MIDBRAIN - Expression summary
Protein expression
Substantia nigrai
h
m
l
n
Glial cells: Not detected
Neuronal cells: High
Neuronal projections: High
Synapses: High
RNA expressioni
Consensus:95.8 nTPM
HPA Brain:133.7 nTPM
GTEx:95.8 nTPM
FANTOM5:1.7 Scaled Tags Per Million
Pig:393.2 nTPM
Mouse:80.6 nTPM
Allen mouse:1.1 Expression energy

DORSAL RAPHE - Extended tissue profilei , antibody HPA012763
Glial cells Not detected
Neuronal cells Not detected
Neuronal projections Low
Synapses Not detected

DORSAL RAPHE - Extended tissue profilei , antibody CAB016249
Glial cells Not detected
Neuronal cells Not detected
Neuronal projections Medium
Synapses Medium

SUBSTANTIA NIGRA - Extended tissue profilei , antibody HPA012763
Glial cells Not detected
Neuronal cells Not detected
Neuronal projections Medium
Synapses Not detected

SUBSTANTIA NIGRA - Extended tissue profilei , antibody CAB016249
Glial cells Not detected
Neuronal cells Not detected
Neuronal projections High
Synapses Medium

SUBSTANTIA NIGRA - Extended tissue profilei , antibody CAB078172
Glial cells Not detected
Neuronal cells High
Neuronal projections High
Synapses High

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 133.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 8.4
2219 Male, age 76, both hemispheres 64.2
1833 Male, age 53, unknown 11.3
1830 Male, age 51, unknown 5.8
2586 Male, age 75, left hemisphere 1.5
2411 Female, age 72, unknown 1.0
2828 Female, age 72, unknown 0.5
1827 Male, age 72, unknown 0.1
1870 Female, age 42, unknown 0.0
2019 Male, age 18, unknown 0.0
2666 Male, age 74, left hemisphere 0.0
Dorsal raphe nucleus
nTPM: 1.6
2750 Male, age 76, both hemispheres 3.4
2298 Female, age 72, unknown 1.5
2047 Male, age 72, unknown 1.2
2016 Female, age 72, unknown 1.1
1828 Male, age 53, unknown 0.7
Inferior colliculus
nTPM: 0.1
1890 Male, age 53, unknown 0.5
2849 Male, age 72, unknown 0.2
1848 Female, age 42, unknown 0.0
2097 Female, age 72, unknown 0.0
Median raphe nucleus
nTPM: 1.1
2220 Male, age 76, midline 1.1
Periaquaductal grey, anterior
nTPM: 0.2
2502 Female, age 75, unknown 0.5
1795 Male, age 51, unknown 0.0
1947 Male, age 18, unknown 0.0
Periaquaductal grey, dorsal
nTPM: 0.2
1840 Male, age 53, unknown 0.7
1831 Male, age 72, unknown 0.1
2464 Female, age 72, unknown 0.0
2850 Male, age 76, both hemispheres 0.0
Periaquaductal grey, lateral
nTPM: 0.0
2053 Male, age 18, unknown 0.0
2140 Male, age 76, both hemispheres 0.0
2272 Male, age 74, both hemispheres 0.0
Pretectal area
nTPM: 0.2
1944 Female, age 72, unknown 1.1
1815 Male, age 53, unknown 0.5
2667 Female, age 75, unknown 0.5
2007 Male, age 72, unknown 0.1
1816 Male, age 51, unknown 0.0
1817 Female, age 42, unknown 0.0
2224 Female, age 72, unknown 0.0
2273 Male, age 74, both hemispheres 0.0
2316 Male, age 76, right hemisphere 0.0
2407 Male, age 75, both hemispheres 0.0
2825 Male, age 18, unknown 0.0
Red nucleus
nTPM: 0.8
2584 Male, age 75, left hemisphere 5.5
2769 Male, age 72, unknown 1.7
2725 Female, age 75, unknown 0.7
1821 Female, age 72, unknown 0.6
1904 Male, age 53, unknown 0.6
2227 Male, age 72, unknown 0.3
2785 Male, age 18, unknown 0.1
1865 Male, age 51, unknown 0.0
1954 Female, age 42, unknown 0.0
2503 Female, age 72, unknown 0.0
2588 Male, age 74, left hemisphere 0.0
2823 Male, age 76, right hemisphere 0.0
Substantia nigra
nTPM: 133.7
2699 Male, age 18, unknown 306.5
1916 Female, age 42, unknown 279.1
2665 Male, age 74, both hemispheres 244.3
2241 Male, age 72, unknown 122.9
1851 Male, age 51, unknown 120.5
1941 Male, age 53, unknown 117.4
2409 Female, age 72, unknown 96.4
2590 Female, age 75, unknown 21.5
1889 Female, age 72, unknown 20.2
2583 Male, age 75, right hemisphere 7.6
Superior colliculus
nTPM: 0.2
2087 Female, age 72, unknown 0.7
2668 Female, age 75, unknown 0.7
1796 Male, age 53, unknown 0.6
1995 Male, age 72, unknown 0.1
1839 Male, age 51, unknown 0.0
1895 Male, age 76, right hemisphere 0.0
1913 Female, age 42, unknown 0.0
2261 Male, age 18, unknown 0.0
2587 Male, age 74, left hemisphere 0.0
2664 Male, age 75, both hemispheres 0.0
Ventral tegmental area
nTPM: 71.2
1915 Female, age 42, unknown 169.8
2218 Male, age 76, both hemispheres 115.2
2410 Female, age 72, unknown 88.6
1942 Male, age 51, unknown 48.2
2223 Female, age 72, unknown 4.9
2021 Male, age 53, unknown 0.7

