Blood protein - LYVE1 - The Human Protein Atlas

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LYVE1

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Field

Cluster

Cluster

Cluster

Pathway

SUMMARY

TISSUE

BRAIN

SINGLE CELL

TISSUE CELL

PATHOLOGY

DISEASE

IMMUNE

BLOOD

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CELL LINE

STRUCTURE

INTERACTION

LYVE1

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LYVE1
Gene descriptionⁱ Full gene name according to HGNC.	Lymphatic vessel endothelial hyaluronan receptor 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane

HUMAN PROTEIN ATLAS INFORMATION
Blood-based immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search.	Not analysed since only proteins predicted to be actively secreted to blood is analysed here
Mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	Detected
Proximity extension assayⁱ Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years.	Not detected

PROTEIN CONCENTRATION IN BLOOD - IMMUNOASSAYⁱ

Protein target not predicted to be actively secreted to blood and therefore not analyzed here

PROTEIN CONCENTRATION IN PLASMA - MASS SPECTROMETRYⁱ The protein concentration in blood is quantified by mass spectrometry-based plasma proteomics and estimated from spectral counts in a publicly available data set obtained from the PeptideAtlas.
Detected in plasma by mass spectrometry 3.3 mg/L, PeptideAtlas

PROTEIN DETECTED IN PLASMA - PROXIMITY EXTENSION ASSAYⁱ The protein profiling results based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Protein expression levels are reported as Normalized Protein eXpression (NPX).
Pending analysis

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.

contact@proteinatlas.org