotaxis] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0070232[regulation of T cell apoptotic process] GO:0071674[mononuclear cell migration] GO:0071677[positive regulation of mononuclear cell migration] GO:0090280[positive regulation of calcium ion import] GO:0101003[ficolin-1-rich granule membrane] GO:0140693[molecular condensate scaffold activity] GO:1902041[regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903614[negative regulation of protein tyrosine phosphatase activity] GO:2000521[negative regulation of immunological synapse formation] GO:2001189[negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
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