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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q37.1
Chromosome location (bp)
230712842 - 230821075
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction; peptidyl-serine phosphorylation; and positive regulation of protein phosphorylation. Located in extracellular exosome. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and pancreatic cancer. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007165[signal transduction] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0014823[response to activity] GO:0016020[membrane] GO:0018105[peptidyl-serine phosphorylation] GO:0019900[kinase binding] GO:0030018[Z disc] GO:0030295[protein kinase activator activity] GO:0032147[activation of protein kinase activity] GO:0032991[protein-containing complex] GO:0034774[secretory granule lumen] GO:0035556[intracellular signal transduction] GO:0043539[protein serine/threonine kinase activator activity] GO:0070062[extracellular exosome] GO:0071476[cellular hypotonic response] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0097066[response to thyroid hormone] GO:1901017[negative regulation of potassium ion transmembrane transporter activity] GO:1901380[negative regulation of potassium ion transmembrane transport] GO:1902554[serine/threonine protein kinase complex] GO:1904813[ficolin-1-rich granule lumen]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007165[signal transduction] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0018105[peptidyl-serine phosphorylation] GO:0019900[kinase binding] GO:0030295[protein kinase activator activity] GO:0032147[activation of protein kinase activity] GO:0034774[secretory granule lumen] GO:0035556[intracellular signal transduction] GO:0043539[protein serine/threonine kinase activator activity] GO:0070062[extracellular exosome] GO:0071476[cellular hypotonic response] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:1901017[negative regulation of potassium ion transmembrane transporter activity] GO:1901380[negative regulation of potassium ion transmembrane transport] GO:1902554[serine/threonine protein kinase complex] GO:1904813[ficolin-1-rich granule lumen]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007165[signal transduction] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0018105[peptidyl-serine phosphorylation] GO:0019900[kinase binding] GO:0030295[protein kinase activator activity] GO:0032147[activation of protein kinase activity] GO:0034774[secretory granule lumen] GO:0035556[intracellular signal transduction] GO:0043539[protein serine/threonine kinase activator activity] GO:0070062[extracellular exosome] GO:0071476[cellular hypotonic response] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:1901017[negative regulation of potassium ion transmembrane transporter activity] GO:1901380[negative regulation of potassium ion transmembrane transport] GO:1902554[serine/threonine protein kinase complex] GO:1904813[ficolin-1-rich granule lumen]
The Human Protein Atlas project is funded
