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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q24.12
Chromosome location (bp)
119416446 - 119424434
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival 1,2,3,4,5. Acts by binding to integrins or membrane receptors such as NOTCH1 6,7,8. Essential regulator of hematopoietic stem and progenitor cell function 9. Inhibits myogenic differentiation through the activation of Notch-signaling pathway 10. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling 11. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival 12. Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts 13. Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification 14. Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway 15. Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement 16....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Growth factor
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Transporters Accessory Factors Involved in Transport THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0002062[chondrocyte differentiation] GO:0005112[Notch binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005737[cytoplasm] GO:0005921[gap junction] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0010468[regulation of gene expression] GO:0010761[fibroblast migration] GO:0010832[negative regulation of myotube differentiation] GO:0014909[smooth muscle cell migration] GO:0030308[negative regulation of cell growth] GO:0030424[axon] GO:0030425[dendrite] GO:0031012[extracellular matrix] GO:0033627[cell adhesion mediated by integrin] GO:0035767[endothelial cell chemotaxis] GO:0043025[neuronal cell body] GO:0043231[intracellular membrane-bounded organelle] GO:0044342[type B pancreatic cell proliferation] GO:0045747[positive regulation of Notch signaling pathway] GO:0046676[negative regulation of insulin secretion] GO:0048659[smooth muscle cell proliferation] GO:0050728[negative regulation of inflammatory response] GO:0050793[regulation of developmental process] GO:0060326[cell chemotaxis] GO:0060392[negative regulation of SMAD protein signal transduction] GO:0060548[negative regulation of cell death] GO:0061484[hematopoietic stem cell homeostasis] GO:0062023[collagen-containing extracellular matrix] GO:0070161[anchoring junction] GO:0071603[endothelial cell-cell adhesion] GO:0090027[negative regulation of monocyte chemotaxis] GO:1901223[negative regulation of NIK/NF-kappaB signaling] GO:1902731[negative regulation of chondrocyte proliferation] GO:1904057[negative regulation of sensory perception of pain] GO:1990523[bone regeneration]
The Human Protein Atlas project is funded
