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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q23.3
Chromosome location (bp)
82626965 - 83800640
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell adhesion
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001938[positive regulation of endothelial cell proliferation] GO:0001954[positive regulation of cell-matrix adhesion] GO:0002040[sprouting angiogenesis] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0007155[cell adhesion] GO:0007156[homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007162[negative regulation of cell adhesion] GO:0007266[Rho protein signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0016020[membrane] GO:0016339[calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0016342[catenin complex] GO:0016601[Rac protein signal transduction] GO:0030032[lamellipodium assembly] GO:0030100[regulation of endocytosis] GO:0030169[low-density lipoprotein particle binding] GO:0030335[positive regulation of cell migration] GO:0042058[regulation of epidermal growth factor receptor signaling pathway] GO:0042803[protein homodimerization activity] GO:0043005[neuron projection] GO:0043542[endothelial cell migration] GO:0043616[keratinocyte proliferation] GO:0045296[cadherin binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050850[positive regulation of calcium-mediated signaling] GO:0050927[positive regulation of positive chemotaxis] GO:0051668[localization within membrane] GO:0055096[low-density lipoprotein particle mediated signaling] GO:0055100[adiponectin binding] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0071813[lipoprotein particle binding] GO:0098609[cell-cell adhesion] GO:0098742[cell-cell adhesion via plasma-membrane adhesion molecules]
Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001938[positive regulation of endothelial cell proliferation] GO:0001954[positive regulation of cell-matrix adhesion] GO:0002040[sprouting angiogenesis] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0007155[cell adhesion] GO:0007156[homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007162[negative regulation of cell adhesion] GO:0007266[Rho protein signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0016020[membrane] GO:0016339[calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0016342[catenin complex] GO:0016601[Rac protein signal transduction] GO:0030032[lamellipodium assembly] GO:0030100[regulation of endocytosis] GO:0030169[low-density lipoprotein particle binding] GO:0030335[positive regulation of cell migration] GO:0042058[regulation of epidermal growth factor receptor signaling pathway] GO:0042803[protein homodimerization activity] GO:0043005[neuron projection] GO:0043542[endothelial cell migration] GO:0043616[keratinocyte proliferation] GO:0045296[cadherin binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050850[positive regulation of calcium-mediated signaling] GO:0050927[positive regulation of positive chemotaxis] GO:0051668[localization within membrane] GO:0055096[low-density lipoprotein particle mediated signaling] GO:0055100[adiponectin binding] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0071813[lipoprotein particle binding] GO:0098609[cell-cell adhesion] GO:0098742[cell-cell adhesion via plasma-membrane adhesion molecules]
Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001938[positive regulation of endothelial cell proliferation] GO:0001954[positive regulation of cell-matrix adhesion] GO:0002040[sprouting angiogenesis] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0005901[caveola] GO:0005925[focal adhesion] GO:0007155[cell adhesion] GO:0007156[homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007162[negative regulation of cell adhesion] GO:0007266[Rho protein signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0016020[membrane] GO:0016339[calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0016342[catenin complex] GO:0016601[Rac protein signal transduction] GO:0030032[lamellipodium assembly] GO:0030100[regulation of endocytosis] GO:0030169[low-density lipoprotein particle binding] GO:0030335[positive regulation of cell migration] GO:0042058[regulation of epidermal growth factor receptor signaling pathway] GO:0042803[protein homodimerization activity] GO:0043005[neuron projection] GO:0043542[endothelial cell migration] GO:0043616[keratinocyte proliferation] GO:0045296[cadherin binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050850[positive regulation of calcium-mediated signaling] GO:0050927[positive regulation of positive chemotaxis] GO:0051668[localization within membrane] GO:0055096[low-density lipoprotein particle mediated signaling] GO:0055100[adiponectin binding] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0071813[lipoprotein particle binding] GO:0098609[cell-cell adhesion] GO:0098742[cell-cell adhesion via plasma-membrane adhesion molecules]
The Human Protein Atlas project is funded
