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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Nuclear receptors Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
Chromosome location (bp)
64084232 - 64338112
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0007267[cell-cell signaling] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0014070[response to organic cyclic compound] GO:0019899[enzyme binding] GO:0030284[nuclear estrogen receptor activity] GO:0030308[negative regulation of cell growth] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0033993[response to lipid] GO:0034056[estrogen response element binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048019[receptor antagonist activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0071392[cellular response to estradiol stimulus] GO:0097159[organic cyclic compound binding] GO:2000272[negative regulation of signaling receptor activity]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0007267[cell-cell signaling] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0014070[response to organic cyclic compound] GO:0019899[enzyme binding] GO:0030284[nuclear estrogen receptor activity] GO:0030308[negative regulation of cell growth] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0033993[response to lipid] GO:0034056[estrogen response element binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048019[receptor antagonist activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0071392[cellular response to estradiol stimulus] GO:0097159[organic cyclic compound binding] GO:2000272[negative regulation of signaling receptor activity]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0007267[cell-cell signaling] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0014070[response to organic cyclic compound] GO:0019899[enzyme binding] GO:0030284[nuclear estrogen receptor activity] GO:0030308[negative regulation of cell growth] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0033993[response to lipid] GO:0034056[estrogen response element binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048019[receptor antagonist activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0071392[cellular response to estradiol stimulus] GO:0097159[organic cyclic compound binding] GO:2000272[negative regulation of signaling receptor activity]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0007267[cell-cell signaling] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0014070[response to organic cyclic compound] GO:0019899[enzyme binding] GO:0030284[nuclear estrogen receptor activity] GO:0030308[negative regulation of cell growth] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0033993[response to lipid] GO:0034056[estrogen response element binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048019[receptor antagonist activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0071392[cellular response to estradiol stimulus] GO:0097159[organic cyclic compound binding] GO:2000272[negative regulation of signaling receptor activity]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0007267[cell-cell signaling] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0014070[response to organic cyclic compound] GO:0019899[enzyme binding] GO:0030284[nuclear estrogen receptor activity] GO:0030308[negative regulation of cell growth] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0033993[response to lipid] GO:0034056[estrogen response element binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048019[receptor antagonist activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0071392[cellular response to estradiol stimulus] GO:0097159[organic cyclic compound binding] GO:2000272[negative regulation of signaling receptor activity]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0007267[cell-cell signaling] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0014070[response to organic cyclic compound] GO:0019899[enzyme binding] GO:0030284[nuclear estrogen receptor activity] GO:0030308[negative regulation of cell growth] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0033993[response to lipid] GO:0034056[estrogen response element binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048019[receptor antagonist activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0071392[cellular response to estradiol stimulus] GO:0097159[organic cyclic compound binding] GO:2000272[negative regulation of signaling receptor activity]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0007267[cell-cell signaling] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0014070[response to organic cyclic compound] GO:0019899[enzyme binding] GO:0030284[nuclear estrogen receptor activity] GO:0030308[negative regulation of cell growth] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0033993[response to lipid] GO:0034056[estrogen response element binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048019[receptor antagonist activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0071392[cellular response to estradiol stimulus] GO:0097159[organic cyclic compound binding] GO:2000272[negative regulation of signaling receptor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Reproductive system diseases Reproductive system diseases
Show all
GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005496[steroid binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0008270[zinc ion binding] GO:0014070[response to organic cyclic compound] GO:0030284[nuclear estrogen receptor activity] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0033993[response to lipid] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0046872[metal ion binding] GO:0071392[cellular response to estradiol stimulus] GO:0097159[organic cyclic compound binding]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003707[nuclear steroid receptor activity] GO:0004879[nuclear receptor activity] GO:0005496[steroid binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005739[mitochondrion] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007165[signal transduction] GO:0007267[cell-cell signaling] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0014070[response to organic cyclic compound] GO:0019899[enzyme binding] GO:0030284[nuclear estrogen receptor activity] GO:0030308[negative regulation of cell growth] GO:0030518[intracellular steroid hormone receptor signaling pathway] GO:0030520[intracellular estrogen receptor signaling pathway] GO:0033993[response to lipid] GO:0034056[estrogen response element binding] GO:0043231[intracellular membrane-bounded organelle] GO:0043565[sequence-specific DNA binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048019[receptor antagonist activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0071392[cellular response to estradiol stimulus] GO:0097159[organic cyclic compound binding] GO:2000272[negative regulation of signaling receptor activity]
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