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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Glial cells:
Not detected
Neuronal cells:
Not detected
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
15.5
nTPM
HPA Brain:
15.5
nTPM
GTEx:
15.5
nTPM
FANTOM5:
14.2
Scaled Tags Per Million
Pig:
230.3
nTPM
Mouse:
17.9
nTPM
HIPPOCAMPUS - Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Antibody HPA054891
Antibody HPA057272
Glial cells
Not detected
Not detected
Neuronal cells
Not detected
Medium
HIPPOCAMPAL FORMATION - HPA Brain RNA-seq
Max nTPM
15.5
Sample id
Sample description
nTPM
Hippocampus nTPM: 14.1
2148
Female, age 91, left hemisphere
15.6
1911
Female, age 85, right hemisphere
15.1
1898
Male, age 80, left hemisphere
13.7
1855
Male, age 76, left hemisphere
13.6
2621
Female, age 67, right hemisphere
13.4
2529
Female, age 94, left hemisphere
13.2
Dentate gyrus nTPM: 14.1
1927
Female, age 91, both hemispheres
18.4
2531
Female, age 67, both hemispheres
15.7
2246
Female, age 85, both hemispheres
14.9
2528
Male, age 74, both hemispheres
13.8
2530
Female, age 94, left hemisphere
11.1
2010
Male, age 76, both hemispheres
10.7
Entorhinal gyrus nTPM: 14.7
1938
Female, age 85, left hemisphere
17.4
2686
Male, age 75, right hemisphere
17.4
2613
Female, age 94, left hemisphere
17.3
1787
Male, age 76, left hemisphere
13.4
2117
Female, age 91, right hemisphere
11.7
2764
Male, age 80, right hemisphere
11.1
Hippocampus, CA1 nTPM: 14.5
1873
Female, age 85, both hemispheres
16.2
2527
Male, age 74, both hemispheres
14.9
2082
Female, age 91, right hemisphere
14.2
2749
Male, age 80, left hemisphere
13.7
2045
Male, age 76, both hemispheres
13.3
Hippocampus, CA2 nTPM: 13.5
1963
Male, age 80, left hemisphere
17.3
2113
Female, age 91, right hemisphere
14.8
1892
Male, age 76, both hemispheres
13.7
2249
Male, age 74, both hemispheres
12.1
1940
Female, age 85, left hemisphere
11.9
2437
Female, age 94, left hemisphere
11.2
Hippocampus, CA3 nTPM: 14.5
2861
Female, age 67, both hemispheres
16.6
2137
Male, age 80, left hemisphere
16.2
2620
Female, age 94, left hemisphere
16.1
1891
Female, age 85, both hemispheres
14.0
2436
Male, age 74, both hemispheres
12.2
1867
Male, age 76, both hemispheres
12.0
Parahippocampal cortex nTPM: 15.2
2693
Female, age 94, both hemispheres
17.5
2622
