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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p22.3
Chromosome location (bp)
85580761 - 85584589
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Growth factor binding, Heparin-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Cell adhesion, Chemotaxis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001649[osteoblast differentiation] GO:0001934[positive regulation of protein phosphorylation] GO:0002041[intussusceptive angiogenesis] GO:0003181[atrioventricular valve morphogenesis] GO:0003278[apoptotic process involved in heart morphogenesis] GO:0003281[ventricular septum development] GO:0005178[integrin binding] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005788[endoplasmic reticulum lumen] GO:0006915[apoptotic process] GO:0006935[chemotaxis] GO:0007155[cell adhesion] GO:0007165[signal transduction] GO:0008201[heparin binding] GO:0010518[positive regulation of phospholipase activity] GO:0010811[positive regulation of cell-substrate adhesion] GO:0019838[growth factor binding] GO:0030198[extracellular matrix organization] GO:0030335[positive regulation of cell migration] GO:0030501[positive regulation of bone mineralization] GO:0030513[positive regulation of BMP signaling pathway] GO:0031012[extracellular matrix] GO:0033690[positive regulation of osteoblast proliferation] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044319[wound healing, spreading of cells] GO:0045597[positive regulation of cell differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045860[positive regulation of protein kinase activity] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050793[regulation of developmental process] GO:0050840[extracellular matrix binding] GO:0060413[atrial septum morphogenesis] GO:0060548[negative regulation of cell death] GO:0060591[chondroblast differentiation] GO:0060710[chorio-allantoic fusion] GO:0060716[labyrinthine layer blood vessel development] GO:0061036[positive regulation of cartilage development] GO:0062023[collagen-containing extracellular matrix] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0072593[reactive oxygen species metabolic process] GO:0098609[cell-cell adhesion] GO:2000304[positive regulation of ceramide biosynthetic process]
The Human Protein Atlas project is funded
