We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets RAS pathway related proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q32.33
Chromosome location (bp)
104769349 - 104795751
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis 1,2,3,4,5. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates 6,7,8,9. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported 10,11,12,13. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (By similarity). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport 14. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (By similarity). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase) 15. Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis 16. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the TORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1 17. Also regulates the TORC1 signaling pathway by catalyzing phosphorylation of CASTOR1 18. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization 19. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319' 20. FOXO3 and FOXO4 are phosphorylated on equivalent sites 21. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein) 22. The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 23. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) 24,25. AKT mediates the antiapoptotic effects of IGF-I (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly 26. May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3 27. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation 28,29. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation 30. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity 31. Phosphorylation of BAD stimulates its pro-apoptotic activity 32. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53 33. Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility 34. Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation 35. Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization 36. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation 37. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation 38. Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor 39. Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity 40. Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1, thereby inhibiting METTL1 methyltransferase activity 41....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Transporters Accessory Factors Involved in Transport MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the breast and female genital organs Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of skin Other congenital malformations Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003376[sphingosine-1-phosphate receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005975[carbohydrate metabolic process] GO:0005977[glycogen metabolic process] GO:0005978[glycogen biosynthetic process] GO:0005979[regulation of glycogen biosynthetic process] GO:0006006[glucose metabolic process] GO:0006417[regulation of translation] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006606[protein import into nucleus] GO:0006809[nitric oxide biosynthetic process] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006979[response to oxidative stress] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007399[nervous system development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0008643[carbohydrate transport] GO:0009408[response to heat] GO:0010507[negative regulation of autophagy] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010748[negative regulation of long-chain fatty acid import across plasma membrane] GO:0010761[fibroblast migration] GO:0010907[positive regulation of glucose metabolic process] GO:0010918[positive regulation of mitochondrial membrane potential] GO:0010951[negative regulation of endopeptidase activity] GO:0010975[regulation of neuron projection development] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015630[microtubule cytoskeleton] GO:0016020[membrane] GO:0016242[negative regulation of macroautophagy] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030235[nitric-oxide synthase regulator activity] GO:0030291[protein serine/threonine kinase inhibitor activity] GO:0030307[positive regulation of cell growth] GO:0030334[regulation of cell migration] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031295[T cell costimulation] GO:0031397[negative regulation of protein ubiquitination] GO:0031929[TOR signaling] GO:0031982[vesicle] GO:0031999[negative regulation of fatty acid beta-oxidation] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034405[response to fluid shear stress] GO:0034614[cellular response to reactive oxygen species] GO:0035556[intracellular signal transduction] GO:0035655[interleukin-18-mediated signaling pathway] GO:0038061[NIK/NF-kappaB signaling] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276[anoikis] GO:0043325[phosphatidylinositol-3,4-bisphosphate binding] GO:0043488[regulation of mRNA stability] GO:0043491[protein kinase B signaling] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045429[positive regulation of nitric oxide biosynthetic process] GO:0045600[positive regulation of fat cell differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045861[negative regulation of proteolysis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046326[positive regulation of glucose import] GO:0046777[protein autophosphorylation] GO:0046889[positive regulation of lipid biosynthetic process] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051000[positive