Female, age 67, right hemisphere
16.6
2245
Female, age 91, both hemispheres
16.2
2250
Female, age 67, right hemisphere
16.1
2692
Male, age 74, both hemispheres
15.9
1850
Male, age 80, both hemispheres
15.8
1933
Female, age 85, both hemispheres
15.8
1990
Female, age 91, right hemisphere
13.8
2532
Female, age 72, left hemisphere
13.1
2018
Male, age 76, both hemispheres
11.6
Perirhinal gyrus nTPM: 15.5
1847
Female, age 91, left hemisphere
17.2
1841
Female, age 85, right hemisphere
16.7
2848
Male, age 76, right hemisphere
16.6
2521
Female, age 94, right hemisphere
13.6
1794
Male, age 80, right hemisphere
13.5
Subiculum nTPM: 12.0
2729
Female, age 91, right hemisphere
14.7
1977
Female, age 85, both hemispheres
13.5
2438
Female, age 94, left hemisphere
12.7
2619
Male, age 74, both hemispheres
12.5
1901
Male, age 80, both hemispheres
10.2
2042
Male, age 76, both hemispheres
8.4
HIPPOCAMPAL FORMATION - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Average nTPM
15.5
GTEx sample id
Sample description
nTPM
Brain - Hippocampus Average nTPM: 15.5
Samples: 197
Max nTPM: 53.0
Min nTPM: 3.7
Std nTPM: 7.6
Median nTPM: 13.7
GTEX-1HT8W-0011-R1b-SM-CJI3V
30-39 years, male
53.0
GTEX-11DXW-0011-R1a-SM-DNZZD
40-49 years, male
42.0
GTEX-QDT8-0011-R1A-SM-32PKS
30-39 years, female
39.1
GTEX-13FLW-0011-R1b-SM-5LZX2
50-59 years, male
35.8
GTEX-1J1OQ-0011-R1a-SM-A9G1Z
40-49 years, female
35.2
GTEX-T5JC-0011-R1A-SM-32PM6
20-29 years, male
34.6
GTEX-16YQH-0011-R1a-SM-7LT8R
30-39 years, male
34.5
GTEX-145MH-0011-R1b-SM-5PNWY
50-59 years, male
31.9
GTEX-1B8L1-0011-R1a-SM-7P8SS
60-69 years, male
30.5
GTEX-1GZ2Q-0011-R1a-SM-CJI2Y
40-49 years, male
30.0
GTEX-RNOR-0011-R1A-SM-CNNP5
50-59 years, female
29.9
GTEX-R55E-0011-R1A-SM-2TC6N
20-29 years, male
29.2
GTEX-131XH-0011-R1a-SM-5DUWA
50-59 years, male
28.5
GTEX-QVJO-0011-R1A-SM-2S1QI
60-69 years, female
28.2
GTEX-WL46-0011-R1A-SM-3LK6M
50-59 years, male
28.0
GTEX-1GMR8-0011-R1b-SM-CJI2O
50-59 years, female
27.9
GTEX-14C5O-0011-R1b-SM-6AJBW
60-69 years, male
26.4
GTEX-132Q8-0011-R1a-SM-5EGLK
60-69 years, male
26.1
GTEX-ZAB4-0011-R1a-SM-4RGNO
40-49 years, male
25.9
GTEX-WWYW-0011-R1A-SM-3TW8G
50-59 years, female
25.8
GTEX-P44G-0011-R1A-SM-2I3FE
30-39 years, male
25.6
GTEX-1ICLZ-0011-R1b-SM-A9SM3
60-69 years, male
25.5
GTEX-14ABY-0011-R1a-SM-6EU2W
