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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
q13.33
Chromosome location (bp)
50854915 - 50860764
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protease, Serine protease
Gene summary (Entrez)i
Useful information about the gene from Entrez
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q546G3 [Target identity:100%; Query identity:100%] Kallikrein 3, (Prostate specific antigen), isoform CRA_m; Kallikrein A2; Prostate specific antigen; cDNA, FLJ93384, Homo sapiens kallikrein 3, (prostate specific antigen) (KLK3),transcript variant 1, mRNA
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Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002803[positive regulation of antibacterial peptide production] GO:0003073[regulation of systemic arterial blood pressure] GO:0004175[endopeptidase activity] GO:0004252[serine-type endopeptidase activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0006508[proteolysis] GO:0008233[peptidase activity] GO:0008236[serine-type peptidase activity] GO:0016525[negative regulation of angiogenesis] GO:0016787[hydrolase activity] GO:0016811[hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0019538[protein metabolic process] GO:0030141[secretory granule] GO:0031638[zymogen activation] GO:0032991[protein-containing complex] GO:0070062[extracellular exosome]
Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002803[positive regulation of antibacterial peptide production] GO:0003073[regulation of systemic arterial blood pressure] GO:0004175[endopeptidase activity] GO:0004252[serine-type endopeptidase activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0006508[proteolysis] GO:0008233[peptidase activity] GO:0008236[serine-type peptidase activity] GO:0016525[negative regulation of angiogenesis] GO:0016787[hydrolase activity] GO:0016811[hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0019538[protein metabolic process] GO:0030141[secretory granule] GO:0031638[zymogen activation] GO:0032991[protein-containing complex] GO:0070062[extracellular exosome]
Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002803[positive regulation of antibacterial peptide production] GO:0003073[regulation of systemic arterial blood pressure] GO:0004175[endopeptidase activity] GO:0004252[serine-type endopeptidase activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0006508[proteolysis] GO:0008233[peptidase activity] GO:0008236[serine-type peptidase activity] GO:0016525[negative regulation of angiogenesis] GO:0016787[hydrolase activity] GO:0016811[hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0019538[protein metabolic process] GO:0030141[secretory granule] GO:0031638[zymogen activation] GO:0032991[protein-containing complex] GO:0070062[extracellular exosome]
The Human Protein Atlas project is funded
