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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
p21.3
Chromosome location (bp)
21967752 - 21995301
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. [P42771] Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity). Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. [Q8N726] ...show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding [Q8N726]
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0001953[negative regulation of cell-matrix adhesion] GO:0003723[RNA binding] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019901[protein kinase binding] GO:0030308[negative regulation of cell growth] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0034393[positive regulation of smooth muscle cell apoptotic process] GO:0035985[senescence-associated heterochromatin focus] GO:0042326[negative regulation of phosphorylation] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0051059[NF-kappaB binding] GO:0051726[regulation of cell cycle] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000111[positive regulation of macrophage apoptotic process]
Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014)
Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0001953[negative regulation of cell-matrix adhesion] GO:0003723[RNA binding] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0019901[protein kinase binding] GO:0030308[negative regulation of cell growth] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0034393[positive regulation of smooth muscle cell apoptotic process] GO:0035985[senescence-associated heterochromatin focus] GO:0042326[negative regulation of phosphorylation] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0051059[NF-kappaB binding] GO:0051726[regulation of cell cycle] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000111[positive regulation of macrophage apoptotic process]
Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0001953[negative regulation of cell-matrix adhesion] GO:0003723[RNA binding] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0019901[protein kinase binding] GO:0030308[negative regulation of cell growth] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0034393[positive regulation of smooth muscle cell apoptotic process] GO:0035985[senescence-associated heterochromatin focus] GO:0042326[negative regulation of phosphorylation] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0051059[NF-kappaB binding] GO:0051726[regulation of cell cycle] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000111[positive regulation of macrophage apoptotic process]
Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0001953[negative regulation of cell-matrix adhesion] GO:0003723[RNA binding] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0019901[protein kinase binding] GO:0030308[negative regulation of cell growth] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0034393[positive regulation of smooth muscle cell apoptotic process] GO:0035985[senescence-associated heterochromatin focus] GO:0042326[negative regulation of phosphorylation] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0051059[NF-kappaB binding] GO:0051726[regulation of cell cycle] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000111[positive regulation of macrophage apoptotic process]
Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005829[cytosol] GO:0006364[rRNA processing] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007049[cell cycle] GO:0008285[negative regulation of cell population proliferation] GO:0008637[apoptotic mitochondrial changes] GO:0010389[regulation of G2/M transition of mitotic cell cycle] GO:0010628[positive regulation of gene expression] GO:0016604[nuclear body] GO:0016925[protein sumoylation] GO:0019789[SUMO transferase activity] GO:0030889[negative regulation of B cell proliferation] GO:0031647[regulation of protein stability] GO:0031648[protein destabilization] GO:0032991[protein-containing complex] GO:0033088[negative regulation of immature T cell proliferation in thymus] GO:0033235[positive regulation of protein sumoylation] GO:0043065[positive regulation of apoptotic process] GO:0043517[positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046825[regulation of protein export from nucleus] GO:0048103[somatic stem cell division] GO:0050821[protein stabilization] GO:0051444[negative regulation of ubiquitin-protein transferase activity] GO:0051726[regulation of cell cycle] GO:0055105[ubiquitin-protein transferase inhibitor activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070534[protein K63-linked ubiquitination] GO:0090398[cellular senescence] GO:0097371[MDM2/MDM4 family protein binding] GO:0097718[disordered domain specific binding] GO:1900182[positive regulation of protein localization to nucleus] GO:1901798[positive regulation of signal transduction by p53 class mediator] GO:1902510[regulation of apoptotic DNA fragmentation] GO:1904667[negative regulation of ubiquitin protein ligase activity] GO:1990000[amyloid fibril formation] GO:1990948[ubiquitin ligase inhibitor activity] GO:2000059[negative regulation of ubiquitin-dependent protein catabolic process] GO:2000435[negative regulation of protein neddylation]
Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0001953[negative regulation of cell-matrix adhesion] GO:0003723[RNA binding] GO:0004861[cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0007049[cell cycle] GO:0007265[Ras protein signal transduction] GO:0008285[negative regulation of cell population proliferation] GO:0019901[protein kinase binding] GO:0030308[negative regulation of cell growth] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0034393[positive regulation of smooth muscle cell apoptotic process] GO:0035985[senescence-associated heterochromatin focus] GO:0042326[negative regulation of phosphorylation] GO:0045736[negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0051059[NF-kappaB binding] GO:0051726[regulation of cell cycle] GO:0090398[cellular senescence] GO:0090399[replicative senescence] GO:2000045[regulation of G1/S transition of mitotic cell cycle] GO:2000111[positive regulation of macrophage apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014)
Phobius predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of male genital organs Cancers of the urinary system Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000209[protein polyubiquitination] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0005829[cytosol] GO:0006364[rRNA processing] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007049[cell cycle] GO:0008285[negative regulation of cell population proliferation] GO:0008637[apoptotic mitochondrial changes] GO:0010389[regulation of G2/M transition of mitotic cell cycle] GO:0010628[positive regulation of gene expression] GO:0016604[nuclear body] GO:0016925[protein sumoylation] GO:0019789[SUMO transferase activity] GO:0030889[negative regulation of B cell proliferation] GO:0031647[regulation of protein stability] GO:0031648[protein destabilization] GO:0032991[protein-containing complex] GO:0033088[negative regulation of immature T cell proliferation in thymus] GO:0033235[positive regulation of protein sumoylation] GO:0043065[positive regulation of apoptotic process] GO:0043517[positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046825[regulation of protein export from nucleus] GO:0048103[somatic stem cell division] GO:0050821[protein stabilization] GO:0051444[negative regulation of ubiquitin-protein transferase activity] GO:0051726[regulation of cell cycle] GO:0055105[ubiquitin-protein transferase inhibitor activity] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070534[protein K63-linked ubiquitination] GO:0090398[cellular senescence] GO:0097371[MDM2/MDM4 family protein binding] GO:0097718[disordered domain specific binding] GO:1900182[positive regulation of protein localization to nucleus] GO:1901798[positive regulation of signal transduction by p53 class mediator] GO:1902510[regulation of apoptotic DNA fragmentation] GO:1904667[negative regulation of ubiquitin protein ligase activity] GO:1990000[amyloid fibril formation] GO:1990948[ubiquitin ligase inhibitor activity] GO:2000059[negative regulation of ubiquitin-dependent protein catabolic process] GO:2000435[negative regulation of protein neddylation]
The Human Protein Atlas project is funded
