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                                  • TINAGL1
                                  SINGLE CELL TYPE LIVER Show tissue menu
                                  ADIPOSE TISSUE BONE MARROW BRAIN BREAST BRONCHUS COLON ENDOMETRIUM ESOPHAGUS
                                  EYE FALLOPIAN TUBE HEART MUSCLE KIDNEY LIVER LUNG LYMPH NODE OVARY
                                  PANCREAS PBMC PLACENTA PROSTATE RECTUM SALIVARY GLAND SKELETAL MUSCLE SKIN
                                  SMALL INTESTINE SPLEEN STOMACH TESTIS THYMUS TONGUE VASCULAR
                                  Cell type proteome
                                  Specialized epithelial cells
                                  Endothelial cells
                                  Muscle cells
                                  Mesenchymal cells
                                  Blood & immune cells
                                  LIVERi

                                  RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot (top) and a bar chart (bottom).

                                  - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single Cell Type section and 2) cluster color, which assigns a unique color to each cluster. Thre are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,โ‰ฅ75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon


                                  - The BAR CHART shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single Cell Type section and 2) cluster color, which assigns a unique color to each cluster.

                                  Cell type color
                                  Cluster color
                                  Colored according to cell type group
                                  Colored according to clusters
                                  Intensity
                                  Interval
                                  Hexagon
                                  Scatter plot, all cells color scale - % of max
                                  Scatter plot, all cells color scale - fixed intervals
                                  Hexagon, average of all cells
                                  -6-4-202468101214UMAP-8-6-4-202468101214UMAPc-0c-1c-2c-3c-4c-5c-6c-7c-8c-9c-10c-11c-12c-13c-14c-15c-16c-17c-18c-19
                                  Cluster Cell type Expression (nTPM)
                                  0 380
                                  c-0 Hepatocytes
                                  c-1 T-cells
                                  c-2 Kupffer cells
                                  c-3 Plasma cells
                                  c-4 Hepatocytes
                                  c-5 Endothelial cells
                                  c-6 Kupffer cells
                                  c-7 Smooth muscle cells
                                  c-8 T-cells
                                  c-9 Hepatocytes
                                  c-10 Kupffer cells
                                  c-11 Fibroblasts
                                  c-12 Hepatocytes
                                  c-13 T-cells
                                  c-14 T-cells
                                  c-15 Kupffer cells
                                  c-16 B-cells
                                  c-17 Cholangiocytes
                                  c-18 Hepatocytes
                                  c-19 Erythroid cells


                                  CELL TYPE MARKERSi

                                  The heatmap in this section shows expression of the currently selected gene (on top) and well-known cell type markers in the different single cell type clusters of this tissue. The panel on the left shows which cell type each marker is associated with. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.

                                  Hover the mouse-pointer over the individual data points (squares) to see nTPM level and Z-score. Clicking on a gene name redirects to the corresponding gene page.
                                  Z-score is when you normalize a variable such that the standard deviation is 1 and the mean is 0. Thus, all the genes are easier to compare, as they have the same center and distribution.

                                  Max-norm
                                  Z-score
                                  Fraction of highest expression
                                  log(nTPM) z-score
                                  TINAGL1CD19CR2MS4A1GZMBIL3RAALAS2CA1CEBPEHDCMS4A2CD163CD68MARCOMRC1MSR1FCGR3AKIR2DL4PIM2CD3ECD4CD8AFOXP3IL17ACD34PECAM1SELESLC2A1VWFMBPMPZS100BSOX10COL3A1FBN1LUMACTA2ACTG2CNN1MYH11ELF3KRT19MUC5BALBFGAFGGHPXHepatocytes c-0T-cells c-1Kupffer cells c-2Plasma cells c-3Hepatocytes c-4Endothelial cells c-5Kupffer cells c-6Smooth muscle cells c-7T-cells c-8Hepatocytes c-9Kupffer cells c-10Fibroblasts c-11Hepatocytes c-12T-cells c-13T-cells c-14Kupffer cells c-15B-cells c-16Cholangiocytes c-17Hepatocytes c-18Erythroid cells c-19Current geneB-cellsDendritic cellsErythroid cellsGranulocytesMacrophagesMonocytesNK-cellsPlasma cellsT-cellsEndothelial cellsSchwann cellsFibroblastsSmooth muscle cellsCholangiocytesHepatocytes00.250.50.751-4-2024

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