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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q36.1
Chromosome location (bp)
223975045 - 224039318
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation, Neurogenesis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
A0A024R451 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_a
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SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004867[serine-type endopeptidase inhibitor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005539[glycosaminoglycan binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005829[cytosol] GO:0007399[nervous system development] GO:0008201[heparin binding] GO:0010466[negative regulation of peptidase activity] GO:0010757[negative regulation of plasminogen activation] GO:0010951[negative regulation of endopeptidase activity] GO:0010955[negative regulation of protein processing] GO:0030154[cell differentiation] GO:0030195[negative regulation of blood coagulation] GO:0030334[regulation of cell migration] GO:0030414[peptidase inhibitor activity] GO:0031091[platelet alpha granule] GO:0031232[extrinsic component of external side of plasma membrane] GO:0031594[neuromuscular junction] GO:0045861[negative regulation of proteolysis] GO:0048711[positive regulation of astrocyte differentiation] GO:0062023[collagen-containing extracellular matrix] GO:0090331[negative regulation of platelet aggregation] GO:1903561[extracellular vesicle]
A0A024R498 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_b
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SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004867[serine-type endopeptidase inhibitor activity] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005539[glycosaminoglycan binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005829[cytosol] GO:0007399[nervous system development] GO:0007596[blood coagulation] GO:0008201[heparin binding] GO:0008285[negative regulation of cell population proliferation] GO:0009611[response to wounding] GO:0010466[negative regulation of peptidase activity] GO:0010544[negative regulation of platelet activation] GO:0010757[negative regulation of plasminogen activation] GO:0010766[negative regulation of sodium ion transport] GO:0010951[negative regulation of endopeptidase activity] GO:0010955[negative regulation of protein processing] GO:0014067[negative regulation of phosphatidylinositol 3-kinase signaling] GO:0021683[cerebellar granular layer morphogenesis] GO:0030154[cell differentiation] GO:0030163[protein catabolic process] GO:0030168[platelet activation] GO:0030195[negative regulation of blood coagulation] GO:0030308[negative regulation of cell growth] GO:0030334[regulation of cell migration] GO:0030414[peptidase inhibitor activity] GO:0031091[platelet alpha granule] GO:0031232[extrinsic component of external side of plasma membrane] GO:0031594[neuromuscular junction] GO:0032940[secretion by cell] GO:0033363[secretory granule organization] GO:0042177[negative regulation of protein catabolic process] GO:0042628[mating plug formation] GO:0045861[negative regulation of proteolysis] GO:0045879[negative regulation of smoothened signaling pathway] GO:0048505[regulation of timing of cell differentiation] GO:0048711[positive regulation of astrocyte differentiation] GO:0050974[detection of mechanical stimulus involved in sensory perception] GO:0051966[regulation of synaptic transmission, glutamatergic] GO:0060291[long-term synaptic potentiation] GO:0060384[innervation] GO:0061108[seminal vesicle epithelium development] GO:0062023[collagen-containing extracellular matrix] GO:0090331[negative regulation of platelet aggregation] GO:1903561[extracellular vesicle]
The Human Protein Atlas project is funded
