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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q12.3
Chromosome location (bp)
101827991 - 101861022
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in regulation of NF-kappa-B transcription factor complexes 1,2. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation 3. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer 4. Seems also to activate NF-kappa-B-mediated transcription 5. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters 6. Promotes transcription of LCN2 and DEFB4 7. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0010468[regulation of gene expression] GO:0016607[nuclear speck] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0050729[positive regulation of inflammatory response] GO:0050852[T cell receptor signaling pathway] GO:2000321[positive regulation of T-helper 17 cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002224[toll-like receptor signaling pathway] GO:0002250[adaptive immune response] GO:0002285[lymphocyte activation involved in immune response] GO:0002317[plasma cell differentiation] GO:0002456[T cell mediated immunity] GO:0002544[chronic inflammatory response] GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006366[transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0009410[response to xenobiotic stimulus] GO:0010033[response to organic substance] GO:0010467[gene expression] GO:0010468[regulation of gene expression] GO:0016064[immunoglobulin mediated immune response] GO:0016607[nuclear speck] GO:0019221[cytokine-mediated signaling pathway] GO:0030216[keratinocyte differentiation] GO:0030217[T cell differentiation] GO:0032496[response to lipopolysaccharide] GO:0032980[keratinocyte activation] GO:0034097[response to cytokine] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0042100[B cell proliferation] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043588[skin development] GO:0043616[keratinocyte proliferation] GO:0043966[histone H3 acetylation] GO:0045063[T-helper 1 cell differentiation] GO:0045190[isotype switching] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048536[spleen development] GO:0048873[homeostasis of number of cells within a tissue] GO:0050729[positive regulation of inflammatory response] GO:0050776[regulation of immune response] GO:0050829[defense response to Gram-negative bacterium] GO:0050852[T cell receptor signaling pathway] GO:0050853[B cell receptor signaling pathway] GO:0051568[histone H3-K4 methylation] GO:0051593[response to folic acid] GO:0061436[establishment of skin barrier] GO:0070897[transcription preinitiation complex assembly] GO:0071222[cellular response to lipopolysaccharide] GO:0071310[cellular response to organic substance] GO:0071345[cellular response to cytokine stimulus] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0072539[T-helper 17 cell differentiation] GO:0072718[response to cisplatin] GO:0080182[histone H3-K4 trimethylation] GO:0090594[inflammatory response to wounding] GO:0097194[execution phase of apoptosis] GO:0097398[cellular response to interleukin-17] GO:0098773[skin epidermis development] GO:0140459[response to Gram-positive bacterium] GO:1904019[epithelial cell apoptotic process] GO:1990117[B cell receptor apoptotic signaling pathway] GO:2000321[positive regulation of T-helper 17 cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005634[nucleus] GO:0010468[regulation of gene expression] GO:0016607[nuclear speck] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0050729[positive regulation of inflammatory response] GO:0050852[T cell receptor signaling pathway] GO:2000321[positive regulation of T-helper 17 cell differentiation]
The Human Protein Atlas project is funded