regulation of nitric-oxide synthase activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051247[positive regulation of protein metabolic process] GO:0060079[excitatory postsynaptic potential] GO:0060416[response to growth hormone] GO:0060644[mammary gland epithelial cell differentiation] GO:0070141[response to UV-A] GO:0070848[response to growth factor] GO:0071276[cellular response to cadmium ion] GO:0071356[cellular response to tumor necrosis factor] GO:0071889[14-3-3 protein binding] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0072655[establishment of protein localization to mitochondrion] GO:0072656[maintenance of protein location in mitochondrion] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0098794[postsynapse] GO:0099104[potassium channel activator activity] GO:0106310[protein serine kinase activity] GO:0140052[cellular response to oxidised low-density lipoprotein particle stimulus] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900182[positive regulation of protein localization to nucleus] GO:1901215[negative regulation of neuron death] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903038[negative regulation of leukocyte cell-cell adhesion] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903721[positive regulation of I-kappaB phosphorylation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990418[response to insulin-like growth factor stimulus] GO:2000074[regulation of type B pancreatic cell development] GO:2000402[negative regulation of lymphocyte migration] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Transporters Accessory Factors Involved in Transport MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the breast and female genital organs Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of skin Other congenital malformations Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003376[sphingosine-1-phosphate receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005975[carbohydrate metabolic process] GO:0005977[glycogen metabolic process] GO:0005978[glycogen biosynthetic process] GO:0005979[regulation of glycogen biosynthetic process] GO:0006006[glucose metabolic process] GO:0006417[regulation of translation] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006606[protein import into nucleus] GO:0006809[nitric oxide biosynthetic process] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006979[response to oxidative stress] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007399[nervous system development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0008643[carbohydrate transport] GO:0009408[response to heat] GO:0010507[negative regulation of autophagy] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010748[negative regulation of long-chain fatty acid import across plasma membrane] GO:0010761[fibroblast migration] GO:0010907[positive regulation of glucose metabolic process] GO:0010918[positive regulation of mitochondrial membrane potential] GO:0010951[negative regulation of endopeptidase activity] GO:0010975[regulation of neuron projection development] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015630[microtubule cytoskeleton] GO:0016020[membrane] GO:0016242[negative regulation of macroautophagy] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030235[nitric-oxide synthase regulator activity] GO:0030291[protein serine/threonine kinase inhibitor activity] GO:0030307[positive regulation of cell growth] GO:0030334[regulation of cell migration] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031295[T cell costimulation] GO:0031397[negative regulation of protein ubiquitination] GO:0031929[TOR signaling] GO:0031982[vesicle] GO:0031999[negative regulation of fatty acid beta-oxidation] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034405[response to fluid shear stress] GO:0034614[cellular response to reactive oxygen species] GO:0035556[intracellular signal transduction] GO:0035655[interleukin-18-mediated signaling pathway] GO:0038061[NIK/NF-kappaB signaling] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276[anoikis] GO:0043325[phosphatidylinositol-3,4-bisphosphate binding] GO:0043488[regulation of mRNA stability] GO:0043491[protein kinase B signaling] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045429[positive regulation of nitric oxide biosynthetic process] GO:0045600[positive regulation of fat cell differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045861[negative regulation of proteolysis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046326[positive regulation of glucose import] GO:0046777[protein autophosphorylation] GO:0046889[positive regulation of lipid biosynthetic process] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051000[positive regulation of nitric-oxide synthase activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051247[positive regulation of protein metabolic process] GO:0060079[excitatory postsynaptic potential] GO:0060416[response to growth hormone] GO:0060644[mammary gland epithelial cell differentiation] GO:0070141[response to UV-A] GO:0070848[response to growth factor] GO:0071276[cellular response to cadmium ion] GO:0071356[cellular response to tumor necrosis factor] GO:0071889[14-3-3 protein binding] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0072655[establishment of protein localization to mitochondrion] GO:0072656[maintenance of protein location in mitochondrion] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0098794[postsynapse] GO:0099104[potassium