50-59 years, male
24.9
GTEX-1F75A-0011-R1b-SM-CE6RA
50-59 years, male
24.9
GTEX-12ZZX-0011-R1a-SM-5EQ6B
40-49 years, female
24.7
GTEX-1IKK5-0011-R1b-SM-CE6SQ
60-69 years, male
24.7
GTEX-1LG7Y-0011-R1a-SM-EYYWV
50-59 years, male
24.5
GTEX-WVLH-0011-R1A-SM-4MVOK
50-59 years, male
24.1
GTEX-13OW6-0011-R1a-SM-5L3HQ
50-59 years, male
23.9
GTEX-Y8DK-0011-R1A-SM-4RGLO
60-69 years, male
23.9
GTEX-13O3Q-0011-R1b-SM-5KM3L
50-59 years, male
22.7
GTEX-14PN4-0011-R1b-SM-69LP8
50-59 years, male
22.0
GTEX-17JCI-0011-R1b-SM-718A3
60-69 years, female
21.9
GTEX-13FHO-0011-R1b-SM-5KLZG
60-69 years, male
21.4
GTEX-ZDXO-0011-R1a-SM-4WKF4
60-69 years, male
21.4
GTEX-NPJ7-0011-R1a-SM-3GACT
60-69 years, female
21.3
GTEX-1IY9M-0011-R1a-SM-EXURZ
60-69 years, male
21.2
GTEX-17F97-0011-R1b-SM-7IGM9
50-59 years, male
20.6
GTEX-1I1HK-0011-R1b-SM-CM2T7
60-69 years, male
20.6
GTEX-13PDP-0011-R1a-SM-5PNX5
60-69 years, male
20.3
GTEX-QMR6-0011-R1A-SM-32PKW
50-59 years, male
20.1
GTEX-S7SE-0011-R1A-SM-2XCDE
50-59 years, male
20.0
GTEX-1F6IF-0011-R1b-SM-9WG78
60-69 years, male
20.0
GTEX-14JIY-0011-R1a-SM-68713
60-69 years, male
19.9
GTEX-12WSE-0011-R1b-SM-5GU4V
20-29 years, male
19.6
GTEX-NL3H-0011-R1a-SM-48TDJ
60-69 years, male
19.6
GTEX-YFC4-0011-R1a-SM-4V6EH
40-49 years, female
19.4
GTEX-11GSP-0011-R1a-SM-9QEJ3
60-69 years, female
19.2
GTEX-1EMGI-0011-R1b-SM-9OSWZ
60-69 years, male
18.9
GTEX-14BIM-0011-R1a-SM-69LQI
60-69 years, female
18.6
GTEX-PWO3-0011-R1A-SM-2I5EW
60-69 years, female
18.4
GTEX-X585-0011-R1B-SM-46MVE
50-59 years, male
18.4
GTEX-1H1ZS-0011-R1b-SM-A9G1E
70-79 years, male
18.3
GTEX-1H3VE-0011-R1a-SM-A9G1K
40-49 years, male
17.9
GTEX-PVOW-0011-R1A-SM-32PL6
40-49 years, male
17.5
GTEX-1A3MX-0011-R1b-SM-7P8PH
60-69 years, male
17.5
GTEX-1313W-0011-R1b-SM-5EQ4A
50-59 years, female
17.3
GTEX-13NYB-0011-R1b-SM-5KM4F
40-49 years, male
17.3
GTEX-14LLW-0011-R1a-SM-5ZZVD
70-79 years, female
17.1
GTEX-11EI6-0011-R1a-SM-DO93L
60-69 years, male
17.1
GTEX-131YS-0011-R1a-SM-5DUXC
60-69 years, female
17.0
GTEX-139TT-0011-R1a-SM-5LZVD
60-69 years, male
17.0
GTEX-P44H-0011-R1A-SM-3NM8J
40-49 years, male
16.9
GTEX-WHSE-0011-R1A-SM-3P5ZK
20-29 years, male
16.8
GTEX-ZUA1-0011-R1a-SM-4YCE2
40-49 years, male
16.6
GTEX-TSE9-0011-R1A-SM-3DB7E
60-69 years, female
16.5
GTEX-X4XX-0011-R1B-SM-3P622
60-69 years, male
