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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.3
Chromosome location (bp)
6772708 - 6857366
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001784[phosphotyrosine residue binding] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007166[cell surface receptor signaling pathway] GO:0007264[small GTPase mediated signal transduction] GO:0008361[regulation of cell size] GO:0016477[cell migration] GO:0030168[platelet activation] GO:0031295[T cell costimulation] GO:0035556[intracellular signal transduction] GO:0038095[Fc-epsilon receptor signaling pathway] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043087[regulation of GTPase activity] GO:0046872[metal ion binding] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0071466[cellular response to xenobiotic stimulus]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784[phosphotyrosine residue binding] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0006909[phagocytosis] GO:0006955[immune response] GO:0007166[cell surface receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007229[integrin-mediated signaling pathway] GO:0007264[small GTPase mediated signal transduction] GO:0008361[regulation of cell size] GO:0016477[cell migration] GO:0030168[platelet activation] GO:0030217[T cell differentiation] GO:0030593[neutrophil chemotaxis] GO:0031295[T cell costimulation] GO:0035556[intracellular signal transduction] GO:0038095[Fc-epsilon receptor signaling pathway] GO:0038096[Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042110[T cell activation] GO:0043087[regulation of GTPase activity] GO:0043547[positive regulation of GTPase activity] GO:0045785[positive regulation of cell adhesion] GO:0045954[positive regulation of natural killer cell mediated cytotoxicity] GO:0046872[metal ion binding] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0051056[regulation of small GTPase mediated signal transduction] GO:0071466[cellular response to xenobiotic stimulus] GO:0072593[reactive oxygen species metabolic process] GO:0140031[phosphorylation-dependent protein binding]
The Human Protein Atlas project is funded