channel activator activity] GO:0106310[protein serine kinase activity] GO:0140052[cellular response to oxidised low-density lipoprotein particle stimulus] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900182[positive regulation of protein localization to nucleus] GO:1901215[negative regulation of neuron death] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903038[negative regulation of leukocyte cell-cell adhesion] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903721[positive regulation of I-kappaB phosphorylation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990418[response to insulin-like growth factor stimulus] GO:2000074[regulation of type B pancreatic cell development] GO:2000402[negative regulation of lymphocyte migration] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Transporters Accessory Factors Involved in Transport MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the breast and female genital organs Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of skin Other congenital malformations Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003376[sphingosine-1-phosphate receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005975[carbohydrate metabolic process] GO:0005977[glycogen metabolic process] GO:0005978[glycogen biosynthetic process] GO:0005979[regulation of glycogen biosynthetic process] GO:0006006[glucose metabolic process] GO:0006417[regulation of translation] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006606[protein import into nucleus] GO:0006809[nitric oxide biosynthetic process] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006979[response to oxidative stress] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007399[nervous system development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0008643[carbohydrate transport] GO:0009408[response to heat] GO:0010507[negative regulation of autophagy] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010748[negative regulation of long-chain fatty acid import across plasma membrane] GO:0010761[fibroblast migration] GO:0010907[positive regulation of glucose metabolic process] GO:0010918[positive regulation of mitochondrial membrane potential] GO:0010951[negative regulation of endopeptidase activity] GO:0010975[regulation of neuron projection development] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015630[microtubule cytoskeleton] GO:0016020[membrane] GO:0016242[negative regulation of macroautophagy] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030235[nitric-oxide synthase regulator activity] GO:0030291[protein serine/threonine kinase inhibitor activity] GO:0030307[positive regulation of cell growth] GO:0030334[regulation of cell migration] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031295[T cell costimulation] GO:0031397[negative regulation of protein ubiquitination] GO:0031929[TOR signaling] GO:0031982[vesicle] GO:0031999[negative regulation of fatty acid beta-oxidation] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034405[response to fluid shear stress] GO:0034614[cellular response to reactive oxygen species] GO:0035556[intracellular signal transduction] GO:0035655[interleukin-18-mediated signaling pathway] GO:0038061[NIK/NF-kappaB signaling] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276[anoikis] GO:0043325[phosphatidylinositol-3,4-bisphosphate binding] GO:0043488[regulation of mRNA stability] GO:0043491[protein kinase B signaling] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045429[positive regulation of nitric oxide biosynthetic process] GO:0045600[positive regulation of fat cell differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045861[negative regulation of proteolysis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046326[positive regulation of glucose import] GO:0046777[protein autophosphorylation] GO:0046889[positive regulation of lipid biosynthetic process] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051000[positive regulation of nitric-oxide synthase activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051247[positive regulation of protein metabolic process] GO:0060079[excitatory postsynaptic potential] GO:0060416[response to growth hormone] GO:0060644[mammary gland epithelial cell differentiation] GO:0070141[response to UV-A] GO:0070848[response to growth factor] GO:0071276[cellular response to cadmium ion] GO:0071356[cellular response to tumor necrosis factor] GO:0071889[14-3-3 protein binding] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0072655[establishment of protein localization to mitochondrion] GO:0072656[maintenance of protein location in mitochondrion] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0098794[postsynapse] GO:0099104[potassium channel activator activity] GO:0106310[protein serine kinase activity] GO:0140052[cellular response to oxidised low-density lipoprotein particle stimulus] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900182[positive regulation of protein localization to nucleus] GO:1901215[negative regulation of neuron death] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903038[negative regulation of leukocyte cell-cell adhesion] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903721[positive regulation of I-kappaB phosphorylation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990418[response to insulin-like growth factor stimulus] GO:2000074[regulation of type B pancreatic cell development] GO:2000402[negative regulation of lymphocyte migration] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