16.5
GTEX-QVUS-0011-R1A-SM-3GAD2
60-69 years, female
16.3
GTEX-13N2G-0011-R1b-SM-5MR3G
60-69 years, male
16.1
GTEX-1F48J-0011-R1a-SM-9QEIC
50-59 years, female
16.1
GTEX-1IDJH-0011-R1b-SM-ARU6U
70-79 years, male
16.0
GTEX-14ASI-0011-R1b-SM-5S2TY
60-69 years, male
15.9
GTEX-WZTO-0011-R1B-SM-3NMAR
40-49 years, male
15.9
GTEX-13O3O-0011-R1b-SM-5KM2K
60-69 years, female
15.7
GTEX-1HSMO-0011-R1a-SM-CM2SV
60-69 years, male
15.7
GTEX-17HG3-0011-R1a-SM-7LG6H
30-39 years, female
15.6
GTEX-144GO-0011-R1a-SM-5PNWO
60-69 years, male
15.5
GTEX-YJ89-0011-R1a-SM-4RGLS
60-69 years, male
15.5
GTEX-144GL-0011-R1a-SM-5PNZ5
50-59 years, male
15.4
GTEX-Q2AG-0011-R1A-SM-2HMJI
40-49 years, female
15.4
GTEX-13SLW-0011-R1a-SM-5S2W7
70-79 years, male
15.3
GTEX-139T8-0011-R1a-SM-5HL75
60-69 years, male
15.2
GTEX-145LU-0011-R1a-SM-5Q5CE
50-59 years, male
15.2
GTEX-13FHP-0011-R1b-SM-5K7XL
50-59 years, male
15.1
GTEX-1H3NZ-0011-R1a-SM-CKZP5
60-69 years, male
15.1
GTEX-1B933-0011-R1b-SM-9QEGW
50-59 years, female
15.0
GTEX-N7MT-0011-R1a-SM-CNPO1
60-69 years, female
15.0
GTEX-11ONC-0011-R1a-SM-57WD4
60-69 years, male
14.9
GTEX-13OVJ-0011-R1b-SM-5L3I6
50-59 years, female
14.5
GTEX-13OW7-0011-R1b-SM-5L3HF
50-59 years, male
14.5
GTEX-ZF28-0011-R1a-SM-4WWD1
60-69 years, male
14.4
GTEX-11GS4-0011-R1a-SM-DO129
60-69 years, male
14.4
GTEX-12WSD-0011-R1b-SM-5LZVY
60-69 years, female
14.1
GTEX-12WSF-0011-R1a-SM-5DUVI
70-79 years, male
13.8
GTEX-16Z82-0011-R1b-SM-7EPHZ
60-69 years, male
13.7
GTEX-ZE7O-0011-R1a-SM-57WDM
50-59 years, female
13.7
GTEX-15CHQ-0011-R1a-SM-COH27
60-69 years, male
13.7
GTEX-1GF9W-0011-R1a-SM-9QEIQ
60-69 years, male
13.7
GTEX-1GTWX-0011-R1a-SM-CE6RL
60-69 years, male
13.7
GTEX-1H3O1-0011-R1b-SM-CL554
60-69 years, male
13.7
GTEX-1I1GQ-0011-R1a-SM-CY8GG
50-59 years, male
13.5
GTEX-N7MS-0011-R1a-SM-2HMJG
60-69 years, male
13.4
GTEX-1CB4G-0011-R1b-SM-9QEHT
60-69 years, male
13.4
GTEX-1I1GS-0011-R1a-SM-CJI43
60-69 years, male
13.3
GTEX-1J8Q2-0011-R1a-SM-D4P2D
60-69 years, male
13.3
GTEX-14PJM-0011-R1a-SM-CNPO3
50-59 years, female
13.1
GTEX-1EX96-0011-R1a-SM-CE6R5
50-59 years, male
13.1
GTEX-13X6I-0011-R1b-SM-5PNZC
60-69 years, male
13.0
GTEX-1F75W-0011-R1a-SM-ARU81
60-69 years, male
13.0
GTEX-12WSH-0011-R1a-SM-5GU5V
50-59 years, male
12.9
GTEX-13FTY-0011-R1a-SM-5LZXE
40-49 years, female
