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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p22.2
Chromosome location (bp)
88852633 - 88891944
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA 1,2,3,4,5,6,7,8,9,10,11,12,13. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex 14,15,16,17,18. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle 19. Associates with chromatin to core promoter-specific regions 20,21. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element 22,23,24,25. Modulates transcription start site selection 26. Exhibits also autoacetyltransferase activity that contributes to the activated transcription 27....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Acyltransferase, DNA-binding, Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000776[kinetochore] GO:0000793[condensed chromosome] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000993[RNA polymerase II complex binding] GO:0001174[transcriptional start site selection at RNA polymerase II promoter] GO:0003677[DNA binding] GO:0004402[histone acetyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005669[transcription factor TFIID complex] GO:0005694[chromosome] GO:0006352[DNA-templated transcription initiation] GO:0006366[transcription by RNA polymerase II] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006473[protein acetylation] GO:0008270[zinc ion binding] GO:0010467[gene expression] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0016407[acetyltransferase activity] GO:0016570[histone modification] GO:0016604[nuclear body] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0017025[TBP-class protein binding] GO:0019083[viral transcription] GO:0032153[cell division site] GO:0032993[protein-DNA complex] GO:0042585[germinal vesicle] GO:0046872[metal ion binding] GO:0046966[nuclear thyroid hormone receptor binding] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0051177[meiotic sister chromatid cohesion] GO:0051225[spindle assembly] GO:0051276[chromosome organization] GO:0070897[transcription preinitiation complex assembly] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097550[transcription preinitiation complex] GO:0140297[DNA-binding transcription factor binding] GO:1904798[positive regulation of core promoter binding] GO:1990114[RNA polymerase II core complex assembly] GO:1990841[promoter-specific chromatin binding]
The Human Protein Atlas project is funded
