We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q14
Chromosome location (bp)
39581079 - 39599466
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions 1,2,3,4. Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis 5,6,7,8,9,10,11. Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis 12. Ligand for receptor CD47 13,14. Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS 15. Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). Negatively modulates wound healing, acting via CD47 (By similarity). Ligand for receptor CD36 16,17,18. Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (By similarity). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47 19,20,21,22. Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner 23. Ligand for immunoglobulin-like cell surface receptor SIRPA 24. Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA 25. Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). May be involved in age-related conditions, including metabolic dysregulation, during normal aging 26,27....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Heparin-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Angiogenesis, Apoptosis, Cell adhesion, Inflammatory response, Unfolded protein response
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666[response to hypoxia] GO:0001786[phosphatidylserine binding] GO:0001937[negative regulation of endothelial cell proliferation] GO:0001953[negative regulation of cell-matrix adhesion] GO:0001968[fibronectin binding] GO:0002040[sprouting angiogenesis] GO:0002544[chronic inflammatory response] GO:0002581[negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0002605[negative regulation of dendritic cell antigen processing and presentation] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005577[fibrinogen complex] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0006986[response to unfolded protein] GO:0007155[cell adhesion] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0009410[response to xenobiotic stimulus] GO:0009612[response to mechanical stimulus] GO:0009749[response to glucose] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0010595[positive regulation of endothelial cell migration] GO:0010596[negative regulation of endothelial cell migration] GO:0010748[negative regulation of long-chain fatty acid import across plasma membrane] GO:0010751[negative regulation of nitric oxide mediated signal transduction] GO:0010754[negative regulation of cGMP-mediated signaling] GO:0010757[negative regulation of plasminogen activation] GO:0010759[positive regulation of macrophage chemotaxis] GO:0010763[positive regulation of fibroblast migration] GO:0016477[cell migration] GO:0016525[negative regulation of angiogenesis] GO:0016529[sarcoplasmic reticulum] GO:0017134[fibroblast growth factor binding] GO:0018149[peptide cross-linking] GO:0030141[secretory granule] GO:0030169[low-density lipoprotein particle binding] GO:0030194[positive regulation of blood coagulation] GO:0030335[positive regulation of cell migration] GO:0030511[positive regulation of transforming growth factor beta receptor signaling pathway] GO:0031012[extracellular matrix] GO:0031091[platelet alpha granule] GO:0031093[platelet alpha granule lumen] GO:0032026[response to magnesium ion] GO:0032570[response to progesterone] GO:0032695[negative regulation of interleukin-12 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032914[positive regulation of transforming growth factor beta1 production] GO:0033574[response to testosterone] GO:0034605[cellular response to heat] GO:0034976[response to endoplasmic reticulum stress] GO:0040037[negative regulation of fibroblast growth factor receptor signaling pathway] GO:0042327[positive regulation of phosphorylation] GO:0042802[identical protein binding] GO:0043032[positive regulation of macrophage activation] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043236[laminin binding] GO:0043394[proteoglycan binding] GO:0043406[positive regulation of MAP kinase activity] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043537[negative regulation of blood vessel endothelial cell migration] GO:0043652[engulfment of apoptotic cell] GO:0045727[positive regulation of translation] GO:0045766[positive regulation of angiogenesis] GO:0048266[behavioral response to pain] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050431[transforming growth factor beta binding] GO:0050840[extracellular matrix binding] GO:0050921[positive regulation of chemotaxis] GO:0051592[response to calcium ion] GO:0051895[negative regulation of focal adhesion assembly] GO:0051897[positive regulation of protein kinase B signaling] GO:0051918[negative regulation of fibrinolysis] GO:0062023[collagen-containing extracellular matrix] GO:0070051[fibrinogen binding] GO:0070052[collagen V binding] GO:0070062[extracellular exosome] GO:0071356[cellular response to tumor necrosis factor] GO:0071363[cellular response to growth factor stimulus] GO:0071636[positive regulation of transforming growth factor beta production] GO:0090051[negative regulation of cell migration involved in sprouting angiogenesis] GO:1902043[positive regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1903588[negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1903671[negative regulation of sprouting angiogenesis] GO:2000353[positive regulation of endothelial cell apoptotic process] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2001027[negative regulation of endothelial cell chemotaxis] GO:2001237[negative regulation of extrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
