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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q33.1
Chromosome location (bp)
151029945 - 151093577
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG 1. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Inflammatory response
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q15025 [Direct mapping] TNFAIP3-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006412[translation] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007159[leukocyte cell-cell adhesion] GO:0009101[glycoprotein biosynthetic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:1903003[positive regulation of protein deubiquitination]
A0A0A0MRZ4 [Direct mapping] TNFAIP3-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050727[regulation of inflammatory response] GO:0070373[negative regulation of ERK1 and ERK2 cascade]
H0YC17 [Direct mapping] TNFAIP3-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050727[regulation of inflammatory response] GO:0070373[negative regulation of ERK1 and ERK2 cascade]
Q15025 [Direct mapping] TNFAIP3-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006412[translation] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007159[leukocyte cell-cell adhesion] GO:0009101[glycoprotein biosynthetic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:1903003[positive regulation of protein deubiquitination]
E7EW68 [Direct mapping] TNFAIP3-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050727[regulation of inflammatory response] GO:0070373[negative regulation of ERK1 and ERK2 cascade]
Q15025 [Direct mapping] TNFAIP3-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006412[translation] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007159[leukocyte cell-cell adhesion] GO:0009101[glycoprotein biosynthetic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:1903003[positive regulation of protein deubiquitination]
E7EWG2 [Direct mapping] TNFAIP3-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050727[regulation of inflammatory response] GO:0070373[negative regulation of ERK1 and ERK2 cascade]
Q15025 [Direct mapping] TNFAIP3-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006412[translation] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007159[leukocyte cell-cell adhesion] GO:0009101[glycoprotein biosynthetic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:1903003[positive regulation of protein deubiquitination]
E7EW15 [Direct mapping] TNFAIP3-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005654[nucleoplasm] GO:0005829[cytosol] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050727[regulation of inflammatory response] GO:0070373[negative regulation of ERK1 and ERK2 cascade]
Q15025 [Direct mapping] TNFAIP3-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006412[translation] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007159[leukocyte cell-cell adhesion] GO:0009101[glycoprotein biosynthetic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:1903003[positive regulation of protein deubiquitination]
Q15025 [Direct mapping] TNFAIP3-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006412[translation] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007159[leukocyte cell-cell adhesion] GO:0009101[glycoprotein biosynthetic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:1903003[positive regulation of protein deubiquitination]
Q15025 [Direct mapping] TNFAIP3-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006412[translation] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007159[leukocyte cell-cell adhesion] GO:0009101[glycoprotein biosynthetic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:1903003[positive regulation of protein deubiquitination]
Q15025 [Direct mapping] TNFAIP3-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006412[translation] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007159[leukocyte cell-cell adhesion] GO:0009101[glycoprotein biosynthetic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:1903003[positive regulation of protein deubiquitination]
Q15025 [Direct mapping] TNFAIP3-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006412[translation] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007159[leukocyte cell-cell adhesion] GO:0009101[glycoprotein biosynthetic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:1903003[positive regulation of protein deubiquitination]
Q15025 [Direct mapping] TNFAIP3-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006412[translation] GO:0006952[defense response] GO:0006954[inflammatory response] GO:0007159[leukocyte cell-cell adhesion] GO:0009101[glycoprotein biosynthetic process] GO:0042802[identical protein binding] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045071[negative regulation of viral genome replication] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050727[regulation of inflammatory response] GO:0050729[positive regulation of inflammatory response] GO:0051019[mitogen-activated protein kinase binding] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0071222[cellular response to lipopolysaccharide] GO:1903003[positive regulation of protein deubiquitination]
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