12.9
GTEX-13JUV-0011-R1a-SM-5LZY4
40-49 years, female
12.9
GTEX-13NYS-0011-R1b-SM-5MR55
60-69 years, male
12.9
GTEX-1399T-0011-R1b-SM-5DUWN
60-69 years, male
12.8
GTEX-13CF2-0011-R1a-SM-5LZY1
60-69 years, male
12.7
GTEX-1IOXB-0011-R1a-SM-D4P27
50-59 years, male
12.6
GTEX-14PQA-0011-R1b-SM-6EU1G
50-59 years, female
12.4
GTEX-15ER7-0011-R1b-SM-7KUE1
20-29 years, female
12.4
GTEX-T6MN-0011-R1A-SM-32QOY
50-59 years, male
12.3
GTEX-13G51-0011-R1a-SM-5LZYR
60-69 years, male
12.2
GTEX-11UD1-0011-R1b-SM-5BC7D
40-49 years, female
12.1
GTEX-1CAV2-0011-R1a-SM-ARZML
40-49 years, female
12.1
GTEX-1GF9V-0011-R1a-SM-CKZNQ
60-69 years, male
12.1
GTEX-1HGF4-0011-R1a-SM-CJI3S
60-69 years, male
12.1
GTEX-13OW8-0011-R1a-SM-5L3HI
60-69 years, male
12.0
GTEX-1HBPI-0011-R1b-SM-A9SKF
50-59 years, male
12.0
GTEX-11ZVC-0011-R1b-SM-5BC6M
50-59 years, female
11.9
GTEX-1EWIQ-0011-R1a-SM-9OSX7
70-79 years, female
11.9
GTEX-1H1DG-0011-R1b-SM-CKZP1
70-79 years, male
11.9
GTEX-145LS-0011-R1b-SM-5PNUP
60-69 years, female
11.8
GTEX-14E7W-0011-R1b-SM-5YYAT
70-79 years, male
11.8
GTEX-1C6VR-0011-R1a-SM-7MXUE
60-69 years, male
11.8
GTEX-1GN1U-0011-R1a-SM-CJI25
50-59 years, female
11.8
GTEX-ZVZQ-0011-R1a-SM-57WBU
60-69 years, female
11.7
GTEX-1AX9I-0011-R1b-SM-7RHG2
60-69 years, male
11.7
GTEX-14E6D-0011-R1b-SM-5YYAW
50-59 years, male
11.6
GTEX-11GSO-0011-R1b-SM-57WD3
60-69 years, male
11.5
GTEX-1HR98-0011-R1a-SM-ARZLQ
60-69 years, male
11.5
GTEX-1F6I4-0011-R1a-SM-9OSWU
60-69 years, male
11.3
GTEX-1H1CY-0011-R1a-SM-CKZOZ
60-69 years, female
11.3
GTEX-13112-0011-R1b-SM-5HL7K
50-59 years, male
11.1
GTEX-1E1VI-0011-R1a-SM-ARZMM
50-59 years, male
10.8
GTEX-1I1GV-0011-R1a-SM-CL559
60-69 years, male
10.8
GTEX-13FXS-0011-R1a-SM-5K7U6
50-59 years, male
10.7
GTEX-15DCD-0011-R1b-SM-6LPIJ
70-79 years, female
10.6
GTEX-1EH9U-0011-R1b-SM-CJI2B
60-69 years, male
10.5
GTEX-1212Z-0011-R1b-SM-5BC72
60-69 years, male
10.4
GTEX-14PJO-0011-R1b-SM-6AJAK
60-69 years, male
10.3
GTEX-16XZZ-0011-R1a-SM-7LTAH
60-69 years, male
10.3
GTEX-1GN73-0011-R1a-SM-CKZNT
60-69 years, male
10.3
GTEX-12WSM-0011-R1a-SM-5LZW6
60-69 years, male
10.2
GTEX-1B8SF-0011-R1b-SM-7P8Q8
60-69 years, male
10.2
GTEX-1BAJH-0011-R1a-SM-7P8SV
70-79 years, male
10.2
GTEX-1EKGG-0011-R1b-SM-9QEI1
60-69 years, male
10.2
GTEX-17EVQ-0011-R1a-SM-7189S
70-79 years, male