A0A804HJM6 [Direct mapping] Non-specific serine/threonine protein kinase
Show all
MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the breast and female genital organs Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of skin Other congenital malformations Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the breast and female genital organs Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of skin Other congenital malformations Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Transporters Accessory Factors Involved in Transport MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the breast and female genital organs Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of skin Other congenital malformations Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003376[sphingosine-1-phosphate receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005975[carbohydrate metabolic process] GO:0005977[glycogen metabolic process] GO:0005978[glycogen biosynthetic process] GO:0005979[regulation of glycogen biosynthetic process] GO:0006006[glucose metabolic process] GO:0006417[regulation of translation] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006606[protein import into nucleus] GO:0006809[nitric oxide biosynthetic process] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006979[response to oxidative stress] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007399[nervous system development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0008643[carbohydrate transport] GO:0009408[response to heat] GO:0010507[negative regulation of autophagy] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010748[negative regulation of long-chain fatty acid import across plasma membrane] GO:0010761[fibroblast migration] GO:0010907[positive regulation of glucose metabolic process] GO:0010918[positive regulation of mitochondrial membrane potential] GO:0010951[negative regulation of endopeptidase activity] GO:0010975[regulation of neuron projection development] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015630[microtubule cytoskeleton] GO:0016020[membrane] GO:0016242[negative regulation of macroautophagy] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030235[nitric-oxide synthase regulator activity] GO:0030291[protein serine/threonine kinase inhibitor activity] GO:0030307[positive regulation of cell growth] GO:0030334[regulation of cell migration] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031295[T cell costimulation] GO:0031397[negative regulation of protein ubiquitination] GO:0031929[TOR signaling] GO:0031982[vesicle] GO:0031999[negative regulation of fatty acid beta-oxidation] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034405[response to fluid shear stress] GO:0034614[cellular response to reactive oxygen species] GO:0035556[intracellular signal transduction] GO:0035655[interleukin-18-mediated signaling pathway] GO:0038061[NIK/NF-kappaB signaling] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276[anoikis] GO:0043325[phosphatidylinositol-3,4-bisphosphate binding] GO:0043488[regulation of mRNA stability] GO:0043491[protein kinase B signaling] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045429[positive regulation of nitric oxide biosynthetic process] GO:0045600[positive regulation of fat cell differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045861[negative regulation of proteolysis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046326[positive regulation of glucose import] GO:0046777[protein autophosphorylation] GO:0046889[positive regulation of lipid biosynthetic process] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051000[positive regulation of nitric-oxide synthase activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051247[positive regulation of protein metabolic process] GO:0060079[excitatory postsynaptic potential] GO:0060416[response to growth hormone] GO:0060644[mammary gland epithelial cell differentiation] GO:0070141[response to UV-A] GO:0070848[response to growth factor] GO:0071276[cellular response to cadmium ion] GO:0071356[cellular response to tumor necrosis factor] GO:0071889[14-3-3 protein binding] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0072655[establishment of protein localization to mitochondrion] GO:0072656[maintenance of protein location in mitochondrion] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0098794[postsynapse] GO:0099104[potassium channel activator activity] GO:0106310[protein serine kinase activity] GO:0140052[cellular response to oxidised low-density lipoprotein particle stimulus] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900182[positive regulation of protein localization to nucleus] GO:1901215[negative regulation of neuron death] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903038[negative regulation of leukocyte cell-cell adhesion] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903721[positive regulation of I-kappaB phosphorylation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990418[response to insulin-like growth factor stimulus] GO:2000074[regulation of type B pancreatic cell development] GO:2000402[negative regulation of lymphocyte migration] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Transporters Accessory Factors Involved in Transport MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the breast and female genital