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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
q13.1
Chromosome location (bp)
71366222 - 71532374
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription 1. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) 2. The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 3. TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly 4,5,6. TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 7. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors 8,9. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 10. Phosphorylates GTF2A1 and GTF2F1 on Ser residues 11. Possesses DNA-binding activity 12. Essential for progression of the G1 phase of the cell cycle 13,14,15,16,17,18,19. Exhibits histone acetyltransferase activity towards histones H3 and H4 20....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Human disease related genes Nervous system diseases Other nervous and sensory system diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0000785[chromatin] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0001091[RNA polymerase II general transcription initiation factor binding] GO:0001181[RNA polymerase I general transcription initiation factor activity] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0004402[histone acetyltransferase activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005669[transcription factor TFIID complex] GO:0005730[nucleolus] GO:0006352[DNA-templated transcription initiation] GO:0006361[transcription initiation at RNA polymerase I promoter] GO:0006366[transcription by RNA polymerase II] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006468[protein phosphorylation] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0010629[negative regulation of gene expression] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016922[nuclear receptor binding] GO:0017025[TBP-class protein binding] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0030901[midbrain development] GO:0032092[positive regulation of protein binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034644[cellular response to UV] GO:0036369[transcription factor catabolic process] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043565[sequence-specific DNA binding] GO:0046777[protein autophosphorylation] GO:0046982[protein heterodimerization activity] GO:0050821[protein stabilization] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0061628[H3K27me3 modified histone binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070577[lysine-acetylated histone binding] GO:0071318[cellular response to ATP] GO:0071339[MLL1 complex] GO:0106310[protein serine kinase activity] GO:0140416[transcription regulator inhibitor activity] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1902806[regulation of cell cycle G1/S phase transition] GO:1903026[negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding] GO:1905524[negative regulation of protein autoubiquitination] GO:2000059[negative regulation of ubiquitin-dependent protein catabolic process] GO:2000825[positive regulation of androgen receptor activity]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Human disease related genes Nervous system diseases Other nervous and sensory system diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0000785[chromatin] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0001091[RNA polymerase II general transcription initiation factor binding] GO:0001181[RNA polymerase I general transcription initiation factor activity] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0004402[histone acetyltransferase activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005669[transcription factor TFIID complex] GO:0005730[nucleolus] GO:0006352[DNA-templated transcription initiation] GO:0006361[transcription initiation at RNA polymerase I promoter] GO:0006366[transcription by RNA polymerase II] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006468[protein phosphorylation] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0010629[negative regulation of gene expression] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016922[nuclear receptor binding] GO:0017025[TBP-class protein binding] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0030901[midbrain development] GO:0032092[positive regulation of protein binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034644[cellular response to UV] GO:0036369[transcription factor catabolic process] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043565[sequence-specific DNA binding] GO:0046777[protein autophosphorylation] GO:0046982[protein heterodimerization activity] GO:0050821[protein stabilization] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0061628[H3K27me3 modified histone binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070577[lysine-acetylated histone binding] GO:0071318[cellular response to ATP] GO:0071339[MLL1 complex] GO:0106310[protein serine kinase activity] GO:0140416[transcription regulator inhibitor activity] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1902806[regulation of cell cycle G1/S phase transition] GO:1903026[negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding] GO:1905524[negative regulation of protein autoubiquitination] GO:2000059[negative regulation of ubiquitin-dependent protein catabolic process] GO:2000825[positive regulation of androgen receptor activity]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Human disease related genes Nervous system diseases Other nervous and sensory system diseases Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0000785[chromatin] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0001091[RNA polymerase II general transcription initiation factor binding] GO:0001181[RNA polymerase I general transcription initiation factor activity] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0004402[histone acetyltransferase activity] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005669[transcription factor TFIID complex] GO:0005730[nucleolus] GO:0006352[DNA-templated transcription initiation] GO:0006361[transcription initiation at RNA polymerase I promoter] GO:0006366[transcription by RNA polymerase II] GO:0006367[transcription initiation at RNA polymerase II promoter] GO:0006468[protein phosphorylation] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0010629[negative regulation of gene expression] GO:0016251[RNA polymerase II general transcription initiation factor activity] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016922[nuclear receptor binding] GO:0017025[TBP-class protein binding] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0030901[midbrain development] GO:0032092[positive regulation of protein binding] GO:0032436[positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034644[cellular response to UV] GO:0036369[transcription factor catabolic process] GO:0042789[mRNA transcription by RNA polymerase II] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043565[sequence-specific DNA binding] GO:0046777[protein autophosphorylation] GO:0046982[protein heterodimerization activity] GO:0050821[protein stabilization] GO:0051123[RNA polymerase II preinitiation complex assembly] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0061628[H3K27me3 modified histone binding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070577[lysine-acetylated histone binding] GO:0071318[cellular response to ATP] GO:0071339[MLL1 complex] GO:0106310[protein serine kinase activity] GO:0140416[transcription regulator inhibitor activity] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1902806[regulation of cell cycle G1/S phase transition] GO:1903026[negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding] GO:1905524[negative regulation of protein autoubiquitination] GO:2000059[negative regulation of ubiquitin-dependent protein catabolic process] GO:2000825[positive regulation of androgen receptor activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001091[RNA polymerase II general transcription initiation factor binding] GO:0004402[histone acetyltransferase activity] GO:0005515[protein binding] GO:0005669[transcription factor TFIID complex] GO:0006366[transcription by RNA polymerase II] GO:0016570[histone modification] GO:0017025[TBP-class protein binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001091[RNA polymerase II general transcription initiation factor binding] GO:0004402[histone acetyltransferase activity] GO:0005669[transcription factor TFIID complex] GO:0006366[transcription by RNA polymerase II] GO:0016570[histone modification] GO:0017025[TBP-class protein binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001091[RNA polymerase II general transcription initiation factor binding] GO:0003677[DNA binding] GO:0004402[histone acetyltransferase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005669[transcription factor TFIID complex] GO:0006352[DNA-templated transcription initiation] GO:0006366[transcription by RNA polymerase II] GO:0007049[cell cycle] GO:0016570[histone modification] GO:0017025[TBP-class protein binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Nervous system diseases Other nervous and sensory system diseases Other diseases Mental and behavioural disorders Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001091[RNA polymerase II general transcription initiation factor binding] GO:0003677[DNA binding] GO:0004402[histone acetyltransferase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005669[transcription factor TFIID complex] GO:0006352[DNA-templated transcription initiation] GO:0006366[transcription by RNA polymerase II] GO:0007049[cell cycle] GO:0016570[histone modification] GO:0017025[TBP-class protein binding]
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