MIDBRAIN - GTEx RNA-seqi
Average nTPM 95.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 95.8
Samples: 139

Max nTPM: 423.7
Min nTPM: 0.0
Std nTPM: 112.4
Median nTPM: 50.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 423.7
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 413.1
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 387.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 364.1
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 363.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 357.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 353.8
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 324.3
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 323.2
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 322.7
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 322.5
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MIDBRAIN - FANTOM5 CAGEi
Max Scaled Tags Per Million 1.7
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 1.7
FF:10158-103A5 76 years, female 1.7

MIDBRAIN - Pig RNA-seqi
Average nTPM 393.2
Pig sample Sample description nTPM
Substantia nigra
nTPM: 393.2
Samples: 4

Max nTPM: 746.3
Min nTPM: 4.3
Sample A Female 569.0
Sample B Female 253.2
Sample C Male 746.3
Sample D Male 4.3
Midbrain
nTPM: 34.6
Samples: 4

Max nTPM: 137.1
Min nTPM: 0.1
Sample A Female 0.7
Sample B Female 137.1
Sample C Male 0.3
Sample D Male 0.1
Periaqueductal gray
nTPM: 4.5
Samples: 3

Max nTPM: 9.8
Min nTPM: 1.5
Sample B Female 1.5
Sample C Male 9.8
Sample D Male 2.2
Superior colliculi
nTPM: 0.3
Samples: 4

Max nTPM: 0.6
Min nTPM: 0.0
Sample A Female 0.6
Sample B Female 0.5
Sample C Male 0.0
Sample D Male 0.2

MIDBRAIN - Mouse RNA-seqi
Average nTPM 80.6
Mouse sample Sample description nTPM
Midbrain
nTPM: 80.6
Samples: 4

Max nTPM: 90.2
Min nTPM: 75.2
Sample A Male 75.2
Sample B Male 76.4
Sample C Female 90.2
Sample D Female 80.7

MIDBRAIN - Allen Mouse ISHi
Max Expression energy 1.1
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 1.1
79591365 Antisense, RP_071204_02_G05, Mouse strain C57BL/6J (56 days, male) 1.5
979 Antisense, RP_Baylor_102718, Mouse strain C57BL/6J (56 days, male) 0.8
978 Antisense, RP_Baylor_102718, Mouse strain C57BL/6J (56 days, male) 0.5
79761025 Antisense, RP_071204_02_G05, Mouse strain C57BL/6J (56 days, male) 0.4

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