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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
p13.3
Chromosome location (bp)
2537979 - 2603188
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables 3-phosphoinositide-dependent protein kinase activity; phospholipase activator activity; and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of protein kinase activity; and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection; cytosol; and plasma membrane. Implicated in prostate cancer. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
O15530 [Direct mapping] 3-phosphoinositide-dependent protein kinase 1
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004676[3-phosphoinositide-dependent protein kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0010518[positive regulation of phospholipase activity] GO:0016004[phospholipase activator activity] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019722[calcium-mediated signaling] GO:0030036[actin cytoskeleton organization] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0032148[activation of protein kinase B activity] GO:0032869[cellular response to insulin stimulus] GO:0035556[intracellular signal transduction] GO:0042995[cell projection] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043274[phospholipase binding] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045766[positive regulation of angiogenesis] GO:0046777[protein autophosphorylation] GO:0051281[positive regulation of release of sequestered calcium ion into cytosol] GO:0070161[anchoring junction] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0097191[extrinsic apoptotic signaling pathway] GO:0106310[protein serine kinase activity] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903672[positive regulation of sprouting angiogenesis] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000352[negative regulation of endothelial cell apoptotic process]
O15530 [Direct mapping] 3-phosphoinositide-dependent protein kinase 1
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0003323[type B pancreatic cell development] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004676[3-phosphoinositide-dependent protein kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006972[hyperosmotic response] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0008286[insulin receptor signaling pathway] GO:0010518[positive regulation of phospholipase activity] GO:0010594[regulation of endothelial cell migration] GO:0010667[negative regulation of cardiac muscle cell apoptotic process] GO:0014069[postsynaptic density] GO:0016004[phospholipase activator activity] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019209[kinase activator activity] GO:0019722[calcium-mediated signaling] GO:0030036[actin cytoskeleton organization] GO:0030295[protein kinase activator activity] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031410[cytoplasmic vesicle] GO:0032148[activation of protein kinase B activity] GO:0032869[cellular response to insulin stimulus] GO:0034122[negative regulation of toll-like receptor signaling pathway] GO:0035556[intracellular signal transduction] GO:0042995[cell projection] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043274[phospholipase binding] GO:0043304[regulation of mast cell degranulation] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045766[positive regulation of angiogenesis] GO:0046777[protein autophosphorylation] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0051281[positive regulation of release of sequestered calcium ion into cytosol] GO:0070161[anchoring junction] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0097191[extrinsic apoptotic signaling pathway] GO:0106310[protein serine kinase activity] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903672[positive regulation of sprouting angiogenesis] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000352[negative regulation of endothelial cell apoptotic process]
E9PER6 [Direct mapping] 3-phosphoinositide-dependent protein kinase 1
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
O15530 [Direct mapping] 3-phosphoinositide-dependent protein kinase 1
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004676[3-phosphoinositide-dependent protein kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0010518[positive regulation of phospholipase activity] GO:0016004[phospholipase activator activity] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019722[calcium-mediated signaling] GO:0030036[actin cytoskeleton organization] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0032148[activation of protein kinase B activity] GO:0032869[cellular response to insulin stimulus] GO:0035556[intracellular signal transduction] GO:0042995[cell projection] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043274[phospholipase binding] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045766[positive regulation of angiogenesis] GO:0046777[protein autophosphorylation] GO:0051281[positive regulation of release of sequestered calcium ion into cytosol] GO:0070161[anchoring junction] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0097191[extrinsic apoptotic signaling pathway] GO:0106310[protein serine kinase activity] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903672[positive regulation of sprouting angiogenesis] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000352[negative regulation of endothelial cell apoptotic process]
H3BPW1 [Direct mapping] 3-phosphoinositide-dependent protein kinase 1
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