organs Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of skin Other congenital malformations Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003376[sphingosine-1-phosphate receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005975[carbohydrate metabolic process] GO:0005977[glycogen metabolic process] GO:0005978[glycogen biosynthetic process] GO:0005979[regulation of glycogen biosynthetic process] GO:0006006[glucose metabolic process] GO:0006417[regulation of translation] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006606[protein import into nucleus] GO:0006809[nitric oxide biosynthetic process] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006979[response to oxidative stress] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007399[nervous system development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0008643[carbohydrate transport] GO:0009408[response to heat] GO:0010507[negative regulation of autophagy] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010748[negative regulation of long-chain fatty acid import across plasma membrane] GO:0010761[fibroblast migration] GO:0010907[positive regulation of glucose metabolic process] GO:0010918[positive regulation of mitochondrial membrane potential] GO:0010951[negative regulation of endopeptidase activity] GO:0010975[regulation of neuron projection development] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015630[microtubule cytoskeleton] GO:0016020[membrane] GO:0016242[negative regulation of macroautophagy] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030235[nitric-oxide synthase regulator activity] GO:0030291[protein serine/threonine kinase inhibitor activity] GO:0030307[positive regulation of cell growth] GO:0030334[regulation of cell migration] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031295[T cell costimulation] GO:0031397[negative regulation of protein ubiquitination] GO:0031929[TOR signaling] GO:0031982[vesicle] GO:0031999[negative regulation of fatty acid beta-oxidation] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034405[response to fluid shear stress] GO:0034614[cellular response to reactive oxygen species] GO:0035556[intracellular signal transduction] GO:0035655[interleukin-18-mediated signaling pathway] GO:0038061[NIK/NF-kappaB signaling] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276[anoikis] GO:0043325[phosphatidylinositol-3,4-bisphosphate binding] GO:0043488[regulation of mRNA stability] GO:0043491[protein kinase B signaling] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045429[positive regulation of nitric oxide biosynthetic process] GO:0045600[positive regulation of fat cell differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045861[negative regulation of proteolysis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046326[positive regulation of glucose import] GO:0046777[protein autophosphorylation] GO:0046889[positive regulation of lipid biosynthetic process] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051000[positive regulation of nitric-oxide synthase activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051247[positive regulation of protein metabolic process] GO:0060079[excitatory postsynaptic potential] GO:0060416[response to growth hormone] GO:0060644[mammary gland epithelial cell differentiation] GO:0070141[response to UV-A] GO:0070848[response to growth factor] GO:0071276[cellular response to cadmium ion] GO:0071356[cellular response to tumor necrosis factor] GO:0071889[14-3-3 protein binding] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0072655[establishment of protein localization to mitochondrion] GO:0072656[maintenance of protein location in mitochondrion] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0098794[postsynapse] GO:0099104[potassium channel activator activity] GO:0106310[protein serine kinase activity] GO:0140052[cellular response to oxidised low-density lipoprotein particle stimulus] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900182[positive regulation of protein localization to nucleus] GO:1901215[negative regulation of neuron death] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903038[negative regulation of leukocyte cell-cell adhesion] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903721[positive regulation of I-kappaB phosphorylation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990418[response to insulin-like growth factor stimulus] GO:2000074[regulation of type B pancreatic cell development] GO:2000402[negative regulation of lymphocyte migration] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the breast and female genital organs Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of skin Other congenital malformations Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Transporters Accessory Factors Involved in Transport MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the breast and female genital organs Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of skin Other congenital malformations Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003376[sphingosine-1-phosphate receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005975[carbohydrate metabolic process] GO:0005977[glycogen metabolic process] GO:0005978[glycogen biosynthetic process] GO:0005979[regulation of glycogen biosynthetic process] GO:0006006[glucose metabolic process] GO:0006417[regulation of translation] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006606[protein import into