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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.1
Chromosome location (bp)
42050513 - 42087461
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription 1. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) 2. The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 3. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C 4. TAF8 is involved in forming the TFIID-B module, together with TAF5 5. Mediates both basal and activator-dependent transcription 6. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts 7. Required for the integration of TAF10 in the TAF complex 8. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001112[DNA-templated transcription open complex formation] GO:0001833[inner cell mass cell proliferation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005669[transcription factor TFIID complex] GO:0005737[cytoplasm] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006468[protein phosphorylation] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0030154[cell differentiation] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045598[regulation of fat cell differentiation] GO:0046982[protein heterodimerization activity] GO:0048471[perinuclear region of cytoplasm] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0051457[maintenance of protein location in nucleus] GO:0060261[positive regulation of transcription initiation by RNA polymerase II]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001112[DNA-templated transcription open complex formation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005669[transcription factor TFIID complex] GO:0005737[cytoplasm] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006468[protein phosphorylation] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0030154[cell differentiation] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045598[regulation of fat cell differentiation] GO:0046982[protein heterodimerization activity] GO:0048471[perinuclear region of cytoplasm] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0051457[maintenance of protein location in nucleus] GO:0060261[positive regulation of transcription initiation by RNA polymerase II]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001112[DNA-templated transcription open complex formation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005669[transcription factor TFIID complex] GO:0005737[cytoplasm] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006468[protein phosphorylation] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0030154[cell differentiation] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045598[regulation of fat cell differentiation] GO:0046982[protein heterodimerization activity] GO:0048471[perinuclear region of cytoplasm] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0051457[maintenance of protein location in nucleus] GO:0060261[positive regulation of transcription initiation by RNA polymerase II]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001112[DNA-templated transcription open complex formation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005669[transcription factor TFIID complex] GO:0005737[cytoplasm] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006468[protein phosphorylation] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0030154[cell differentiation] GO:0042789[mRNA transcription by RNA polymerase II] GO:0045598[regulation of fat cell differentiation] GO:0046982[protein heterodimerization activity] GO:0048471[perinuclear region of cytoplasm] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0051457[maintenance of protein location in nucleus] GO:0060261[positive regulation of transcription initiation by RNA polymerase II]
The Human Protein Atlas project is funded