10.1
GTEX-UTHO-0011-R1A-SM-3GIJO
60-69 years, male
10.1
GTEX-1C64N-0011-R1b-SM-7P8Q7
50-59 years, male
10.1
GTEX-16NPV-0011-R1b-SM-7MGVZ
50-59 years, female
10.0
GTEX-NPJ8-0011-R1a-SM-33HCB
40-49 years, male
9.8
GTEX-XMD1-0011-R1A-SM-4AT4C
60-69 years, male
9.8
GTEX-1A8G6-0011-R1a-SM-7P8PC
60-69 years, male
9.8
GTEX-13RTJ-0011-R1a-SM-5O9D9
60-69 years, male
9.6
GTEX-1HSKV-0011-R1b-SM-CMKH7
60-69 years, male
9.4
GTEX-11ZTS-0011-R1a-SM-5BC71
60-69 years, female
9.3
GTEX-11WQC-0011-R1b-SM-DO932
60-69 years, male
9.0
GTEX-13JVG-0011-R1a-SM-5KM32
60-69 years, male
8.9
GTEX-13OVL-0011-R1a-SM-5L3H5
50-59 years, male
8.9
GTEX-17HII-0011-R1b-SM-7MGVW
50-59 years, male
8.8
GTEX-1B996-0011-R1b-SM-7P8PO
60-69 years, male
8.4
GTEX-17HHY-0011-R1a-SM-7189V
50-59 years, male
8.3
GTEX-17MF6-0011-R1a-SM-72D6O
40-49 years, male
8.1
GTEX-1H4P4-0011-R1b-SM-CL54V
50-59 years, male
8.0
GTEX-13N1W-0011-R1b-SM-5MR4T
70-79 years, male
7.9
GTEX-16GPK-0011-R1b-SM-7EWDH
60-69 years, male
7.8
GTEX-17EVP-0011-R1a-SM-7DHLA
40-49 years, male
7.6
GTEX-1A32A-0011-R1a-SM-7P8SQ
50-59 years, female
7.5
GTEX-13S7M-0011-R1b-SM-5PNZE
60-69 years, female
7.4
GTEX-1LB8K-0011-R1b-SM-EZ6MV
50-59 years, male
7.4
GTEX-11TUW-0011-R1a-SM-DO92S
60-69 years, male
7.3
GTEX-1GN2E-0011-R1b-SM-CE6RJ
60-69 years, male
7.2
GTEX-13QJC-0011-R1b-SM-5S2UU
60-69 years, female
7.0
GTEX-183WM-0011-R1a-SM-718A8
70-79 years, female
7.0
GTEX-13RTL-0011-R1a-SM-5PNZ8
40-49 years, male
6.9
GTEX-15UF6-0011-R1a-SM-9QEGH
70-79 years, female
6.9
GTEX-OHPN-0011-R1A-SM-2I5GB
60-69 years, female
6.7
GTEX-13NZA-0011-R1b-SM-5LUAF
60-69 years, male
6.6
GTEX-1C6VQ-0011-R1a-SM-7P8Q2
50-59 years, male
6.5
GTEX-1E2YA-0011-R1b-SM-CJI29
50-59 years, male
6.3
GTEX-14LZ3-0011-R1a-SM-69LP5
60-69 years, female
6.0
GTEX-13OW5-0011-R1b-SM-5L3GE
60-69 years, male
5.7
GTEX-13NZ8-0011-R1b-SM-5KM3V
60-69 years, female
5.5
GTEX-13QIC-0011-R1a-SM-5O9CJ
60-69 years, female
5.5
GTEX-1GZHY-0011-R1a-SM-CE6RR
50-59 years, female
5.4
GTEX-18A6Q-0011-R1b-SM-731DI
60-69 years, male
3.9
GTEX-X4EP-0011-R1A-SM-3P624
60-69 years, female
3.9
GTEX-1CB4J-0011-R1a-SM-9WG64
60-69 years, male
3.8
GTEX-1H23P-0011-R1a-SM-ACKVC
60-69 years, male
3.7
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HIPPOCAMPAL FORMATION - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.