nucleus] GO:0006809[nitric oxide biosynthetic process] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006979[response to oxidative stress] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007399[nervous system development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0008643[carbohydrate transport] GO:0009408[response to heat] GO:0010507[negative regulation of autophagy] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010748[negative regulation of long-chain fatty acid import across plasma membrane] GO:0010761[fibroblast migration] GO:0010907[positive regulation of glucose metabolic process] GO:0010918[positive regulation of mitochondrial membrane potential] GO:0010951[negative regulation of endopeptidase activity] GO:0010975[regulation of neuron projection development] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015630[microtubule cytoskeleton] GO:0016020[membrane] GO:0016242[negative regulation of macroautophagy] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030235[nitric-oxide synthase regulator activity] GO:0030291[protein serine/threonine kinase inhibitor activity] GO:0030307[positive regulation of cell growth] GO:0030334[regulation of cell migration] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031295[T cell costimulation] GO:0031397[negative regulation of protein ubiquitination] GO:0031929[TOR signaling] GO:0031982[vesicle] GO:0031999[negative regulation of fatty acid beta-oxidation] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034405[response to fluid shear stress] GO:0034614[cellular response to reactive oxygen species] GO:0035556[intracellular signal transduction] GO:0035655[interleukin-18-mediated signaling pathway] GO:0038061[NIK/NF-kappaB signaling] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276[anoikis] GO:0043325[phosphatidylinositol-3,4-bisphosphate binding] GO:0043488[regulation of mRNA stability] GO:0043491[protein kinase B signaling] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045429[positive regulation of nitric oxide biosynthetic process] GO:0045600[positive regulation of fat cell differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045861[negative regulation of proteolysis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046326[positive regulation of glucose import] GO:0046777[protein autophosphorylation] GO:0046889[positive regulation of lipid biosynthetic process] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051000[positive regulation of nitric-oxide synthase activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051247[positive regulation of protein metabolic process] GO:0060079[excitatory postsynaptic potential] GO:0060416[response to growth hormone] GO:0060644[mammary gland epithelial cell differentiation] GO:0070141[response to UV-A] GO:0070848[response to growth factor] GO:0071276[cellular response to cadmium ion] GO:0071356[cellular response to tumor necrosis factor] GO:0071889[14-3-3 protein binding] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0072655[establishment of protein localization to mitochondrion] GO:0072656[maintenance of protein location in mitochondrion] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0098794[postsynapse] GO:0099104[potassium channel activator activity] GO:0106310[protein serine kinase activity] GO:0140052[cellular response to oxidised low-density lipoprotein particle stimulus] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900182[positive regulation of protein localization to nucleus] GO:1901215[negative regulation of neuron death] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903038[negative regulation of leukocyte cell-cell adhesion] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903721[positive regulation of I-kappaB phosphorylation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990418[response to insulin-like growth factor stimulus] GO:2000074[regulation of type B pancreatic cell development] GO:2000402[negative regulation of lymphocyte migration] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Transporters Accessory Factors Involved in Transport MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the breast and female genital organs Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of skin Other congenital malformations Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001649[osteoblast differentiation] GO:0001893[maternal placenta development] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003376[sphingosine-1-phosphate receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005819[spindle] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005911[cell-cell junction] GO:0005975[carbohydrate metabolic process] GO:0005977[glycogen metabolic process] GO:0005978[glycogen biosynthetic process] GO:0005979[regulation of glycogen biosynthetic process] GO:0006006[glucose metabolic process] GO:0006417[regulation of translation] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006606[protein import into nucleus] GO:0006809[nitric oxide biosynthetic process] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006954[inflammatory response] GO:0006979[response to oxidative stress] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007281[germ cell development] GO:0007399[nervous system development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0008637[apoptotic mitochondrial changes] GO:0008643[carbohydrate transport] GO:0009408[response to heat] GO:0009725[response to hormone] GO:0010033[response to organic