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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q34.11
Chromosome location (bp)
127579370 - 127696027
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synapic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Protein transport, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P61764 [Direct mapping] Syntaxin-binding protein 1
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Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000149[SNARE binding] GO:0002576[platelet degranulation] GO:0003006[developmental process involved in reproduction] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006886[intracellular protein transport] GO:0006887[exocytosis] GO:0006904[vesicle docking involved in exocytosis] GO:0007269[neurotransmitter secretion] GO:0007274[neuromuscular synaptic transmission] GO:0007412[axon target recognition] GO:0010807[regulation of synaptic vesicle priming] GO:0015031[protein transport] GO:0016020[membrane] GO:0016082[synaptic vesicle priming] GO:0016188[synaptic vesicle maturation] GO:0016192[vesicle-mediated transport] GO:0017075[syntaxin-1 binding] GO:0019901[protein kinase binding] GO:0019904[protein domain specific binding] GO:0019905[syntaxin binding] GO:0030141[secretory granule] GO:0030424[axon] GO:0031091[platelet alpha granule] GO:0031333[negative regulation of protein-containing complex assembly] GO:0031338[regulation of vesicle fusion] GO:0031630[regulation of synaptic vesicle fusion to presynaptic active zone membrane] GO:0032229[negative regulation of synaptic transmission, GABAergic] GO:0032355[response to estradiol] GO:0032991[protein-containing complex] GO:0035493[SNARE complex assembly] GO:0035542[regulation of SNARE complex assembly] GO:0042802[identical protein binding] GO:0043274[phospholipase binding] GO:0043306[positive regulation of mast cell degranulation] GO:0043524[negative regulation of neuron apoptotic process] GO:0045335[phagocytic vesicle] GO:0045921[positive regulation of exocytosis] GO:0045956[positive regulation of calcium ion-dependent exocytosis] GO:0047485[protein N-terminus binding] GO:0048471[perinuclear region of cytoplasm] GO:0048787[presynaptic active zone membrane] GO:0050821[protein stabilization] GO:0051402[neuron apoptotic process] GO:0051649[establishment of localization in cell] GO:0060292[long-term synaptic depression] GO:0070062[extracellular exosome] GO:0070527[platelet aggregation] GO:0071346[cellular response to interferon-gamma] GO:0072659[protein localization to plasma membrane] GO:0098688[parallel fiber to Purkinje cell synapse] GO:0098793[presynapse] GO:0098794[postsynapse] GO:0098831[presynaptic active zone cytoplasmic component] GO:0098888[extrinsic component of presynaptic membrane] GO:0098978[glutamatergic synapse] GO:0099523[presynaptic cytosol] GO:0099525[presynaptic dense core vesicle exocytosis] GO:0106022[positive regulation of vesicle docking] GO:1903296[positive regulation of glutamate secretion, neurotransmission] GO:2000367[regulation of acrosomal vesicle exocytosis]
P61764 [Direct mapping] Syntaxin-binding protein 1
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Transporters Transporter channels and pores Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A1B0GUQ2 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A096LP52 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A096LP33 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A0D9SFW6 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A0D9SFQ7 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A0D9SG72 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A0D9SEP9 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A0D9SEH5 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A1B0GWF2 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A0D9SG72 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A1B0GTP9 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A1B0GVQ5 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A1B0GTP9 [Direct mapping] Syntaxin-binding protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
