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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
18
Cytoband
q21.32
Chromosome location (bp)
59899996 - 59904305
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state. [provided by RefSeq, Aug 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q13794 [Direct mapping] Phorbol-12-myristate-13-acetate-induced protein 1
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A0A0S2Z4V2 [Target identity:100%; Query identity:100%] Phorbol-12-myristate-13-acetate-induced protein 1 isoform 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0010498[proteasomal protein catabolic process] GO:0010907[positive regulation of glucose metabolic process] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0042149[cellular response to glucose starvation] GO:0043029[T cell homeostasis] GO:0043065[positive regulation of apoptotic process] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043331[response to dsRNA] GO:0043517[positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0046902[regulation of mitochondrial membrane permeability] GO:0051607[defense response to virus] GO:0071456[cellular response to hypoxia] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072593[reactive oxygen species metabolic process] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097193[intrinsic apoptotic signaling pathway] GO:1902043[positive regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
Q13794 [Direct mapping] Phorbol-12-myristate-13-acetate-induced protein 1
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A0A0S2Z490 [Target identity:100%; Query identity:100%] Phorbol-12-myristate-13-acetate-induced protein 1 isoform 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005829[cytosol] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0010498[proteasomal protein catabolic process] GO:0010907[positive regulation of glucose metabolic process] GO:0010917[negative regulation of mitochondrial membrane potential] GO:0042149[cellular response to glucose starvation] GO:0043029[T cell homeostasis] GO:0043065[positive regulation of apoptotic process] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043331[response to dsRNA] GO:0043517[positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0046902[regulation of mitochondrial membrane permeability] GO:0051607[defense response to virus] GO:0071456[cellular response to hypoxia] GO:0072332[intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072593[reactive oxygen species metabolic process] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097193[intrinsic apoptotic signaling pathway] GO:1902043[positive regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