substance] GO:0010467[gene expression] GO:0010507[negative regulation of autophagy] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010748[negative regulation of long-chain fatty acid import across plasma membrane] GO:0010761[fibroblast migration] GO:0010763[positive regulation of fibroblast migration] GO:0010765[positive regulation of sodium ion transport] GO:0010907[positive regulation of glucose metabolic process] GO:0010918[positive regulation of mitochondrial membrane potential] GO:0010951[negative regulation of endopeptidase activity] GO:0010975[regulation of neuron projection development] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015630[microtubule cytoskeleton] GO:0016020[membrane] GO:0016242[negative regulation of macroautophagy] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0019901[protein kinase binding] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030163[protein catabolic process] GO:0030235[nitric-oxide synthase regulator activity] GO:0030291[protein serine/threonine kinase inhibitor activity] GO:0030307[positive regulation of cell growth] GO:0030334[regulation of cell migration] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031295[T cell costimulation] GO:0031397[negative regulation of protein ubiquitination] GO:0031641[regulation of myelination] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0031929[TOR signaling] GO:0031982[vesicle] GO:0031999[negative regulation of fatty acid beta-oxidation] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032094[response to food] GO:0032287[peripheral nervous system myelin maintenance] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032869[cellular response to insulin stimulus] GO:0032880[regulation of protein localization] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034405[response to fluid shear stress] GO:0034614[cellular response to reactive oxygen species] GO:0035556[intracellular signal transduction] GO:0035655[interleukin-18-mediated signaling pathway] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0036064[ciliary basal body] GO:0036294[cellular response to decreased oxygen levels] GO:0038061[NIK/NF-kappaB signaling] GO:0042593[glucose homeostasis] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043276[anoikis] GO:0043325[phosphatidylinositol-3,4-bisphosphate binding] GO:0043488[regulation of mRNA stability] GO:0043491[protein kinase B signaling] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045429[positive regulation of nitric oxide biosynthetic process] GO:0045600[positive regulation of fat cell differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045861[negative regulation of proteolysis] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046326[positive regulation of glucose import] GO:0046622[positive regulation of organ growth] GO:0046777[protein autophosphorylation] GO:0046889[positive regulation of lipid biosynthetic process] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048266[behavioral response to pain] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051000[positive regulation of nitric-oxide synthase activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051146[striated muscle cell differentiation] GO:0051247[positive regulation of protein metabolic process] GO:0060079[excitatory postsynaptic potential] GO:0060416[response to growth hormone] GO:0060644[mammary gland epithelial cell differentiation] GO:0060709[glycogen cell differentiation involved in embryonic placenta development] GO:0060716[labyrinthine layer blood vessel development] GO:0070141[response to UV-A] GO:0070848[response to growth factor] GO:0071276[cellular response to cadmium ion] GO:0071356[cellular response to tumor necrosis factor] GO:0071363[cellular response to growth factor stimulus] GO:0071364[cellular response to epidermal growth factor stimulus] GO:0071380[cellular response to prostaglandin E stimulus] GO:0071889[14-3-3 protein binding] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0072655[establishment of protein localization to mitochondrion] GO:0072656[maintenance of protein location in mitochondrion] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097011[cellular response to granulocyte macrophage colony-stimulating factor stimulus] GO:0097194[execution phase of apoptosis] GO:0098794[postsynapse] GO:0098978[glutamatergic synapse] GO:0099104[potassium channel activator activity] GO:0099175[regulation of postsynapse organization] GO:0106310[protein serine kinase activity] GO:0140052[cellular response to oxidised low-density lipoprotein particle stimulus] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900182[positive regulation of protein localization to nucleus] GO:1901215[negative regulation of neuron death] GO:1901653[cellular response to peptide] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903038[negative regulation of leukocyte cell-cell adhesion] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903721[positive regulation of I-kappaB phosphorylation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990418[response to insulin-like growth factor stimulus] GO:2000010[positive regulation of protein localization to cell surface] GO:2000074[regulation of type B pancreatic cell development] GO:2000402[negative regulation of lymphocyte migration] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of the breast and female genital organs Cancers of eye, brain, and central nervous system Congenital malformations Congenital malformations of skin Other