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PCTP
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PROTEIN SUMMARY SECTION OVERVIEW GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

PCTP
Synonyms STARD2
Gene descriptioni

Full gene name according to HGNC.

Phosphatidylcholine transfer protein
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Metabolic proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 17
Cytoband q22
Chromosome location (bp) 55751051 - 55842830
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

5
Ensembl ENSG00000141179 (version 109)
Entrez gene 58488
HGNC HGNC:8752
UniProt Q9UKL6 (UniProt - Evidence at protein level)
neXtProt NX_Q9UKL6
GeneCards PCTP
Antibodypedia PCTP antibodies


PROTEIN FUNCTION
Protein function (UniProt)i

Useful information about the protein provided by UniProt.

Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.... show less
Biological process (UniProt)i

Keywords assigned by UniProt to proteins because they are involved in a particular biological process.

Lipid transport, Transport
Ligand (UniProt)i

Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.

Lipid-binding
Gene summary (Entrez)i

Useful information about the gene from Entrez

Enables phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Involved in phospholipid transport. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
PCTP-201
ENSP00000268896
ENST00000268896
Q9UKL6
[Direct mapping] Phosphatidylcholine transfer protein
Show all
Q549N3
[Target identity:100%; Query identity:100%] Phosphatidylcholine transfer protein; Phosphatidylcholine transfer protein, isoform CRA_c; cDNA, FLJ95327, highly similar to Homo sapiens phosphatidylcholine transfer protein (PCTP), mRNA
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0008525 [phosphatidylcholine transporter activity]
GO:0015914 [phospholipid transport]
GO:0031210 [phosphatidylcholine binding]
GO:0120163 [negative regulation of cold-induced thermogenesis]
Show all
214 aa
24.8 kDa
No 0
PCTP-202
ENSP00000325181
ENST00000325214
Q9UKL6
[Direct mapping] Phosphatidylcholine transfer protein
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0008525 [phosphatidylcholine transporter activity]
GO:0015914 [phospholipid transport]
GO:0031210 [phosphatidylcholine binding]
GO:0120163 [negative regulation of cold-induced thermogenesis]
Show all
142 aa
16.8 kDa
No 0
PCTP-205
ENSP00000461676
ENST00000572536
I3L4Z8
[Direct mapping] Phosphatidylcholine transfer protein
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008289 [lipid binding]
Show all
146 aa
16.4 kDa
No 0
PCTP-206
ENSP00000460437
ENST00000573500
I3L3H0
[Direct mapping] Phosphatidylcholine transfer protein; Phosphatidylcholine transfer protein, isoform CRA_a
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008289 [lipid binding]
Show all
219 aa
25.5 kDa
No 0
PCTP-207
ENSP00000459793
ENST00000576183
I3L2M9
[Direct mapping] Phosphatidylcholine transfer protein; Phosphatidylcholine transfer protein, isoform CRA_b
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008289 [lipid binding]
Show all
203 aa
23.4 kDa
No 0

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