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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q35
Chromosome location (bp)
218568580 - 218597080
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000289[nuclear-transcribed mRNA poly(A) tail shortening] GO:0000932[P-body] GO:0005154[epidermal growth factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006402[mRNA catabolic process] GO:0006417[regulation of translation] GO:0007548[sex differentiation] GO:0016020[membrane] GO:0017148[negative regulation of translation] GO:0019900[kinase binding] GO:0019904[protein domain specific binding] GO:0030014[CCR4-NOT complex] GO:0030015[CCR4-NOT core complex] GO:0030374[nuclear receptor coactivator activity] GO:0031047[gene silencing by RNA] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033147[negative regulation of intracellular estrogen receptor signaling pathway] GO:0042803[protein homodimerization activity] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0045893[positive regulation of DNA-templated transcription]
Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000289[nuclear-transcribed mRNA poly(A) tail shortening] GO:0000932[P-body] GO:0005154[epidermal growth factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006402[mRNA catabolic process] GO:0006417[regulation of translation] GO:0007548[sex differentiation] GO:0016020[membrane] GO:0017148[negative regulation of translation] GO:0019900[kinase binding] GO:0019904[protein domain specific binding] GO:0030014[CCR4-NOT complex] GO:0030015[CCR4-NOT core complex] GO:0030374[nuclear receptor coactivator activity] GO:0031047[gene silencing by RNA] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033147[negative regulation of intracellular estrogen receptor signaling pathway] GO:0042803[protein homodimerization activity] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0045893[positive regulation of DNA-templated transcription]
SCAMPI predicted membrane proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000289[nuclear-transcribed mRNA poly(A) tail shortening] GO:0000932[P-body] GO:0005154[epidermal growth factor receptor binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006402[mRNA catabolic process] GO:0006417[regulation of translation] GO:0007548[sex differentiation] GO:0016020[membrane] GO:0017148[negative regulation of translation] GO:0019900[kinase binding] GO:0019904[protein domain specific binding] GO:0030014[CCR4-NOT complex] GO:0030015[CCR4-NOT core complex] GO:0030374[nuclear receptor coactivator activity] GO:0031047[gene silencing by RNA] GO:0032991[protein-containing complex] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033147[negative regulation of intracellular estrogen receptor signaling pathway] GO:0042803[protein homodimerization activity] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0045893[positive regulation of DNA-templated transcription]
The Human Protein Atlas project is funded