congenital malformations Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001934[positive regulation of protein phosphorylation] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002042[cell migration involved in sprouting angiogenesis] GO:0003376[sphingosine-1-phosphate receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004712[protein serine/threonine/tyrosine kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005547[phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005975[carbohydrate metabolic process] GO:0005977[glycogen metabolic process] GO:0005978[glycogen biosynthetic process] GO:0005979[regulation of glycogen biosynthetic process] GO:0006006[glucose metabolic process] GO:0006417[regulation of translation] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006606[protein import into nucleus] GO:0006809[nitric oxide biosynthetic process] GO:0006915[apoptotic process] GO:0006924[activation-induced cell death of T cells] GO:0006979[response to oxidative stress] GO:0007165[signal transduction] GO:0007173[epidermal growth factor receptor signaling pathway] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007399[nervous system development] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0008643[carbohydrate transport] GO:0009408[response to heat] GO:0010507[negative regulation of autophagy] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0010748[negative regulation of long-chain fatty acid import across plasma membrane] GO:0010761[fibroblast migration] GO:0010907[positive regulation of glucose metabolic process] GO:0010918[positive regulation of mitochondrial membrane potential] GO:0010951[negative regulation of endopeptidase activity] GO:0010975[regulation of neuron projection development] GO:0014065[phosphatidylinositol 3-kinase signaling] GO:0015630[microtubule cytoskeleton] GO:0016020[membrane] GO:0016242[negative regulation of macroautophagy] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019221[cytokine-mediated signaling pathway] GO:0019899[enzyme binding] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030235[nitric-oxide synthase regulator activity] GO:0030291[protein serine/threonine kinase inhibitor activity] GO:0030307[positive regulation of cell growth] GO:0030334[regulation of cell migration] GO:0031234[extrinsic component of cytoplasmic side of plasma membrane] GO:0031295[T cell costimulation] GO:0031397[negative regulation of protein ubiquitination] GO:0031929[TOR signaling] GO:0031982[vesicle] GO:0031999[negative regulation of fatty acid beta-oxidation] GO:0032079[positive regulation of endodeoxyribonuclease activity] GO:0032091[negative regulation of protein binding] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0034405[response to fluid shear stress] GO:0034614[cellular response to reactive oxygen species] GO:0035556[intracellular signal transduction] GO:0035655[interleukin-18-mediated signaling pathway] GO:0038061[NIK/NF-kappaB signaling] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276[anoikis] GO:0043325[phosphatidylinositol-3,4-bisphosphate binding] GO:0043488[regulation of mRNA stability] GO:0043491[protein kinase B signaling] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045429[positive regulation of nitric oxide biosynthetic process] GO:0045600[positive regulation of fat cell differentiation] GO:0045725[positive regulation of glycogen biosynthetic process] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045746[negative regulation of Notch signaling pathway] GO:0045861[negative regulation of proteolysis] GO:0045893[positive regulation of DNA-templated transcription] GO:0046326[positive regulation of glucose import] GO:0046777[protein autophosphorylation] GO:0046889[positive regulation of lipid biosynthetic process] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051000[positive regulation of nitric-oxide synthase activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051247[positive regulation of protein metabolic process] GO:0060079[excitatory postsynaptic potential] GO:0060416[response to growth hormone] GO:0060644[mammary gland epithelial cell differentiation] GO:0070141[response to UV-A] GO:0070848[response to growth factor] GO:0071276[cellular response to cadmium ion] GO:0071356[cellular response to tumor necrosis factor] GO:0071889[14-3-3 protein binding] GO:0071901[negative regulation of protein serine/threonine kinase activity] GO:0072655[establishment of protein localization to mitochondrion] GO:0072656[maintenance of protein location in mitochondrion] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0098794[postsynapse] GO:0099104[potassium channel activator activity] GO:0106310[protein serine kinase activity] GO:0140052[cellular response to oxidised low-density lipoprotein particle stimulus] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900182[positive regulation of protein localization to nucleus] GO:1901215[negative regulation of neuron death] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903038[negative regulation of leukocyte cell-cell adhesion] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1903721[positive regulation of I-kappaB phosphorylation] GO:1990090[cellular response to nerve growth factor stimulus] GO:1990418[response to insulin-like growth factor stimulus] GO:2000074[regulation of type B pancreatic cell development] GO:2000402[negative regulation of lymphocyte migration] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
The Human Protein Atlas project is funded
