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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cytoplasmic polyadenylation element binding protein 2
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
p15.32
Chromosome location (bp)
15002481 - 15070153
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers (By similarity). Required for cell cycle progression, specifically for the transition from metaphase to anaphase 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
RNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Translation regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
A0A5K1VW61 [Direct mapping] Cytoplasmic polyadenylation element-binding protein 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A5K1VW71 [Direct mapping] Cytoplasmic polyadenylation element-binding protein 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A5K1VW79 [Direct mapping] Cytoplasmic polyadenylation element-binding protein 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q7Z5Q1 [Direct mapping] Cytoplasmic polyadenylation element-binding protein 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000900[mRNA regulatory element binding translation repressor activity] GO:0003676[nucleic acid binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005095[GTPase inhibitor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006412[translation] GO:0006417[regulation of translation] GO:0008135[translation factor activity, RNA binding] GO:0032869[cellular response to insulin stimulus] GO:0034260[negative regulation of GTPase activity] GO:0034599[cellular response to oxidative stress] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0043005[neuron projection] GO:0043022[ribosome binding] GO:0043023[ribosomal large subunit binding] GO:0043024[ribosomal small subunit binding] GO:0045182[translation regulator activity] GO:0045202[synapse] GO:0071243[cellular response to arsenic-containing substance] GO:0071456[cellular response to hypoxia] GO:1900248[negative regulation of cytoplasmic translational elongation] GO:1990124[messenger ribonucleoprotein complex] GO:2000766[negative regulation of cytoplasmic translation]
A0A5K1VW93 [Direct mapping] Cytoplasmic polyadenylation element-binding protein 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q7Z5Q1 [Direct mapping] Cytoplasmic polyadenylation element-binding protein 2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000900[mRNA regulatory element binding translation repressor activity] GO:0003676[nucleic acid binding] GO:0003723[RNA binding] GO:0003730[mRNA 3'-UTR binding] GO:0005095[GTPase inhibitor activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006412[translation] GO:0006417[regulation of translation] GO:0008135[translation factor activity, RNA binding] GO:0032869[cellular response to insulin stimulus] GO:0034260[negative regulation of GTPase activity] GO:0034599[cellular response to oxidative stress] GO:0035925[mRNA 3'-UTR AU-rich region binding] GO:0043005[neuron projection] GO:0043022[ribosome binding] GO:0043023[ribosomal large subunit binding] GO:0043024[ribosomal small subunit binding] GO:0045182[translation regulator activity] GO:0045202[synapse] GO:0071243[cellular response to arsenic-containing substance] GO:0071456[cellular response to hypoxia] GO:1900248[negative regulation of cytoplasmic translational elongation] GO:1990124[messenger ribonucleoprotein complex] GO:2000766[negative regulation of cytoplasmic translation]
The Human Protein Atlas project is funded
